Abstract: The invention relates to triazines and the use thereof to inhibit lysophosphatidic acid acyltransferase ? (LPAAT-?) activity. The invention further relates to methods of treating cancer using said triazines. The invention also relates to methods for screening for LPAAT-? activity.

Abstract: The invention relates to a method for computer-aided simulation of technical processes. Methods of this type are required in particular in evolution simulation models of technical, in particular physical and/or chemical processes, which are intended to be propagated in time (evolution).

Abstract: The invention relates to pyrimidines and uses thereof, including to inhibit lysophosphatidic acid acyltransferase ? (LPAAT-?) activity and/or proliferation of cells such as tumor-cells.

Abstract: The invention relates to a method for producing biperiden by reacting exo-1-(bi-cyclo[2.2.1]hept-5-en-2-yl)-3-piperidino-1-propanone with a phenylmagnesium compound. According to the invention, exo-1-(bi-cyclo[2.2.1]hept-5-en-2-yl)-3-piperidino-1-propanone can be obtained by reacting the exo-ether of enol silylene of formula (IV) with a compound of N-methylenepiperidinium.

Abstract: A tonneau cover is arranged to mount on the truck box of a conventional pick up truck for enclosing the box. The cover comprises a pair of panels which are pivotally mounted on respective sides of the box. The panels extend laterally inward such that free ends of the panels engage each other in a closed position. The panels may be pivoted upward and secured in an upward orientation by a pair of rails connected between the free ends of the respective panels in an extended position of the panels. The panels form a pair of side walls in the extended position for supporting large cargo in the box. The rails form a rack in the extended position for supporting additional cargo thereon. A locking device secures the panels in the closed position while a plurality of struts provides additional support to the panels when pivoting the panels between the closed and extended positions.

Abstract: Electrical power strips and electrical power strip assemblies are disclosed. An electrical power strip assembly includes electrical outlets for receiving power cord plugs. Strap mounts are provided, wherein each strap mount includes a connection point associated with one of the electrical outlets. A housing supports the electrical outlets in a connection plane and supports the plurality of strap mounts. Each strap mount connection point is proximal to the connection plane and to the electrical outlet associated with that strap mount connection point. Straps are coupled to the strap mounts. Each strap is configured to releasably secure a power cord plug received by one of the electrical outlets to the associated strap mount at the connection point.

Abstract: The invention relates to a device for controlling an exhaust gas stream. Said device comprises a housing (1, 101) with at least a first, second and third connection (2, 3, 4, 102, 103, 104) that form links to a first, second and third exhaust gas conduit for conducting the exhaust gases of an internal combustion engine, a first sliding element (6, 106) with a displaceable first sliding rod (6a, 106a) and a first sealing member (6c, 106c) that is located on said rod, a second sliding element (7, 107) with a displaceable second sliding rod (7, 107a) and a second sealing member (7c, 107c) that is located on said rod and an actuator for a force-assisted actuation of the device. According to the invention, a link (4c, 104b) can be established between the first and the second connection and can be adjusted by means of the first sealing member (6, 106) and a link (3c, 103b) can be established and adjusted between the first and the third connection by means of the second sealing member (7c, 107c).

Abstract: The invention relates to pyrimidines and uses thereof, including to inhibit lysophosphatidic acid acyltransferase ? (LPAAT-?) activity and/or proliferation of cells such as tumor-cells.

Abstract: A tonneau cover is arranged to mount on the truck box of a conventional pick up truck for enclosing the box. The cover comprises a pair of panels which are pivotally mounted on respective sides of the box. The panels extend laterally inward such that free ends of the panels engage each other in a closed position. The panels may be pivoted upward and secured in an upward orientation by a pair of rails connected between the free ends of the respective panels in an extended position of the panels. The panels form a pair of side walls in the extended position for supporting large cargo in the box. The rails form a rack in the extended position for supporting additional cargo thereon. A locking device secures the panels in the closed position while a plurality of struts provides additional support to the panels when pivoting the panels between the closed and extended positions.

Abstract: A probe for a system for determining the chemical signature of a pharmaceutical compound. The probe comprises: a housing; an inlet in the housing adapted to be connected to a transmitting optical fiber; a scanning aperture in the housing; a receiving outlet in the housing adapted to be connected to a receiving optical fiber; at least one transmission reflector positioned in the housing to receive laser light from the transmitting optical fiber and reflect the laser light through the detection outlet to a pharmaceutical vial containing a pharmaceutical compound positioned outside the housing, and at least one receiving reflector positioned in the housing to receive light reflected by the pharmaceutical compound and reflect the light to the receiving outlet. This configuration can enable rapid and accurate scanning of a pharmaceutical contained in a vial positioned adjacent the detection outlet.

Abstract: The invention provides new processes for preparing polyglutamic acid-therapeutic agent conjugates for clinical development and pharmaceutical use, and polyglutamic acid-therapeutic agent conjugates prepared by these processes.

Abstract: The invention relates to aryl triazines and uses thereof, including to inhibit lysophosphatidic acid acyltransferase ? (LPAAT-?) activity and/or proliferation of cells such as tumor cells.

Abstract: A tonneau cover is arranged to mount on the truck box of a conventional pick up truck for enclosing the box. The cover comprises a pair of panels which are pivotally mounted on respective sides of the box. The panels extend laterally inward such that free ends of the panels engage each other in a closed position. The panels may be pivoted upward and secured in an upward orientation by a pair of rails connected between the free ends of the respective panels in an extended position of the panels. The panels form a pair of side walls in the extended position for supporting large cargo in the box. The rails form a rack in the extended position for supporting additional cargo thereon. A locking device secures the panels in the closed position while a plurality of struts provides additional support to the panels when pivoting the panels between the closed and extended positions.

Abstract: Novel tricyclic compounds are disclosed having the general structure of Formulas I or II: were R1, R2 and R3 are defined in the written description of the invention. The compounds are useful for the treatment or prevention of symptoms or manifestations associated with diseases or disorders affected by intracellular cytokine signaling.

Abstract: The present invention relates to the use of water-redispersible dispersion powders based on one or more copolymers which are stabilized with at least one protective colloid in the production of composite thermal insulation systems, wherein the copolymer or copolymers contain(s) monomers containing carbonyl groups.

Abstract: The invention relates to pyridines and uses thereof, including to inhibit lysophosphatidic acid acyltransferase ? (LPAAT-?) activity and/or proliferation of cells such as tumor cells.

Abstract: The invention relates to triazines and the use thereof to inhibit lysophosphatidic acid acyltransferase ? (LPAAT-?) activity. The invention further relates to methods of treating cancer using said triazines. The invention also relates to methods for screening for LPAAT-? activity.

Abstract: Piston-cylinder unit including a working cylinder; a piston attached to a piston rod and installed with freedom of axial displacement in the working cylinder; and fastening elements, at least one of which is screwed into a threaded bore in the piston rod, where the interior pressure in the working cylinder holds a valve in the bore of the piston rod against an end surface of the fastening element. A vent groove leading to the atmosphere is provided between the end surface and the valve to create a pressure gradient to the working space, the groove being provided between the inner surface of the piston rod and the fastening element.

Abstract: The invention provides polyglutamic acid-therapeutic agent conjugates and methods for their preparation and use.

Abstract: A cleaning card for use in cleaning internal surfaces of machine components, including internal, rotatable idler rolls, includes a substrate having a central plane between opposed surfaces thereof, a machine direction dimension defined between opposed end edges and a transverse direction dimension defined between opposed side edges. The substrate includes an angled embossment forming angled, substantially non-collapsible, elongate raised ridges on opposite sides of the cleaning card substrate, with the raised ridges being oriented at an angle to the machine direction for incrementally engaging an idler roll surface along its axial extent as the raised ridges pass through a nip including the idler roll to aid in both rotating and cleaning one or more idler rolls. In preferred embodiments the opposed surfaces of the substrate each have a plurality of discrete, raised and collapsible working areas for engaging and cleaning internal surfaces of machine components in addition to idler rolls.