Abstract: A pump used to infuse a fluid into a patient is controlled in accordance with an algorithm that enables a microprocessor to monitor and adjust each pump cycle to compensate for a differential pressure between the pump's inlet and outlet. The algorithm defines a fluid delivery protocol that is applied in controlling the operation of the pump to achieve a desired rate, volume, and timing of the fluid infusion. Fluid is delivered by the pump when a plunger compresses an elastomeric membrane overlying a fluid chamber. Due to the small volume of the chamber, an incremental change in the plunger position before the delivery stroke produces a significant change in the delivery pressure. At the beginning of a pump cycle, the microprocessor determines the differential pressure between the inlet and outlet of the pump, and adjusts the plunger position before the delivery stroke to compensate for the differential pressure.

Abstract: A pump used to infuse a fluid into a patient is controlled in accordance with an algorithm that enables a microprocessor to monitor and adjust each pump cycle to compensate for a differential pressure between the pump's inlet and outlet. The algorithm defines a fluid delivery protocol that is applied in controlling the operation of the pump to achieve a desired rate, volume, and timing of the fluid infusion. Fluid is delivered by the pump when a plunger compresses an elastomeric membrane overlying a fluid chamber. Due to the small volume of the chamber, an incremental change in the plunger position before the delivery stroke produces a significant change in the delivery pressure. At the beginning of a pump cycle, the microprocessor determines the differential pressure between the inlet and outlet of the pump, and adjusts the plunger position before the delivery stroke to compensate for the differential pressure.

Abstract: Devices for delivering an aerosolized drug formulation and methods for using such devices are herein provided. Specifically, the invention relates to a drug delivery device that contains a drug formulation and an actuator for aerosolizing the formulation in preparation for drug delivery. The drug delivery devices of the invention are configured for delivering a single dose of an active agent (e.g., a pharmaceutical compound) or a mixture of multiple active agents and may further be configured so as to be hand-held, self-contained, portable and disposable. Methods of treatment and drugs that are suitable for use in the subject devices are also disclosed.

Abstract: A pump used to infuse a fluid into a patient is controlled in accordance with an algorithm that enables a microprocessor to monitor and adjust each pump cycle to compensate for a differential pressure between the pump's inlet and outlet. The algorithm defines a fluid delivery protocol that is applied in controlling the operation of the pump to achieve a desired rate, volume, and timing of the fluid infusion. Fluid is delivered by the pump when a plunger compresses an elastomeric membrane overlying a fluid chamber. Due to the small volume of the chamber, an incremental change in the plunger position before the delivery stroke produces a significant change in the delivery pressure. At the beginning of a pump cycle, the microprocessor determines the differential pressure between the inlet and outlet of the pump, and adjusts the plunger position before the delivery stroke to compensate for the differential pressure.

Abstract: A pump used to infuse a fluid into a patient is controlled in accordance with an algorithm that enables a microprocessor to monitor and adjust each pump cycle to compensate for a differential pressure between the pump's inlet and outlet. The algorithm defines a fluid delivery protocol that is applied in controlling the operation of the pump to achieve a desired rate, volume, and timing of the fluid infusion. Fluid is delivered by the pump when a plunger compresses an elastomeric membrane overlying a fluid chamber. Due to the small volume of the chamber, an incremental change in the plunger position before the delivery stroke produces a significant change in the delivery pressure. At the beginning of a pump cycle, the microprocessor determines the differential pressure between the inlet and outlet of the pump, and adjusts the plunger position before the delivery stroke to compensate for the differential pressure.

Abstract: A pump used to infuse a fluid into a patient is controlled in accordance with an algorithm that enables a microprocessor to monitor and adjust each pump cycle to compensate for a differential pressure between the pump's inlet and outlet. The algorithm defines a fluid delivery protocol that is applied in controlling the operation of the pump to achieve a desired rate, volume, and timing of the fluid infusion. Fluid is delivered by the pump when a plunger compresses an elastomeric membrane overlying a fluid chamber. Due to the small volume of the chamber, an incremental change in the plunger position before the delivery stroke produces a significant change in the delivery pressure. At the beginning of a pump cycle, the microprocessor determines the differential pressure between the inlet and outlet of the pump, and adjusts the plunger position before the delivery stroke to compensate for the differential pressure.

Abstract: An environmentally safe lubricating composition comprising a suspension of submicron molybdenum disulfide in canola oil is disclosed. Preferably the canola oil comprises trimethylol propane trioleate ester. In combining the molybdenum disulfide with the canola oil it preferred that the high shear mixing occur in the presence of a magnetic field.

Abstract: An environmentally safe lubricating composition comprising a suspension of submicron molybdenum disulfide in canola oil is disclosed. Preferably the canola oil comprises trimethylol propane trioleate ester. In combining the molybdenum disulfide with the canola oil it preferred that the high shear mixing occur in the presence of a magnetic field.

Abstract: A pump used to infuse a fluid into a patient is controlled in accordance with an algorithm that enables a microprocessor to monitor and adjust each pump cycle to compensate for a differential pressure between the pump's inlet and outlet. The algorithm defines a fluid delivery protocol that is applied in controlling the operation of the pump to achieve a desired rate, volume, and timing of the fluid infusion. Fluid is delivered by the pump when a plunger compresses an elastomeric membrane overlying a fluid chamber. Due to the small volume of the chamber, an incremental change in the plunger position before the delivery stroke produces a significant change in the delivery pressure. At the beginning of a pump cycle, the microprocessor determines the differential pressure between the inlet and outlet of the pump, and adjusts the plunger position before the delivery stroke to compensate for the differential pressure.

Abstract: A pump used to infuse a fluid into a patient is controlled in accordance with an algorithm that enables a microprocessor to monitor and adjust each pump cycle to compensate for a differential pressure between the pump's inlet and outlet. The algorithm defines a fluid delivery protocol that is applied in controlling the operation of the pump to achieve a desired rate, volume, and timing of the fluid infusion. Fluid is delivered by the pump when a plunger compresses an elastomeric membrane overlying a fluid chamber. Due to the small volume of the chamber, an incremental change in the plunger position before the delivery stroke produces a significant change in the delivery pressure. At the beginning of a pump cycle, the microprocessor determines the differential pressure between the inlet and outlet of the pump, and adjusts the plunger position before the delivery stroke to compensate for the differential pressure.

Abstract: A coupler for connecting a drive shaft to a driven member and accommodating a substantial misalignment between the drive shaft and the driven member, while minimizing audible noise and vibration. The coupling includes a hollow core nest element having a plurality of slots formed in one end, two substantially identical elongate body elements, and a plurality of spring elements. Each elongate body element has two ends, a first end being adapted to couple with either the drive shaft or the driven member, and a second end that includes a plurality of posts that engage the slots of the hollow core nest.

Abstract: A method and apparatus for driving a stepper motor such that when the motor is stepped, the velocity of the motor is substantially zero upon reaching a new stepped position, thereby eliminating overshoot and ringing, and the wasted energy associated with these effects. The method comprises energizing at least one of the stepper motor windings at a predetermined current level for a predetermined step time, wherein the current level is determined as a function of the step time and dynamic single-step response characteristics of the stepper motor and load so that the motor velocity is substantially zero when the adjacent stepped position is reached. At this point, the stepper motor windings that were energized to make the rotor of the motor move are de-energized, whereupon the rotor is held in place by the inherent detent torque of the stepper motor. Since the velocity of the motor is substantially zero when the adjacent stepped position is achieved, there is no overshoot, and thus ringing is eliminated.

Abstract: An IV pump actuates a disposable cassette having two parallel fluid paths that include first and second pumping chambers. The disposable cassette (12) has a housing(14) that includes a back portion (152) in which is defined a fluid path (60) between an inlet port (16) and an outlet port (18). An elastomeric membrane (150) is sealed between the back portion and a front portion (52). The elastomeric membrane is exposed through the front portion at a first pumping chamber (82), a second pumping chamber (84), inlet valves (70, 76), and outlet valves (86, 92). The inlet valves operate in a fully open mode, a fully closed mode, and a cracking mode. The cracking mode of the inlet valve occurs as the elastomeric membrane is initially forced further into the pumping chamber. If the pressure of the fluid in the pumping chamber exceeds a predetermined cracking pressure, the inlet valve is forced open so that the fluid flows from the pumping chamber back toward the inlet port.

Abstract: A system and method for mounting a piezoelectric crystal and forming electrical connections to it in an air bubble sensor (10). Piezoelectric crystals (26, 54) are mounted against inner surfaces of two opposed cavities (16, 44) using a conductive epoxy. The conductive epoxy both adhesively secures the crystals in place and provides conductive paths to adjacent conductive pins (28, 30, 46, and 48). To mount one of the piezoelectric crystals, a drop of the conductive epoxy is placed on an inner planar surface of the cavity and the crystal is pushed into the conductive epoxy, forcing the conductive epoxy to flow from under the crystal and into contact with one of the conductive pins. The inner end of another conductive pin is bent over the crystal and a drop of the conductive epoxy is then placed on the outwardly facing surface of the piezoelectric crystal, electrically and mechanically coupling the end of the conductive pin that was bent over, to the outwardly facing surface of the crystal.

Abstract: A pressure sensor (10) that responds to stress introduced into a pair of cantilevered beams (42, 44), to sense pressures at two measurement points in a cassette (80). The pressure sensor includes a base (12) on which the cantilevered beams are mounted. The base also supports two S-shaped flat springs (34, 36) mounted in spaced-apart, parallel array. Pins (28, 29) supported by the S-shaped flat springs each contact a free end of a different one of the cantilevered beams. The pins transfer a force from an elastomeric membrane (86). This force is developed by fluid pressure acting on the elastomeric membrane in a fluid passage of a cassette used for pumping fluid. The pins transmit the force to the free ends of the cantilevered beams as an applied stress. Strain gauges (58, 60) that are fixed to the cantilevered beams each respond by producing a signal indicative of fluid pressure.

Abstract: A identification system for a cassette pump wherein a plurality of different types of cassettes administer different types of drugs, and each type of cassette is characterized by a different type determinative indicia carried by the cassette, and the cassette pump includes a prime mover for actuating the plurality of different types of cassettes corresponding number of different operating modes, each operating mode being used with a corresponding different type of cassette, wherein the pump-cassette interface for receiving and actuating each of the different types of cassettes includes a sensor disposed at the pump-cassette interface, and when the sensor is engaged by the type determinative indicia of a cassette, the pump is able to identify the particular type cassette inserted into the pump, and initiate the operating mode of the pump associated with the specific type of cassette positioned at the pump-cassette interface.