Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. The compounds provided herein can in other embodiments overcome the resistance conferred by single amino acid mutations at defined positions of bacterial Signal Peptidases (SPases) and in other embodiments provide for a broad spectrum of antibiotic bioactivity. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

Abstract: Methods, devices, and computer programs are presented for creating a unified data stream from multiple data streams acquired from multiple devices. One method includes an operation for receiving activity data streams from the devices, each activity data stream being associated with physical activity data of a user. Further, the method includes an operation for assembling the unified activity data stream for a period of time. The unified activity data stream includes data segments from the data streams of at least two devices, and the data segments are organized time-wise over the period of time.

Abstract: A method of operating a voltage regulator including a source voltage rail and a plurality of output voltage rails, the method including: converting a source voltage on the source voltage rail to a respective output voltage on each output voltage rail; selecting an output voltage rail; comparing the output voltage on the selected output voltage rail to a reference voltage for the selected output voltage rail; and if the output voltage of the selected output voltage rail is less than the reference voltage for the selected output voltage rail, controlling the voltage regulator to increase the output voltage on the selected output voltage rail, wherein the frequency at which an output voltage rail is selected is dependent upon the rate at which the voltage regulator has previously increased the output voltage on that output voltage rail.

Abstract: Embodiments for presenting search content is provided herein. An embodiment includes, receiving an input string in a browser input receiver, presenting a list of identifiers and search queries, wherein at least a portion of each of the identifiers and search queries match the input string, and presenting one or more search results associated with a selected search query on a display or providing a HTTP request to retrieve content associated with a selected identifier, and presenting the content on the display.

Abstract: A method for detecting refractive errors in the eye that are attributable to a suboptimal surface shape of the front surface and/or rear surface of the cornea. An OCT volume scan and/or one or more OCT line scans of the front eye section are carried out; using the measured values, the front and rear surface of the cornea are detected by an edge detection process; the topography of the front and rear surface of the cornea are determined; and refractive errors are determined from said topographies.

Abstract: The present disclosure is directed to a method for cleaning gas turbine engine components using an acoustic emitter. More specifically, in one embodiment, the method includes positioning the acoustic emitter at a cleaning location of a component of the gas turbine engine. For example, the cleaning location is typically characterized by having a build-up of foulants on a surface thereof. Thus, the method includes emitting, via the acoustic emitter, acoustic waves at a predetermined frequency towards the cleaning location of the component so as to disperse the foulants.

Abstract: Embodiments of the present invention include a system and method for wirelessly identifying and validating an electronic device in order to initiate a communication process with another device or a service. In an embodiment, the system includes a portable biometric monitoring device that is identified by a client device or a server for the purpose of initiating a pairing process. In an embodiment, pairing implies pairing the portable device to an online user account with minimal user interaction. After pairing, the portable device and appropriate client devices and servers communicate with little or no user interaction, for example to upload sensor data collected by the portable device.

Abstract: In implementations of creating a communication group, a mobile device can receive a selection to enable communication of location information between devices that correspond to entities from a group of entities associated with a user of the mobile device. The mobile device can receive location information that describes a physical location or proximity of the devices that correspond to the entities, and present in a user interface on a display device, a visual representation that indicates at least one of the entities is at a location within a pre-set distance of the mobile device. A communication group can be created that includes the entities selected from the group of entities associated with the user of the mobile device. The mobile device can also communicate the location information of the mobile device to all of the devices that correspond to the entities as a group communication based on the communication group.

Abstract: A computing device can be controlled based on changes in the angle of a user's head with respect to the device, such as due to the user tilting the device and/or the user tilting his head with respect to the device. Such control based on the angle of the user's head can be achieved even when the user is operating the device “off-axis” or when the device is not orthogonal and/or not centered with respect to the user. This can be accomplished by using an elastic reference point that dynamically adjusts to a detected angle of the user's head with respect to the device. Such an approach can account for differences between when the user is changing his natural resting position and/or the resting position of the device and when the user is intending to perform a gesture based on the angle of the user's head relative to the device.

Abstract: An assembler receives a circuit board. The circuit board includes at least a first node and a second node that are adjacent but electrically isolated from each other. There is a gap between the first node and the second node. The first node is electrically isolated from other components on the circuit board. The second node is electrically coupled to circuitry residing on the circuit board. The assembler initiates positioning of a conductive lead of a battery in a vicinity of the first node. The gap between the first node and second node initially prevents the live conductive lead from being in electrical contact with the second node. Eventually, the assembler bridges the gap to provide an electrical connection between at least the conductive lead and the second node to electrically couple the conductive lead to the second node and thus the circuitry residing on the circuit board.

Abstract: Applications in a broadcast environment distribute events in real-time to a large number of receivers within specified geographic locations while efficiently sharing bandwidth resources with other applications using the same broadcast network. Applications need not be aware of the other applications sharing the resources, nor of the methods, protocols, and other mechanisms used to actually broadcast the data over the broadcast medium. Server-side applications that serve data, send notifications, or distribute events to specific locations within the network use a broadcast location manager. Client applications that receive such data, notifications, or events use a client location filter to obtain events that are relevant based on the location of the device. The broadcast location manager and client location filter work together to reliably and efficiently transmit data, notifications, and events to specific locations over the broadcast network for all applications involved.

Abstract: A method of joining two components using additive manufacturing is provided. The method includes forming a first component made of a first material; forming an interlocking transition zone from the first material and a second material; and forming a second component made of the second material. The interlocking transition zone includes a plurality of projections alternately extending from the first component and the second component, respectively, to undetachably couple the first component and the second component.

Abstract: A bladed disk for a gas turbine engine is provided. The bladed disk includes a rotor disk, a plurality of rotor blades, and an interlocking transition zone. The rotor disk includes a plurality of fused layers of a first material formed via additive manufacturing and defines an outer rim. The plurality of rotor blades includes a plurality of fused layers of a second material formed via additive manufacturing. The interlocking transition zone includes a plurality of projections alternately extending from the outer rim of the rotor disk and the plurality of rotor blades, respectively, to undetachably couple the rotor disk and the plurality of rotor blades.

Abstract: Methods for repairing surface of a metal substrate are provided, which can include preparing the surface of the metal substrate for repair; melt attaching a base layer onto the surface of the metal substrate; fusing a plurality of first layers of a first material via additive manufacturing to the base coating; forming an interlocking transition zone via additive manufacturing from the first material and a second material; and fusing a plurality of second layers of the second material via additive manufacturing on the interlocking transition zone. The interlocking transition zone can have a plurality of projections alternately extending from the plurality of first layers and the plurality of second layers, respectively, to undetachably couple the plurality of first layers to the plurality of second layers. A repaired metal substrate is also provided.

Abstract: Turbine nozzles are provided for gas turbine engines. The turbine nozzle includes an arcuate inner band; an arcuate outer band; and a nozzle vane disposed between the arcuate inner band and the arcuate outer band. The radially inner end of the nozzle vane is attached to the arcuate inner band through an interlocking transition zone comprising a plurality of projections alternately extending from the radially inner end of the nozzle vane and the arcuate inner band, respectively, to undetachably couple the nozzle vane and the arcuate inner band. Optionally, the radially outer end of each nozzle vane is also attached to the arcuate outer band through an interlocking transition zone.

Abstract: A rotor blade formed via additive manufacturing is provided. The rotor blade includes an airfoil and a coupled component. The airfoil includes a plurality of fused layers of a first material formed via additive manufacturing and defines a leading edge and a tip at a distal end. The coupled component includes a plurality of fused layers of a second material formed via additive manufacturing. An interlocking transition zone includes a plurality of projections alternately extending from the airfoil and the coupled component, respectively, to undetachably couple the airfoil and the coupled component.

Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

Abstract: An apparatus and system for secure packaging, shipment, receipt and storage of mail, parcels and parcels is described. The apparatus includes an appliqué with a multitude of sensitized residue within that surround the parcel; the residue in the media forms a unique optical fingerprint, which is an exemplar image data for comparison. Substantial damage to one or more fibers alters the optical fingerprint pattern. The data is read and independently verified at waypoints and the destination. Comparing the current image data to the exemplar image data indicates damage or tampering.

Abstract: Embodiments for presenting search content is provided herein. An embodiment includes, receiving an input string in a browser input receiver, presenting a list of identifiers and search queries, wherein at least a portion of each of the identifiers and search queries match the input string, and presenting one or more search results associated with a selected search query on a display or providing a HTTP request to retrieve content associated with a selected identifier, and presenting the content on the display.

Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. The compounds provided herein can in other embodiments overcome the resistance conferred by single amino acid mutations at defined positions of bacterial Signal Peptidases (SPases) and in other embodiments provide for a broader spectrum of antibiotic bioactivity compared to the natural product. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.