Patents by Inventor Peter A. Smalley

Peter A. Smalley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DIFLUOROCYCLOHEXYL DERIVATIVES AS IL-17 MODULATORS
    Publication number: 20230271951
    Abstract: A series of substituted 4,4-difluorocyclohexyl derivatives as defined herein, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.
    Type: Application
    Filed: April 6, 2021
    Publication date: August 31, 2023
    Inventors: Prafulkumar Tulshibhai CHOVATIA, Anne Marie FOLEY, Gregory William HASLETT, Martin Clive HUTCHINGS, James Andrew JOHNSON, Fabien Claude LECOMTE, Nathaniel Julius Thomas MONCK, Joanna Rachel QUINCEY, Konstantinos RAMPALAKOS, James Thomas REUBERSON, Adam Peter SMALLEY, Giancarlo TRANI, Darshan Gunvant VAIDYA
  • Fused Imidazole Derivatives as IL-17 Modulators
    Publication number: 20220242855
    Abstract: A series of substituted fused bicyclic imidazole derivatives of formula (I), including benzimidazole derivatives and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments including inflammatory and autoimmune disorders, wherein i. a. A represents C—R1 or N; B represents C—R2 or N; D represents C—R3 or N; E represents C—R4 or N; Z represents —CH(R5)N(H)CH2R6, —CH(R5)N(H)S(O)2R6, —C(?CR5aR5b)N(H)C(O)R6, —CH(R5)R7, —CH(R5)N(H)R7 or —CH(R5)C(O)N(H)R7; R0 represents hydrogen or C1-6 alkyl.
    Type: Application
    Filed: June 24, 2020
    Publication date: August 4, 2022
    Inventors: Shuyu Chu, Helen Tracey Horsley, James Thomas Reuberson, Richard David Taylor, Zhaoning Zhu, Rose Elizabeth Chappell, Gregory William Haslett, Adam Peter Smalley, Nathaniel Julius Thomas Monck, Gareth Neil Brace, Prafulkumar Tulshibhai Chovatia
  • Spirocyclic indolines as IL-17 modulators
    Patent number: 11052076
    Abstract: A series of substituted spirocyclic 2-oxoindoline derivatives, and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.
    Type: Grant
    Filed: June 12, 2018
    Date of Patent: July 6, 2021
    Assignee: UCB Biopharma SRL
    Inventors: Gareth Neil Brace, Rose Elizabeth Chappell, Hervé Jean Claude Deboves, Anne Marie Foley, Gregory Foulkes, Elizabeth Pearl Jones, Fabien Claude Lecomte, Joanna Rachel Quincey, Monika-Sarah Elisabeth Dorothea Schulze, Matthew Duncan Selby, Adam Peter Smalley, Richard David Taylor, Robert James Townsend, Zhaoning Zhu
  • Pharmaceutical 6,5 Heterobicyclic Ring Derivatives
    Publication number: 20200399268
    Abstract: The invention relates to 6,5 heterobicyclic ring derivatives of formula (I), processes for preparing them, pharmaceutical compositions containing them and their use for the treatment of inflammatory conditions driven by STING activation, such as, but not confined to, SLE and geographic atrophy.
    Type: Application
    Filed: February 15, 2019
    Publication date: December 24, 2020
    Inventors: Jag Paul Heer, Michal Sarah Hallside, Adam Peter Smalley, Josep Llaveria Cros, Benedicte Lallemand, Martin Alexander Lowe, Xianfu Li, Anthony John Richardson, Robert James Townsend
  • Spirocyclic Indolines as IL-17 Modulators
    Publication number: 20200138797
    Abstract: A series of substituted spirocyclic 2-oxoindoline derivatives, and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.
    Type: Application
    Filed: June 12, 2018
    Publication date: May 7, 2020
    Inventors: Gareth Neil Brace, Rose Elizabeth Chappell, Hervé Jean Claude Deboves, Anne Marie Foley, Gregory Foulkes, Elizabeth Pearl Jones, Fabien Claude Lecomte, Joanna Rachel Quincey, Monika-Sarah Elisabeth Dorothea Schulze, Matthew Duncan Selby, Adam Peter Smalley, Richard David Taylor, Robert James Townsend, Zhaoning Zhu
  • FLUORINATED RESORUFIN COMPOUNDS AND THEIR APPLICATION
    Publication number: 20170037248
    Abstract: The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compound in one or more assay formats.
    Type: Application
    Filed: October 21, 2016
    Publication date: February 9, 2017
    Inventors: Robert Batchelor, Yue GE, Iain JOHNSON, Wai-Yee LEUNG, Jixiang LIU, Brian PATCH, Peter SMALLEY, Thomas STEINBERG, Kyle GEE
  • Fluorinated resorufin compounds and their application
    Patent number: 9212385
    Abstract: The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compound in one or more assay formats.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: December 15, 2015
    Assignee: Life Technologies Corporation
    Inventors: Robert H. Batchelor, Yue Ge, Iain Johnson, Wai-Yee Leung, Jixiang Liu, Brian Patch, Peter Smalley, Thomas Steinberg, Kyle Gee
  • BENEFICIATION OF FLY ASH
    Publication number: 20140306369
    Abstract: A method of beneficiating fly ash to produce particulate material for use as a filler/extender in plastics manufacturing. The method includes removal of extraneous surface deposits from surfaces of the particulate material.
    Type: Application
    Filed: October 19, 2012
    Publication date: October 16, 2014
    Inventors: Nigel Peter Smalley, Paul Anthony Shepheard, Philip Michael
  • FLUORINATED RESORUFIN COMPOUNDS AND THEIR APPLICATION
    Publication number: 20140220612
    Abstract: The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compound in one or more assay formats.
    Type: Application
    Filed: April 8, 2014
    Publication date: August 7, 2014
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Robert BATCHELOR, Yue GE, Iain JOHNSON, Wai-Yee LEUNG, Jixiang LIU, Brian PATCH, Peter SMALLEY, Thomas STEINBERG, Kyle GEE
  • FLUORINATED RESORUFIN COMPOUNDS AND THEIR APPLICATION
    Publication number: 20130102014
    Abstract: The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compound in one or more assay formats.
    Type: Application
    Filed: September 12, 2012
    Publication date: April 25, 2013
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Robert Harley Batchelor, Yue Ge, Iain D. Johnson, Wai-Yee Leung, Jixiang Liu, Brian Patch, Peter Smalley, Thomas Steinberg
  • IMMUNOSORBENT ASSAY SUPPORT AND METHOD OF USE
    Publication number: 20120107844
    Abstract: Embodiments of the present invention provide an immunosorbent assay support immobilized with an intermediate binding antibody and their method of use in an improved immunoassay format.
    Type: Application
    Filed: October 20, 2011
    Publication date: May 3, 2012
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Schuyler B. Corry, Yue Ge, Iain D. Johnson, Peter A. Smalley
  • FLUORINATED RESORUFIN COMPOUNDS AND THEIR APPLICATION
    Publication number: 20110086341
    Abstract: The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compound in one or more assay formats.
    Type: Application
    Filed: December 17, 2010
    Publication date: April 14, 2011
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Robert Batchelor, Yue Ge, Iain Johnson, Wai-Yee Leung, Jixiang Liu, Brian Patch, Peter Smalley, Thomas Steinberg, Kyle Gee
  • Fluorinated resorufin compounds and their application
    Patent number: 7875261
    Abstract: The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compound in one or more assay formats.
    Type: Grant
    Filed: January 16, 2008
    Date of Patent: January 25, 2011
    Assignee: Life Technologies Corporation
    Inventors: Robert Batchelor, Yue Ge, Iain Johnson, Wai-Yee Leung, Jixiang Liu, Brian Patch, Peter Smalley, Thomas Steinberg, Kyle Gee
  • IMMUNOSORBENT ASSAY SUPPORT AND METHOD OF USE
    Publication number: 20090298199
    Abstract: Embodiments of the present invention provide an immunosorbent assay support immobilized with an intermediate binding antibody and their method of use in an improved immunoassay format.
    Type: Application
    Filed: June 5, 2009
    Publication date: December 3, 2009
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Schuyler B. CORRY, Yue Ge, Iain D. JOHNSON, Peter A. Smalley
  • FLUORINATED RESORUFIN COMPOUNDS AND THEIR APPLICATION
    Publication number: 20080113341
    Abstract: The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compound in one or more assay formats.
    Type: Application
    Filed: January 16, 2008
    Publication date: May 15, 2008
    Applicant: INVITROGEN CORPORATION
    Inventors: Robert BATCHELOR, Yue GE, Iain JOHNSON, Wai-Yee LEUNG, Jixiang LIU, Brian PATCH, Peter SMALLEY, Thomas STEINBERG
  • IMMUNOSORBENT ASSAY SUPPORT AND METHOD OF USE
    Publication number: 20070161055
    Abstract: Embodiments of the present invention provide an immunosorbent assay support immobilized with an intermediate binding antibody and their method of use in an improved immunoassay format.
    Type: Application
    Filed: October 31, 2006
    Publication date: July 12, 2007
    Applicant: INVITROGEN CORPORATION
    Inventors: Schuyler CORRY, Yue GE, Iain JOHNSON, Peter SMALLEY
  • Fluorinated resorufin compounds and their application
    Publication number: 20050096315
    Abstract: The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compound in one or more assay formats.
    Type: Application
    Filed: November 1, 2004
    Publication date: May 5, 2005
    Inventors: Robert Batchelor, Yue Ge, Kyle Gee, Iain Johnson, Wai-Yee Leung, Jixiang Liu, Brian Patch, Peter Smalley, Thomas Steinberg