Abstract: The present disclosure relates to pirfenidone (5-methyl-1-phenyl-2-(1H)-pyridone) and its derivatives and pharmaceutically acceptable salts thereof, use of these compounds as a medicament, and for the manufacture of a medicament for treating or delaying the onset or development of pulmonary hypertension.

Abstract: The present invention relates to methods of diagnosing and/or prognosing proliferative disorders, especially brain cancers (e.g. gliomas). In particular, the present invention provides a means to conveniently detect malignant tumors merely by assaying or analyzing blood (particularly blood serum). Cytokines and/or angiogenesis factors in blood serum have been found to be surprisingly powerful at indicating the presence of brain cancers in a subject. Moreover, spectroscopic analysis, especially ATR-FTIR analysis, of a blood sample has been demonstrated to be surprisingly effective at producing a signature that can be correlated with the presence, extent, severity, or aggressiveness of malignant tumors in a subject.

Abstract: The invention relates to a [crane], particularly crawler crane or mobile crane, with at least one monitoring and simulation means, by means of which a state of the crane can be monitored and/or simulated, wherein the monitoring and simulation means comprise at least one input means and at least one output means, and wherein, by means of the monitoring and simulation means, the change in state, particularly the bearing load curve of the crane, and particularly also the movement of the crane and/or of the boom of the crane, can be represented at any time, and/or a possible state and/or a possible change in state of the crane, particularly the bearing load curve of the crane, can be simulated and/or represented.

Abstract: The present disclosure relates to a method for determining the admissible load capacity of a crane, in which the load capacity is determined in dependence on at least one first and one second parameter and which comprises a first step, in which the load capacity for the value of the first parameter with different values of the second parameter is determined by calculation or by interpolation or extrapolation on the basis of known values of the load capacity with specific values of the first parameter, and which comprises a second step, in which the determination of the load capacity for the second parameter is performed on the basis of the values of the load capacity determined in the first step for different values of the second parameter by calculation or by interpolation or extrapolation.

Abstract: The present disclosure relates to pirfenidone (5-methyl-1-phenyl-2-(1H)-pyridone) and its derivatives and pharmaceutically acceptable salts thereof, use of these compounds as a medicament, and for the manufacture of a medicament for treating or delaying the onset or development of pulmonary hypertension.

Abstract: The present invention relates to methods of diagnosing and/or prognosing proliferative disorders, especially brain cancers (e.g. gliomas). In particular, the present invention provides a means to conveniently detect malignant tumours merely by assaying or analysing blood (particularly blood serum). Cytokines and/or angiogenesis factors in blood serum have been found to be surprisingly powerful at indicating the presence of brain cancers in a subject. Moreover, spectroscopic analysis, especially ATR-FTIR analysis, of a blood sample has been demonstrated to be surprisingly effective at producing a signature that can be correlated with the presence, extent, severity, or aggressiveness of malignant tumours in a subject.

Abstract: The present invention relates to methods of diagnosing and/or prognosing proliferative disorders, especially brain cancers (e.g. gliomas). In particular, the present invention provides a means to conveniently detect malignant tumours merely by assaying or analysing blood (particularly blood serum). Cytokines and/or angiogenesis factors in blood serum have been found to be surprisingly powerful at indicating the presence of brain cancers in a subject. Moreover, spectroscopic analysis, especially ATR-FTIR analysis, of a blood sample has been demonstrated to be surprisingly effective at producing a signature that can be correlated with the presence, extent, severity, or aggressiveness of malignant tumours in a subject.

Abstract: The present invention relates to methods of diagnosing and/or prognosing proliferative disorders, especially brain cancers (e.g. gliomas). In particular, the present invention provides a means to conveniently detect malignant tumours merely by as saying or analysing blood (particularly blood serum). Cytokines and/or angiogenesis factors in blood serum have been found to be surprisingly powerful at indicating the presence of brain cancers in a subject. Moreover, spectroscopic analysis, especially ATR-FTIR analysis, of a blood sample has been demonstrated to be surprisingly effective at producing a signature that can be correlated with the presence, extent, severity, or aggressiveness of malignant tumours in a subject.

Abstract: The present invention relates to methods of diagnosing and/or prognosing proliferative disorders, especially brain cancers (e.g. gliomas). In particular, the present invention provides a means to conveniently detect malignant tumours merely by assaying or analysing blood (particularly blood serum). Cytokines and/or angiogenesis factors in blood serum have been found to be surprisingly powerful at indicating the presence of brain cancers in a subject. Moreover, spectroscopic analysis, especially ATR-FTIR analysis, of a blood sample has been demonstrated to be surprisingly effective at producing a signature that can be correlated with the presence, extent, severity, or aggressiveness of malignant tumours in a subject.

Abstract: The present disclosure relates to a method for determining the admissible load capacity of a crane, in which the load capacity is determined in dependence on at least one first and one second parameter and which comprises a first step, in which the load capacity for the value of the first parameter with different values of the second parameter is determined by calculation or by interpolation or extrapolation on the basis of known values of the load capacity with specific values of the first parameter, and which comprises a second step, in which the determination of the load capacity for the second parameter is performed on the basis of the values of the load capacity determined in the first step for different values of the second parameter by calculation or by interpolation or extrapolation.

Abstract: A crane control system with a display and entry unit for showing and entering the crane operating mode information that is required for the load moment limiting and/or the crane control, especially corresponding to its current mechanical layout, wherein the crane control system comprises a logic that determines application and/or outfitting related dependencies between two or more input parameters.

Abstract: A thin film manufacturing apparatus is disclosed, including a liquid ejecting unit which ejects a liquid onto an object on which a film is to be formed and which forms a coating film; a first laser irradiating unit which continuously irradiates a laser light onto the coating film and which evaporates a solvent of the coating film; and a second laser irradiating unit which irradiates a laser light pulse onto the coating film of which the solvent is evaporated and which crystallizes the coating film of which the solvent is evaporated.

Abstract: A crane control system with a display and entry unit for showing and entering the crane operating mode information that is required for the load moment limiting and/or the crane control, especially corresponding to its current mechanical layout, wherein the crane control system comprises a logic that determines application and/or outfitting related dependencies between two or more input parameters.

Abstract: The present invention relates to a method for measuring phase boundaries of a material during the machining of a workpiece (12) with a machining beam, more preferably with a laser beam, and a device that is embodied in such a way as to carry out the method. According to said method, during the machining, a machining region (13) containing the impact point of the machining beam (1) on the workpiece (12) is illuminated at least approximately coaxially to the machining beam (1) by means of additional optical radiation (2). Radiation (3) reflected by the machining region (13) is detected, parallel to an incidence direction of the optical radiation (2) or at small angle thereto, by means of an optical detector with local resolution, in order to obtain an optical reflection pattern of the machining region (13).

Abstract: The invention relates to a [crane], particularly crawler crane or mobile crane, with at least one monitoring and simulation means, by means of which a state of the crane can be monitored and/or simulated, wherein the monitoring and simulation means comprise at least one input means and at least one output means, and wherein, by means of the monitoring and simulation means, the change in state, particularly the bearing load curve of the crane, and particularly also the movement of the crane and/or of the boom of the crane, can be represented at any time, and/or a possible state and/or a possible change in state of the crane, particularly the bearing load curve of the crane, can be simulated and/or represented.

Abstract: A mobile crane has at least one memory unit in which limit curves or limit values are stored for various crane parameters and which should not be exceeded, or only exceeded by issuing an alarm signal, to ensure safe operation of the crane. Crane safety is ensured by monitoring the individual limit values of the various parameters and checking the current position of the extendable and retractable props which serve to support the mobile crane. Depending upon the actual position the supporting cylinders reach, the tilting edge of the mobile crane is determined as a limit value. Furthermore, depending on the individual parameters of the mobile crane and the suspended load, whether the operating condition of the mobile crane lies within this limit value is determined.

Abstract: A one- or two-dimensional arrangement of flow cells is provided, as part of an array of sample compartments, with at least one inlet and outlet for each sample compartment, formed by a base plate and a body, with an arrangement of spatial recesses corresponding to the (geometrical) arrangement of the sample compartments, combined with the base plate. The arrangement allows for supplying to or removing from the sample compartments, which can be arranged at a high quantity on a small base area, even very small amounts of samples or reagents.

Abstract: The invention relates to measuring the concentration of analytes with the aid of an oxidase in an immersion sensor situated in a fluid or in a matrix containing fluid. Oxygen diffuses into the enzyme layer from within, from a gas-filled space connected to the atmosphere and/or to an oxygen reservoir. This enables oxygen saturation of the oxidase in a low-oxygen or oxygen-free medium and/or at high analyte concentrations. The analyte diffuses into the enzyme layer in a channel or a number of channels which contain(s) water and limit(s) diffusion, wherein the channel/channels on the surface of the sensor is/are filled with a protein-impermeable, hydrophilic matrix. By increasing the channel cross-section on the surface of the sensor and/or by connecting the channel/channels to a protein-impermeable, porous, hydrophilic layer on the surface of the sensor, the effect of outer deposits on the diffusion resistance of the analyte is reduced.

Abstract: A device includes a planar optical waveguide, as part of a sensor platform, and, connected to the platform directly or by means of a sealing medium, a sealing layer. The sealing layer forms either directly or by means of a sealing medium a tightly sealing layer. The sealing layer includes a multitude of recesses at least open towards the sensor platform, which form a corresponding multitude of sample compartments in a 2-dimensional arrangement.

Abstract: The present disclosure relates to a method for determining the admissible load capacity of a crane, in which the load capacity is determined in dependence on at least one first and one second parameter and which comprises a first step, in which the load capacity for the value of the first parameter with different values of the second parameter is determined by calculation or by interpolation or extrapolation on the basis of known values of the load capacity with specific values of the first parameter, and which comprises a second step, in which the determination of the load capacity for the second parameter is performed on the basis of the values of the load capacity determined in the first step for different values of the second parameter by calculation or by interpolation or extrapolation.