Abstract: At a high level, disclosed herein is a bioprinter configured to fabricate a single but highly complex and multi-material regenerative scaffold compared to a more traditional approach of mass production of simple shapes. In an embodiment, printer may include a multi-head, multi-axial bio-printer for extrusion printing and laser manipulation of scaffold and/or organic materials specific to a particular tissue such as without limitation customized vascularized bone graft or joint replacement tissue. Printer may facilitate controlled deposition of cells, biologics, and/or scaffold and organic materials in controlled, mixed gradients.

Abstract: The present disclosure is directed towards genetically engineered TCR-T cells to recognize tumor antigens and simultaneously secrete a binding protein that blocks an immune checkpoint molecule and TGF?. These engineered T cells demonstrate stronger antitumor response and reduced T cell exhaustion. The present disclosure provides immunotherapy against HPV- or EBV-positive cancers, among others.

Abstract: Disclosed herein are various bioreactor devices and systems for growing cellular material, and related methods of growing cellular material. In some cases, a system can include a well plate having a plurality of wells and a bioreactor situated in each well of the well plate. In some cases, a bioreactor can include an inner body which divides the bioreactor into several distinct chambers and facilitates the growth of a multi-tissue sample in the bioreactor. In some cases, a system can include a mechanical actuator situated to mechanically stress tissues grown in a bioreactor.

Abstract: The present disclosure provides compositions comprising anti-LMP2 TCR-T cell populations for the treatment of EBV-associated cancers and methods of making and using same.

Abstract: A security device, such as a passive infra-red motion detector (1) is provided with a plurality of fasteners (15, 25). One fastener (25) removably fastens a lens (4) to a housing of the passive infra-red detector, such that the lens (4) can be removed from the outside of the housing, whilst the other fastener (15) fastens a front section (2) of the housing to the rear section (3). Both fasteners (15, 25) are transparent/translucent and act as light guides.

Abstract: A guidance system for guiding a clinician in delivering a needle to a target location within a hollow organ in a patient's body. The guidance system includes: a computing device; a target sensor configured to provide target sensor data describing the position of the target sensor, wherein the target sensor is configured to be positioned at or proximate to the target location within the hollow organ; a needle sensor configured to be carried by the needle or a device on which the needle is mounted, and to provide needle sensor data describing the position and orientation of the needle; at least one information delivery device configured to deliver information to the clinician.

Abstract: Disclosed herein are various bioreactor devices and systems for growing cellular material, and related methods of growing cellular material. In some cases, a system can include a well plate having a plurality of wells and a bioreactor situated in each well of the well plate. In some cases, a bioreactor can include an inner body which divides the bioreactor into several distinct chambers and facilitates the growth of a multi-tissue sample in the bioreactor. In some cases, a system can include a mechanical actuator situated to mechanically stress tissues grown in a bioreactor.

Abstract: Disclosed herein are various bioreactor devices and systems for growing cellular material, and related methods of growing cellular material. In some cases, a system can include a well plate having a plurality of wells and a bioreactor situated in each well of the well plate. In some cases, a bioreactor can include an inner body which divides the bioreactor into several distinct chambers and facilitates the growth of a multi-tissue sample in the bioreactor. In some cases, a system can include a mechanical actuator situated to mechanically stress tissues grown in a bioreactor.

Abstract: At a high level, disclosed herein is a bioprinter configured to fabricate a single but highly complex and multi-material regenerative scaffold compared to a more traditional approach of mass production of simple shapes. In an embodiment, printer may include a multi-head, multi-axial bio-printer for extrusion printing and laser manipulation of scaffold and/or organic materials specific to a particular tissue such as without limitation customized vascularized bone graft or joint replacement tissue. Printer may facilitate controlled deposition of cells, biologics, and/or scaffold and organic materials in controlled, mixed gradients.

Abstract: A security device, such as a passive infra-red motion detector (1) is provided with a plurality of fasteners (15, 25). One fastener (25) removably fastens a lens (4) to a housing of the passive infra-red detector, such that the lens (4) can be removed from the outside of the housing, whilst the other fastener (15) fastens a front section (2) of the housing to the rear section (3). Both fasteners (15, 25) are transparent/translucent and act as light guides.

Abstract: Disclosed herein are various bioreactor devices that mimic the mammalian joint. The bioreactor device can include a series of bioreactor chambers that contain different components of the joint, such as bone, cartilage, synovium, nerve and ligament. At least two different nutrient fluid circulation systems connect subsets of the bioreactor chambers to differentially supply nutrient fluids at concentrations optimized for the tissue that the fluid nourishes. For example, relatively hypoxic fluid can be supplied to synovium and cartilage to mimic oxygenation in the joint compartment, but normoxic fluid can be supplied to the bone and other components that have an arterial supply that provides higher oxygen concentrations. One or more or all of the bioreactor chambers can be supplied with separate inlets through which perturbation agents (such as drugs or other agents) can be introduced to model the effect of the perturbations on different components of the system.

Abstract: A wireless mesh network comprises a controller and a plurality of wireless networked devices arranged to transmit messages to and receive messages from the controller. The plurality of devices are arranged in zones, such that a device that is arranged to communicate directly with the controller is designated a “Zone 1” device and a device that is arranged to communicate with the controller via a “Zone 1” device is designated a “Zone 2” device. One or more or each of the plurality of devices periodically sends a positioning message to the controller to determine its zone and if it can communicate directly with the controller it determines that it is a “Zone 1” device and if it cannot communicate directly with the controller, but it can communicate with the controller via a “Zone 1” device and therefore arranged to do so, it determines that it is a “Zone 2” device.

Abstract: Methods for inhibiting tissue ossification or calcification in a subject, comprising administering a therapeutically effective amount of BMP I inhibitor-loaded microparticles to a subject in need thereof, wherein the administration provides local and sustained release of the BMP I inhibitor thereby inhibiting tissue ossification or calcification.

Abstract: The disclosure relates to anti-ALPP CAR-T cell therapies for the treatment of cancer patients having ALPP-positive cancer, including e.g., ovarian, endometrial, cervical, testicular cancers, etc.

Abstract: The present disclosure provides compositions comprising anti-LMP2 TCR-T cell populations for the treatment of EBV-associated cancers and methods of making and using same.

Abstract: The present disclosure is directed towards genetically engineered TCR-T cells to recognize tumor antigens and simultaneously secrete a binding protein that blocks an immune checkpoint molecule and TGF-beta. These engineered T cells demonstrate stronger antitumor response and reduced T cell exhaustion. The present disclosure provides immunotherapy against HPV- or EBV-positive cancers, among others.

Abstract: Disclosed herein are various bioreactor devices and systems for growing cellular material, and related methods of growing cellular material. In some cases, a system can include a bioreactor system having one or more wells with at least one fluidic passageway coupled to each well to feed fluids to biological material being developed inside the well. In some cases, a bioreactor system can include a main body comprising the perimeter of the well and the fluidic passageways, a cover that forms the top of the well and provides optical access into the well, and a base that forms the bottom surface of the well. The cover and base can be attached and detached from the main body to seal the well closed and to physically access the contents of the well.

Abstract: Disclosed herein are various bioreactor devices and systems for growing cellular material, and related methods of growing cellular material. In some cases, a system can include a well plate having a plurality of wells and a bioreactor situated in each well of the well plate. In some cases, a bioreactor can include an inner body which divides the bioreactor into several distinct chambers and facilitates the growth of a multi-tissue sample in the bioreactor. In some cases, a system can include a mechanical actuator situated to mechanically stress tissues grown in a bioreactor.

Abstract: Disclosed herein are various bioreactor devices and systems for growing cellular material, and related methods of growing cellular material. In some cases, a system can include a well plate having a plurality of wells and a bioreactor situated in each well of the well plate. In some cases, a bioreactor can include an inner body which divides the bioreactor into several distinct chambers and facilitates the growth of a multi-tissue sample in the bioreactor. In some cases, a system can include a mechanical actuator situated to mechanically stress tissues grown in a bioreactor.

Abstract: A mesh network comprises a controller and a plurality of mesh-networked devices, operable to communicate with the controller. The controller and the plurality of mesh-networked devices comprise timing units, and are operable to communicate in accordance with a frequency hopping sequence. The mesh-networked devices switch between a transmit mode, in which they are capable of transmitting messages to one or more other mesh-networked device and/or the controller and an inactive mode, in which they are unable to transmit to or receive messages from one or more other mesh-networked devices or the controller. The timing units of the mesh-networked devices are synchronised and the mesh-networked devices are operable to switch to the transmit mode at pseudorandom time intervals.