Publication number: 20230203430
Abstract: The present disclosure provides an engineered microorganism capable of producing malonic acid, malonate, esters of malonic acid, or mixtures thereof. The engineered microorganism includes a malonate-semialdehyde dehydrogenase that is heterologous to a native form of the engineered microorganism and comprises at least 90% sequence identity to any one of SEQ ID Nos: 7, 9, 11, 13, 15, 17, 19, 21, 23, 27, 29, and 31, wherein the engineered microorganism is capable of producing about 9 g/L to about 250 g/L of malonic acid, malonate, esters of malonic acid, or mixtures thereof.
Type:
Application
Filed:
December 21, 2020
Publication date:
June 29, 2023
Applicant:
CARGILL, INCORPORATED
Inventors:
Keith Michael BRADY, Cathy Staloch HASS, Peter Alan JAUERT, Nandita KOHLI, Briana Kristen KOZLOWICZ, Hans H. LIAO, Michael Tai Man LOUIE, Michiel MATTHIJS, Naga Sirisha PARIMI, Catherine Bradshaw POOR, Brian Jeffrey RUSH, Travis Tobert WOLTER