Abstract: The subject invention provides novel compositions of biologically active macrolide compounds which can advantageously be used in blocking cellular proliferation, treatment of cancer, treatment of fungal infections and control of spoilage of food, cosmetic and other consumer items.

Abstract: An internal support system for a hollow plastic post comprising a rigid column on to which the post can be sleeved, a member secured to the lower end of the column for securing same upright, and at least one support bracket attachable to the column at a selected point and configured to be received into the lower end of the post to provide internal support for a post sleeved on the column and over the bracket.

Abstract: Methods are disclosed for increasing the performance of a foil (100) by using tip droop (102) having an inward directed camber capable of generating an inward directed lifting force on the tip droop (102) in order to control spanwise flow conditions adjacent the tip (112) of a foil (100). Methods for varying the inward lifting shape of a tip droop (102) are provided along with methods for varying the angle of attack and camber of the tip droop (102) as the angle of attack of the foil (100) is changed and as spanwise flow conditions vary.

Abstract: An improved adjustable heel strap having an adjustable instep strap connected to the heel strap adjacent the heel portion of a swimmer' foot. Methods are provided for providing a highly adjustable strap system for preventing loss of swim fins in rough water conditions such as large surf and large open ocean waves. Methods are also provided for providing multi-dimensional heel strap adjustability around the ankle and instep to reduce ankle strain, increase ankle support, distribute load and stress points, reduce chaffing and blisters, increase leverage and power to the swim fin, reduce looseness and play between the foot and the swim fin, to increase comfort, to increase control, to improve positioning control, to improve sizing adjustment and to provide increased conformity to greater variations in foot and ankle sizes, shapes and contours.

Abstract: Methods are disclosed to design resilient hydrofoils (164) which are capable of having substantially similar large scale blade deflections under significantly varying loads. The methods permit the hydrofoil (164) to experience significantly large-scale deflections to a significantly reduced angle of attack under a relatively light load while avoiding excessive degrees of deflection under increased loading conditions. A predetermined compression range on the lee portion of said hydrofoil (164) permits the hydrofoil (164) to deflect to a predetermined reduced angle of attack with significantly low bending resistance.

Abstract: Designs and methods are disclosed for permitting permit scooped shaped swim fin blades (184) to flex around a transverse axis to a significantly reduced angle of attack while reducing or preventing the scooped blade portion (254) from collapsing or buckling under the longitudinal compression forces (222) exerted on the scooped portion during a large scale blade deflection (212) by strategically alleviating or controlling such compression forces (222). Method are also disclosed for increasing flow capacity, effective scoop length, scoop depth over a greater length of the blade, reducing blade resistance to large scale deflections, reducing bending resistance within scooped blade portions (254) that are experiencing high levels of blade deflection. Methods are also provided for reducing lost motion and increasing propulsion during the inversion phase of a reciprocating kicking stroke cycle while also increasing the formation of a scooped blade region (254) during the inversion phase of the stroke cycle.

Abstract: The subject invention provides novel compositions of biologically active macrolide compounds which can advantageously be used in blocking cellular proliferation, treatment of cancer, treatment of fungal infections and control of spoilage of food, cosmetic and other consumer items.

Abstract: Methods are disclosed to design resilient hydrofoils (164) which are capable of having substantially similar large scale blade deflections under significantly varying loads. The methods permit the hydrofoil (164) to experience significantly large-scale deflections to a significantly reduced angle of attack under a relatively light load while avoiding excessive degrees of deflection under increased loading conditions. A predetermined compression range on the lee portion of said hydrofoil (164) permits the hydrofoil (164) to deflect to a predetermined reduced angle of attack with significantly low bending resistance. This predetermined compression range is significantly used up during the deflection to the predetermined angle of attack in an amount effective to create a sufficiently large leeward shift in the neutral bending surface with the load bearing portions of the hydrofoil (164) to permit the hydrofoil.

Abstract: An internal support system for a hollow plastic post comprising a rigid column on to which the post can be sleeved, a member secured to the lower end of the column for securing same upright, and at least one support bracket attachable to the column at a selected point and configured to be received into the lower end of the post to provide internal support for a post sleeved on the column and over the bracket.

Abstract: A storage box comprises a rectangular bottom, a rear wall, a front wall, a first end wall closing one end of said box, a second end wall hinged to one of the front and rear walls for opening and closing the other end of the box and a cover hinged to the rear wall for opening and closing the box at the top, the box being dimensioned to permit a lawnmower or the like to be run into said box through the end with the hinged end wall swung open and then stored within the box with the hinged end and the cover closed.

Abstract: A fence section comprising at least two elongated parallel hollow plastic fence rails having a series of registering apertures in opposing walls thereof to provide a series of picket receiving, passages therethrough spaced along and perpendicular to their length. A plurality of plastic pickets are inserted through the rail passages with the pickets in line along the length of the rails. Each picket has a passageway therethrough located within the rails. An elongated metal reinforcing and locking member is located within and slidable longitudinally of the rails to project through the aligned picket passageways to lock the pickets from removal from the rails while reinforcing the rails.

Abstract: The invention relates to certain steroidal glycoside derivatives useful as hypocholesterolemic agents and anti-atherosclerosis agents. The present invention is also directed to pharmaceutical compositions comprising such derivatives and use of such derivatives in treating hypercholesterolemia or atherosclerosis.

Abstract: Compounds of the formula ##STR1## the pharmaceutically acceptable salts thereof, wherein Q and R.sup.1 are as defined below, and novel carboxylic acid and acid halide intermediates used in the synthesis of such compounds. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents.

Abstract: The application discloses steroidal glycoside compounds, especially spirostanyl glycosides, which have a glycosyl group O-linked to the C-3 hydroxy radical of the steroid and where the moieties at the C-10 and C-11 positions of the steroid are the same or different and are selected from the group consisiting of methylene, hydroxy and carbonyl. These steroid glycosides are useful as hypocholesterolemic agents and anti-atherosclerosis agents.

Abstract: Compounds of the formula ##STR1## wherein R.sup.21 and R.sup.22 are as defined in the specification which are intermediates useful in the preparation of compounds of the formula ##STR2## and the pharmaceutically acceptable salts thereof, wherein Q and R.sup.1 are as defined in the specification. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents.

Abstract: Variously substituted 3,5-dihydroxy-6,8-nonadienoic acids and esters, are blood cholesterol lowering agents and so are useful in the prevention and treatment of cardiovascular diseases such as atherosclerosis.

Abstract: Variously substituted 4-(biphen-2-ylmethylcarbamoyl)-3-hydroxybutyric acids and esters, also named as N-(biphen-2-yl)-3-hydroxyglutaramic acid derivatives, are blood cholesterol lowering agents and so are useful in the prevention and treatment of cardiovascular diseases such as atherosclerosis.

Abstract: Variously substituted 3,5-dihydroxy-6,8-nonadienoic acids and esters, are blood cholesterol lowering agents and so are useful in the prevention and treatment of cardiovascular diseases such as atherosclerosis.

Abstract: A process for the synthesis of alpha,alpha-difluoroketones from alpha,alpha-difluoroacylsilanes and intermediates therefor.

Abstract: 2-Guanidino-4-arylthiazole compounds of the formula ##STR1## a pharmaceutically acceptable cationic or acid addition salt thereof whereinR.sup.1 is hydrogen, (C.sub.1 -C.sub.10)alkyl, optionally substituted phenyl or certain optionally substituted aralkyl groups;R.sup.2 is hydrogen or (C.sub.1 -C.sub.4)alkyl, andAr is certain optionally substituted pyrrolyl or indolyl groups; method for their use in treatment of gastric ulcers, by inhibition of parietal cell H.sup.+ /K.sup.+ ATPase, and antiinflammatory conditions in combination with piroxicam, for use in mammals, and pharmaceutical compositions containing said compounds.