Abstract: An improved design and method is disclosed to disassemble a milling machine for transport and to reassemble it when transport is complete. The invention essentially comprises a hinge located at the bottom of the mill column to facilitate the disassembly and subsequent reassembly of the mill column from the mill base. The hinge protects the precise alignment surfaces at the bottom of the mill column and the top of the mill base from damage during both assembly and disassembly. In addition, it guides and stabilizes the column which makes it easier to remove and reattach the mill column to the mill base. By separating the milling machine into two components transportation is made easier and it becomes possible to install a milling in many locations that were previously inaccessible. The simplicity of the method will be advantageous for shops where space constraints make milling machine installation difficult.

Abstract: Therapeutic vaccines comprising polypeptides expressed during the latent stage of mycobacteria infection are provided, as are multiphase vaccines, and methods for treating and preventing tuberculosis.

Abstract: This invention relates to a polypeptide fragment which comprises an amino acid sequence encoded by a member of the esat-6 gene. A member of the esat-6 gene family is defined as gene encoding a small protein and that two such genes are arranged next to each other on the genome and that at least one of the gene products has an amino acid sequence identity to either Rv3874, Rv3875, or Rv0288 of at least 15%.

Abstract: Here we identify MMG and its alpha- and ketomycolic acid derivatives as highly bioactive lipids derived from M. bovis BCG (Copenhagen) capable of stimulating and activating human DC's at exceedingly low doses. In addition to their direct role as immunostimulators of human DC's we demonstrate their use in the development of a new generation of adjuvants suitable for human administration. We furthermore identify a number of highly active synthetic MMG analogues with great potential in cancer treatment, and for vaccine adjuvants against both infectious disease and disorders like Alzheimers disease.

Abstract: An oral care implement is provided having a handle and a head with a soft tissue cleanser and/or tooth cleaning elements. The tooth cleaning elements may be flexibly mounted in the head for movement from an initial position with respect to the head during use. The soft tissue cleanser may include a plurality of projections for cleaning the soft tissue. The soft tissue cleanser may include a face having hills and valleys upon which the projections are located. The handle may include a base with a gripping region and a projection protruding from the base in the gripping region. The handle may also have a grip surface with a plurality of spaced slot openings exposing portions of the base. The grip body may form opposite finger grips on the handle.

Abstract: The currently used method for immunological diagnosis of tuberculosis infection, the tuberculin skin test, is problematic for a number of reasons; it has low specificity in BCG vaccinated individuals, a high interobserver variance and requires skill to be read and interpreted. Furthermore it requires an extra visit to the clinic to have the test read. Both people vaccinated with BCG and those exposed to non-tuberculosis mycobacteria give a positive skin test result similar to that seen in a TB infected individual. This also applies for purified protein derivative (PPD) when used in a blood cell based test. The present invention discloses the development of an immunological TB diagnostic tool based on a combination of epitopes from proteins encoded by regions of the M. tuberculosis (M. tub.) genome, that are not present in the BCG vaccine strain or in the most common non-tuberculosis mycobacteria.

Abstract: A method for evaluating an electrocardiogram is disclosed herein. The method includes measuring an electrical activity of a patient, processing the measured electrical activity to form a multi-lead signal, and extracting a segment of the multi-lead signal. The method for evaluating an electrocardiogram also includes transforming the segment of the multi-lead signal into a synthesized signal that is most representative of the patient's electrical activity, and evaluating the synthesized signal. A corresponding system for evaluating an electrocardiogram is also disclosed.

Abstract: An adjuvant combination and a kit useful for immunization is provided. The kit contains an antigenic substance and an adjuvant combination of dimethyl dioctadecyl ammonium bromide (DDA-Br or DDA-Cl) with a monophosphoryl lipid.

Abstract: An oral care implement having a handle and a head having a flexible support from which cleaning elements extend. In one aspect, the invention can be an oral care implement comprising: a handle; a head attached to the handle; a flexible support attached to the head and having a face; a plurality of cleaning elements attached to the flexible support and projecting outwardly from the face, the cleaning elements including bristles and wall-like elements and being movable in the outward direction from the head; wherein the cleaning elements comprise a row of first cleaning elements substantially aligned along a longitudinal axis of the head and traversing a central region of the flexible support; and wherein some of the wall-like cleaning elements laterally radiate from the central region of the flexible support.

Abstract: The present invention relates to liposome formulations that are physically stable. In particular the present invention relates to steric stabilization of cationic liposomes by incorporating glycolipids into the liposomes. The stabilized liposomes can be used either as an adjuvant for antigenic components or as a drug delivery system. In particular the invention relates to vaccines with adjuvants in aqueous media for immunization, where the final product is stable.

Abstract: The present invention relates to liposome formulations that are physically stable. In particular the present invention relates to steric stabilization of cationic liposomes by incorporating glycolipids into the liposomes. The stabilized liposomes can be used either as an adjuvant for antigenic components or as a drug delivery system. In particular the invention relates to vaccines with adjuvants in aqueous media for immunization, where the final product is stable.

Abstract: The present invention relates to a system and a method for analysis of ECG curvature, which system involves a mathematical analysis, which analysis comprises the following features where a number of different parameters are isolated and stored in computer means, where a first number of parameters are selected from at least one main group, where the selected parameters are combined in at least a first mathematical analysis. It is the object of the invention to improve mathematical analysis of ECG curvature particular for complex parts of the curvature such as notches or concavities. It is a further object of the invention to improve automatic quantification of symmetry, flatness and durations of ECG curvature.

Abstract: Vaccination with the combination of Ag85B-TB10.4 and IC31® adjuvant generated a high amount of polyfunctional CD4+T cells expressing high levels of IFN-?, TNF-?, and IL-2. This in turn led to significant protection against infection with M. tuberculosis in the mouse aerosol challenge model of tuberculosis. Both the immunogenicity of the vaccine and its ability to protect against TB infection was highly dependent on the antigen dose. Thus, whereas the standard antigen dose of 5 ?g, as well as 15 ?g, did not induce significant protection against M. tuberculosis, reducing the dose to 0.5 ?g increased both the immunogenicity of the vaccine as well as its protective efficacy to a level comparable to that observed in BCG vaccinated mice. Thus, the IC31® adjuvant, with the specified antigen dose, can induce a strong protective Th1 response against M. tuberculosis.

Abstract: The present invention is related to antigens from Chlamydia trachomatis which are recognized by specific antibodies from individuals infected with Chlamydia or which can induce T cells from the same individuals to secrete gamma-interferon. The T cell reactive antigens are present in a whole-cell lysate and have apparent molecular weights of 5-12, 16-20, 25-35 and 58-74 kDa as determined by SDS-PAGE. The antigens of the invention are useful in vaccines but also as diagnostic compositions.

Abstract: The invention relates to a fixation device (1) and a method for fixating a carcass, e.g. during processing the carcass at a slaughterhouse, such as a carcass hanging head-down from a gambrel, wherein the device (1) comprises mouth-engaging fixation means.

Abstract: The invention is related to an immunogenic composition, vaccine or pharmaceutical composition for preventing, boosting or treating infection caused by a species of the tuberculosis complex (M. tuberculosis, M. bovis, M. africanum, M. microti). The immunogenic composition, vaccine or pharmaceutical composition comprise a fusion polypeptide, which comprises one or more starvation antigens from M. tuberculosis, the units of the fusion polypeptide being M. tuberculosis antigens. Further, the invention is related to the use of a vaccine comprising a fusion polypeptide sequence or nucleic acid sequence of the invention given at the same time as BCG, either mixed with BCG or administered separately at different sites or routes for preparing said immunogenic composition, vaccine, or pharmaceutical composition.

Abstract: A system or a method for analysing ECG curvature wherein at least one among a number of different parameters is isolated, for indicating symptoms of diseases having influence on the ECG curvature. The system and method provides for objective, fast and effective indication of a number of symptoms derivable from an ECG curve which may be indicative of one or more diseases. This can be achieved when a first number of selected parameters are combined in at least a first mathematical analysis, where the result of the analysis can be represented as a point in a coordinate system comprising at least two axes where the system can compare the actual placement in the coordinate system with a number of reference parameters stored in the system for indicating diseases having influence on the ECG curvature.

Abstract: The present invention is based on the identification and characterization of a number of novel M. tuberculosis derived proteins and protein fragments. The invention is directed to the polypeptides and immunologically active fragments thereof, the genes encoding them, immunological compositions such as diagnostic reagents containing the polypeptides.

Abstract: The invention relates to a fixation device (1) and a method for fixating a carcass, e.g. during processing the carcass at a slaughterhouse, such as a carcass hanging head-down from a gambrel, wherein the device (1) comprises mouth-engaging fixation means.

Abstract: The disclosure relates to a method and aspects of an apparatus for loosening a plucks set (3) including tongue (28), heart and lungs from a suspended carcass (1). The carcass (1) may be fixed by means of mouth-engaging fixing means (10). The plucks set of the carcass (1) is cut loose by cutting means (15) that are introduced through the mouth (2) of the carcass (1), mouth-engaging fixing means (10) possibly cooperating with the cutting means (15) to ensure that e.g. the tonsils (27) or tongue (28) are not damaged. Subsequently, the tongue (28) may be loosened from the mandible (14) by scraping.