Abstract: An auscultation device having a headset, a chest piece, and tubing connecting the chest piece to the headset. At least one connector disposed in the tubing between the headset and the chest piece and the at least one connector comprising a first female connector portion and a second male connector portion. The first female connector portion having a receiving cavity and a collar which is slidable and used to lock the first and second portions together, and the second male connector portion having a through hole, a compressible O-ring, and a latching ring collar.

Abstract: An auscultation device having a chest piece with a sound output aperture in fluid communication with a diaphragm on a bottom surface of the chest piece. A digital stethoscope component with a sound input aperture and a connector fluidly connecting the sound output aperture to the sound input aperture. The connector is designed such that the auscultation device is free standing on a horizontal surface.

Abstract: Methods and reagents for multiplex detection of antibodies are disclosed. In particular, the invention relates to multiplex detection of antibodies using antigen-DNA and antibody-binding agent-DNA conjugates carrying DNA barcodes for identifying and quantitating disease-relevant antibody isotypes, such as those involved in allergic responses, autoimmune diseases, infections, and inflammation.

Abstract: Methods and reagents for multiplex detection of antibodies are disclosed. In particular, the invention relates to multiplex detection of antibodies using antigen-DNA and antibody-binding agent-DNA conjugates carrying DNA barcodes for identifying and quantitating disease-relevant antibody isotypes, such as those involved in allergic responses, autoimmune diseases, infections, and inflammation.

Abstract: Apparatus for manufacturing mailpieces, comprising a supply module for supplying cold seal paper to form an envelope body, a feeding module for collating documents to form the content to be inserted in the mailpiece, and a pair of finishing rollers for folding the envelope body around the content and sealing the mailpiece in a single finishing step.

Abstract: Some embodiments of the systems and methods provided herein relate to an assay. Some such embodiments include multiplex affinity probes and an antigen probe. multiplex affinity probes and an antigen probe Some embodiments include contacting a biological sample with the probes, wherein target binding agents such as antibodies in the biological sample compete away the multiplex affinity probes from binding to the antigen probe. Some such embodiments include detecting a decrease in binding of the multiplex affinity probes to the antigen probe, thereby indicating the presence or an amount of the target binding agents in the biological sample.

Abstract: A tissue processing apparatus for processing biological tissue. The tissue processing apparatus includes: an extraction device configured to, when connected to a reagent receptacle, take reagent out from the reagent receptacle for use by the tissue processing apparatus; a tag reader configured to read information from a machine-readable tag.

Abstract: A method includes assembling a sensor subassembly that includes a sensor, a sensor mount, a collar, a sharp, and a sensor cap. The method includes loading a sensor in a sensor mount; dispensing adhesive into a mount channel of the sensor mount; clamping a collar to the sensor mount; and curing the adhesive to fix the collar to the sensor mount. The method can also include inserting a sharp into the sensor mount over the sensor an attaching a sensor cap to the sensor and sensor sharp to provide a sealed sensor subassembly. Methods of assembling an on-body sensor puck assembly and an applicator assembly, and a sensor including a tail, a flag, and a neck that interconnects the tail and the flag and methods of configuring a sensor are also disclosed.

Abstract: Methods are provided for detecting antigen binding agents in samples. Aspects of the methods include detection of the aggregation of antigen binding agents with polynucleotide-bound antigens by sensitive proximity-based association of the anti-gen-bound polynucleotides. Aspects of the methods also include methods for the detection of such proximity-based association through nucleic acid amplification. In addition, compositions, e.g., reagents, kits, and devices, useful in practicing various embodiments of the methods are provided.

Abstract: Methods are provided for detecting antigen binding agents in samples. Aspects of the methods include detection of the aggregation of antigen binding agents with polynucleotide-bound antigens by sensitive proximity-based association of the antigen-bound polynucleotides. Aspects of the methods also include methods for the detection of such proximity-based association through nucleic acid amplification. In addition, compositions, e.g., reagents, kits, and devices, useful in practicing various embodiments of the methods are provided.

Abstract: Methods and reagents for blocking non-specific interactions with nucleic acids are disclosed. In particular, the invention relates to multi-valent blockers comprising multiple negatively charged polymers or materials attached to a common scaffold and their use in blocking non-specific interactions with nucleic acids.

Abstract: A method of rendering a plurality of objects to a display of a computing device comprises a rendering process which performs steps of: traversing a render tree which is indicative of a hierarchy of the plurality of objects; allocating a buffer in a graphics memory of the computing device; and generating an image scratchpad. The image scratchpad is generated by determining, for each object, an object size and object layout parameters; determining a render status of the object; and responsive to a determination that the render status indicates that image data of the object is in a form which can be directly written to the graphics memory, appending to the image scratchpad by writing the image data of the object to an unoccupied area of the buffer. Respective image or text objects are rendered to the display by retrieving image data from the image scratchpad 552 scratchpad, and drawing the retrieved image data based on respective object layout parameters.

Abstract: A method of simultaneously displaying a plurality of user interface pages on a display screen of a computing device includes generating a render tree comprising a plurality of objects each having one or more layout parameters, the plurality of objects including a plurality of page objects each having one or more child objects. A launcher application is first attached to a first container and then a list object is attached to the first container, the list object comprising a plurality of page containers to which the page objects are attached. The render tree is traversed to recursively attach the one or more child objects to respective page containers. In response to user input the list object is transformed to a grid object, the grid object comprising transformed page containers having transformed layout parameters, the transformed layout parameters being generated from layout parameters of the page objects in accordance with a grid layout.

Abstract: Methods and reagents for blocking non-specific interactions with nucleic acids are disclosed. In particular, the invention relates to multi-valent blockers comprising multiple negatively charged polymers or materials attached to a common scaffold and their use in blocking non-specific interactions with nucleic acids.

Abstract: Methods and reagents for blocking non-specific interactions with nucleic acids are disclosed. In particular, the invention relates to multi-valent blockers comprising multiple negatively charged polymers or materials attached to a common scaffold and their use in blocking non-specific interactions with nucleic acids.

Abstract: Methods and reagents for multiplex detection of antibodies are disclosed. In particular, the invention relates to multiplex detection of antibodies using antigen-DNA and antibody-binding agent-DNA conjugates carrying DNA barcodes for identifying and quantitating disease-relevant antibody isotypes, such as those involved in allergic responses, autoimmune diseases, infections, and inflammation.

Abstract: A tissue processing apparatus for processing biological tissue. The tissue processing apparatus includes: an extraction device configured to, when connected to a reagent receptacle, take reagent out from the reagent receptacle for use by the tissue processing apparatus; a tag reader configured to read information from a machine-readable tag.

Abstract: Provided is a laser system that includes a laser head having a laser holder configured to house a laser beam and a lens for reflecting the laser beam at a predetermined wavelength, and a thermal-mechanical adjustment device disposed on the laser head and configured to adjust a temperature and an alignment of the laser beam, to maintain the predetermined wavelength of the laser beam.

Abstract: An apparatus may have a first reflector and a second reflector positioned on either side of a sample volume for a gas sample. The configuration of the first reflector may be variable between at least first and second configurations, wherein each of the first and second configurations is arranged such that a beam of optical radiation from an optical beam origin is directed to a detector location via the sample volume. In the second configuration the beam of optical radiation is reflected at least once from each of the first and second reflectors and the path length of the beam of optical radiation through the sample volume is greater than in the first configuration.