Abstract: The subject matter described herein is directed to ferroportin inhibitor compounds of Formula I or I? and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds, and methods of administering the compounds for prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, particularly iron overload states, such as thalassemia, sickle cell disease and hemochromatosis, and also kidney injuries.

Abstract: A sensor element for detecting a level of a gas component in the measured gas or a temperature of the measured gas. The sensor element includes at least one solid electrolyte layer. The solid electrolyte layer has at least one plated-through hole. The sensor element further includes a conductive element, which produces an electrically conductive connection through the plated-through hole. In the plated-through hole, the solid electrolyte layer is electrically insulated from the conductive element by an insulating element. At least one opening region of the plated-through hole is stabilized against phase transition by a stabilizing element. The stabilizing element is made at least partially of a material, which includes a noble metal and an element selected from the group consisting of: V, Nb, Ta, Sb, Bi, Cr, Mo, W. A method for manufacturing the sensor element is also provided.

Abstract: A sensor element for detecting a level of a gas component in the measured gas or a temperature of the measured gas. The sensor element includes at least one solid electrolyte layer. The solid electrolyte layer has at least one plated-through hole. The sensor element further includes a conductive element, which produces an electrically conductive connection through the plated-through hole. In the plated-through hole, the solid electrolyte layer is electrically insulated from the conductive element by an insulating element. At least one opening region of the plated-through hole is stabilized against phase transition by a stabilizing element. The stabilizing element is made at least partially of a material, which includes a noble metal and an element selected from the group consisting of: V, Nb, Ta, Sb, Bi, Cr, Mo, W. A method for manufacturing the sensor element is also provided.

Abstract: The invention relates to a continuous process for preparing polyolefins having a bimodal or multimodal molar mass distribution in suspension in at least two reactors R1, R2.x, R3.y which are connected in series and in which different reaction conditions are set. In this process, the offgases A1, A2.x, A3.y, A4 and A5 leaving all the reactors connected in series are firstly collected, the collected offgases are then compressed in a compression stage 10, the compressed offgases are subsequently cooled and the cooled material is separated into a gaseous fraction and a liquid fraction. The separated fractions are then recirculated to the polymerization process at different points. The process of the invention allows the total conversion of the polymerization, based on monomer and comonomer used, to be increased to a surprising extent.

Abstract: The coating of the cylindrical periphery of engine pistons with coating compound, in particular low friction materials, is performed by means of screen printing. The pistons can be coated in the vertical position around their vertical central longitudinal axis as they rotate past a screen printing stencil.