Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein.

Abstract: The present disclosure features compounds and related compositions that, inter alia, modulate nucleic acid splicing, e.g., splicing of a pre-mRNA, as well as methods of use thereof.

Abstract: Systems and methods for facilitating the provision of goods using automated stores are provided. The automated stores are distributed across a geographical area and are remotely controlled to create an on-line marketplace. Users of the system can access the marketplace using an interactive portal to purchase items. Buyers can create purchase orders for items stocked in the marketplace and collect the items at one or more automated stores. The items are consigned to the buyers in real time at the automated store.

Abstract: A school bus stop arm and drive unit therefor are disclosed. The stop arm includes a stop sign and a drive unit for moving the stop sign between a retracted position and a deployed position. In some embodiments the stop sign is illuminated. In some embodiments the drive unit includes a controller.

Abstract: The present disclosure features compounds and related compositions that, inter alia, modulate nucleic acid splicing, e.g., splicing of a pre-mRNA, as well as methods of use thereof.

Abstract: The present disclosure features compounds and related compositions that, inter alia, modulate nucleic acid splicing, e.g., splicing of a pre-mRNA, as well as methods of use thereof.

Abstract: Embodiments provided herein relate to methods and compositions for preparing nucleic acid libraries. Some embodiments include preparing libraries from nucleic acids obtained from degraded samples, such as ancient samples and fixed samples.

Abstract: Methods of treating of interstitial lung disease, reducing pulmonary function decline in a subject with interstitial lung disease (ILD), and increasing forced vital capacity (FVC) in a subject suffering from ILD are provided, wherein the methods include administration of treprostinil.

Abstract: A method and an intersection testing module in a ray tracing system for performing intersection testing for a ray with respect to a plurality of convex polygons, each of which is defined by an ordered set of vertices. The vertices of the convex polygons are projected onto a pair of axes orthogonal to the ray direction. For each edge of a convex polygon defined by two of the projected vertices, a signed parameter is determined, wherein the sign of the signed parameter is indicative of which side of the edge the ray passes on. If the ray is determined to intersect a point on the edge then the sign of the signed parameter is determined using a module which is configured to: take as inputs, indications which classify each of pi, qi, pj and qj coordinates as negative, zero or positive, and output, for valid combinations of classifications of the pi, qi, pj and qj coordinates, an indication of the sign of the signed parameter.

Abstract: A method and an intersection testing module in a ray tracing system for determining whether a ray intersects a three-dimensional axis-aligned box. It is determined whether a first condition is satisfied, wherein the first condition is, or is equivalent to, ? "\[LeftBracketingBar]" C x - C z ? D x D z ? "\[RightBracketingBar]" ? H z ? D x D z + H x . It is determined whether a second condition is satisfied, wherein the second condition is, or is equivalent to, ? "\[LeftBracketingBar]" C y - C z ? D y D z ? "\[RightBracketingBar]" ? H z ? D y D z + H y .

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: The present disclosure features compounds and related compositions that, inter alia, modulate nucleic acid splicing, e.g., splicing of a pre-mRNA, as well as methods of use thereof.

Abstract: The present disclosure features compounds (I) and related compositions that, inter alia, modulate nucleic acid splicing, e.g., splicing of a pre-mRNA, as well as methods of use thereof.

Abstract: The present disclosure features compounds and related compositions that, inter alia, modulate nucleic acid splicing, e.g., splicing of a pre-mRNA, as well as methods of use thereof.

Abstract: The present disclosure features compounds and related compositions that, inter alia, modulate nucleic acid splicing, e.g., splicing of a pre-mRNA, as well as methods of use thereof.

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: A probe may be inserted into a body cavity to perform diagnostic intervention(s), therapeutic intervention(s), or both. The probe may be inserted through a body aperture that is naturally occurring or man-made, intentionally or by accident. The body aperture may form a seal encircling the probe so that insufflation retention material may be effectively retained in the body cavity so that an operator can perform the intervention(s). However, there may be leakage of the insufflation material. The insufflation retention device is configured to form an effective seal contactingly adjacent the body aperture and to provide a passageway for the introduction of the probe into the body cavity, such that a diagnostic intervention or therapeutic intervention or both may be performed.

Abstract: Methods and decoding units for decoding a compressed data structure to determine a decoded value. The compressed data structure encodes a set of Haar coefficients for a block of pixels, including a plurality of differential coefficients and a sum coefficient. The compressed data structure includes a set of exponent bits representing exponents of the differential coefficients, a set of sign bits representing signs for the differential coefficients, a set of sum bits representing the sum coefficient. The compressed data structure is unpacked to identify the set of exponent bits, the set of sign bits and the set of sum bits. The identified set of exponent bits is used to determine exponents for the differential coefficients. The identified set of sign bits is used to determine signs the differential coefficients. The identified set of sum bits is used to determine the sum coefficient.