Abstract: The present disclosure provides, at least in part, methods and compositions for in vivo fusosome delivery. In some embodiments, the fusosome comprises a combination of elements that promote specificity for target cells, e.g., one or more of a re-targeted fusogen, a positive target cell-specific regulatory element, and a non-target cell-specific regulatory element. In some embodiments, the fusosome comprises one or more modifications that decrease an immune response against the fusosome.

Abstract: This disclosure provides, e.g., cytobiologic compositions and methods of use thereof. The cytobiologics can be used, e.g., to deliver a protein or nucleic acid to a target cell.

Abstract: A tool for spreading mortar in laying bricks or blocks and a method for using such a tool are disclosed. The tool comprises a body that has a long axis, wherein transverse to the long axis, the body has a cross-section that defines a chamber under a flat upper wall and between side walls, the chamber having a height that decreases from a leading edge to a trailing edge of the upper wall. In the method, the tool is placed such that the chamber substantially spans the layer of mortar, and moving the tool along the layer of mortar with the leading foremost while applying a force to the tool in a direction substantially normal to the upper wall, whereby the mortar layer is formed into a mortar bed.

Abstract: Apparatus for sealing an aperture against ingress of floodwater is disclosed. The apparatus comprising a cover portion for covering and forming a seal around an aperture, and location means for engaging with a component associated with the aperture to retain the cover portion in place. For example, the locating means may include a securing element that engages with the fixed component, and screw threaded components to draw the cover portion into place. Embodiments of the invention may be applied to seal an aperture such as an airbrick, a wastewater outlet, an overflow, etc. Further apparatus comprises a sealing portion and a securing portion whereby the apparatus can be disposed for use in a toilet bowl such that the sealing portion is retained in position by the securing portion to substantially seal an outlet of the toilet bowl. Once the risk of flooding has passed, the apparatus can be removed.

Abstract: A flood protection barrier is disclosed that can be deployed in the event of an immanent flood risk. The barrier comprises a shield having a sealing element and securing means for securing the shield in place to at least partially close an aperture in a wall of a building. The sealing element forms a fluid-resistant seal between barrier and the periphery of the aperture thereby resisting passage of water through the aperture. The barrier can be secured by securing means that require no modification to the building. The securing means may include clip assemblies or, in alternative embodiments, wedges or other suitable components.

Abstract: A flood protection barrier is disclosed that can be deployed in the event of an immanent flood risk. The barrier comprises a shield having a sealing element and securing means for securing the shield in place to at least partially close an aperture in a wall of a building. The sealing element forms a fluid-resistant seal between barrier and the periphery of the aperture thereby resisting passage of water through the aperture. The barrier can be secured by securing means that require no modification to the building. The securing means may include clip assemblies or, in alternative embodiments, wedges or other suitable components.

Abstract: Apparatus for sealing an aperture against ingress of floodwater is disclosed. The apparatus comprising a cover portion for covering and forming a seal around an aperture, and location means for engaging with a component associated with the aperture to retain the cover portion in place. For example, the locating means may include a securing element that engages with the fixed component, and screw threaded components to draw the cover portion into place. Embodiments of the invention may be applied to seal an aperture such as an airbrick, a wastewater outlet, an overflow, etc. Further apparatus comprises a sealing portion and a securing portion whereby the apparatus can be disposed for use in a toilet bowl such that the sealing portion is retained in position by the securing portion to substantially seal an outlet of the toilet bowl. Once the risk of flooding has passed, the apparatus can be removed.