Abstract: The present invention provides methods of treating non-small cell lung cancer in a patient comprising administering to the patient an effective amount of a PARP inhibitor, wherein the patient is Lung Subtyping Panel (LSP) positive.

Abstract: The present disclosure provides a method for treating a patient having cancer, such as glioblastoma. The method may comprise obtaining a biological sample from the patient, and detecting a mutation in a microtubule-related gene is present in the biological sample. The method further comprises administering an effective amount of a pharmaceutical composition comprising a tubulin polymerization inhibitor, such as an auristatin, to the patient.

Abstract: An input device has both a touch sensor and a position sensor. A computer using data from the input device uses the relative motion of a contact on a touch sensor with respect to motion from a position detector to disambiguate intentional from incidental motion. The input device provides synchronized position sensor and touch sensor data to the computer to permit processing the relative motion and performing other computations on both position sensor and touch sensor data. The input device can encode the magnitude and direction of motion of the position sensor and combines it with the touch sensor data from the same time frame, and output the synchronized data to the computer.

Abstract: The present invention relates to diagnostic assays useful in classification of patients for selection of cancer therapy with one or more Aurora kinase B inhibitors. In particular, the present invention relates to identifying the genetic defects in the CDKN2A locus which exhibit a heightened dependency on Aurora kinase activity, identifying patients eligible to receive Aurora kinase inhibitor therapy, either as monotherapy or as part of combination therapy, and monitoring patient response to such therapy.

Abstract: An input device has both a touch sensor and a position sensor. A computer using data from the input device uses the relative motion of a contact on a touch sensor with respect to motion from a position detector to disambiguate intentional from incidental motion. The input device provides synchronized position sensor and touch sensor data to the computer to permit processing the relative motion and performing other computations on both position sensor and touch sensor data. The input device can encode the magnitude and direction of motion of the position sensor and combines it with the touch sensor data from the same time frame, and output the synchronized data to the computer.

Abstract: An input device has both a touch sensor and a position sensor. A computer using data from the input device uses the relative motion of a contact on a touch sensor with respect to motion from a position detector to disambiguate intentional from incidental motion. The input device provides synchronized position sensor and touch sensor data to the computer to permit processing the relative motion and performing other computations on both position sensor and touch sensor data. The input device can encode the magnitude and direction of motion of the position sensor and combines it with the touch sensor data from the same time frame, and output the synchronized data to the computer.

Abstract: A touch sensor provides frames of touch sensor data, as the touch sensor is sampled over time. Spatial and temporal features of the touch sensor data from a plurality of frames, and contacts and attributes of the contacts in previous frames, are processed to identify contacts and attributes of the contacts in a current frame. Attributes of the contacts can include, whether the contact is reliable, shrinking, moving, or related to a fingertip touch. The characteristics of contacts can include information about the shape and rate of change of the contact, including but not limited to a sum of its pixels, its shape, size and orientation, motion, average intensities and aspect ratio.

Abstract: An input device has both a touch sensor and a position sensor. A computer using data from the input device uses the relative motion of a contact on a touch sensor with respect to motion from a position detector to disambiguate intentional from incidental motion. The input device provides synchronized position sensor and touch sensor data to the computer to permit processing the relative motion and performing other computations on both position sensor and touch sensor data. The input device can encode the magnitude and direction of motion of the position sensor and combines it with the touch sensor data from the same time frame, and output the synchronized data to the computer.

Abstract: Methods and kits for predicting the sensitivity of a cancer to treatment with a targeted tyrosine kinase inhibitor are disclosed.

Abstract: The present disclosure relates generally to the evaluation and/or treatment of a subject having or suspected of having a neoplastic condition, and in particular to the use of biomarkers for identifying patients receptive to a certain drug therapy, and which permit monitoring of patient response to such therapy.