Abstract: A floor joist system (9) comprises a flat sheet metal structural web member (10) for interconnecting a pair of parallel spaced apart wood chord members (11), said web member (10) being V-shaped, comprising first and second legs (12, 13) integrally joined at one of their respective ends, a plurality of teeth struck from said one end of each leg (12, 13) and extending from one face, constituting the inside face, of the web member (10), said teeth being adapted to be driven into one of the chord members (11), and a plurality of teeth struck from the other end of each leg and extending from the inside face of the web member (10), said teeth being adapted to be driven into the other of said chord members (11). The system further comprises a bracket (1) for holding a suspended ceiling.

Abstract: The present invention is directed to a solid and substantially amorphous active pharmaceutical ingredient, to an oral pharmaceutical formulation comprising said substantially amorphous active pharmaceutical ingredient, as well as to a method for the manufacture of the same. The invention is also directed to the use of a particulate anhydrous and substantially amorphous mesoporous magnesium carbonate (MMC) to stabilize an active pharmaceutical ingredient (API).

Abstract: The present invention is directed to a solid and substantially amorphous active pharmaceutical ingredient, to an oral pharmaceutical formulation comprising said substantially amorphous active pharmaceutical ingredient, as well as to a method for the manufacture of the same. The invention is also directed to a particulate anhydrous and substantially amorphous mesoporous magnesium carbonate (MMC), to a method for the manufacture thereof, and the use of said particulate anhydrous and substantially amorphous mesoporous magnesium carbonate (MMC) to stabilize an active pharmaceutical ingredient (API).

Abstract: The present invention relates to novel chemical compounds formula (I) (C)n—B-(A)m-B—(C)n (I) wherein m is 0 or 1, and n is independently 0, 1, 2 or 3, A, each B and each C are independently selected from phenylene and five- and six-membered heteroaromatic rings, and for a terminal ring B or C also from bicyclic heteroaromatic fused rings having seven to ten ring members, wherein the bond between at least two of the rings A to C may be replaced by a carbonyl group (—CO—), wherein at least two of the rings A to C are substituted with one or two groups R, and wherein each ring A to C further optionally is substituted with one or two groups R1. The compounds are useful in therapy, especially therapy of a mammal suffering from a disease involving misfolded or aggregated forms of proteins.

Abstract: A method for separation of an aggregated misfolded protein from an environment including a non-aggregating normal form of the protein includes contacting both the misfolded and normal protein with a conjugated polyelectrolyte (CPE) and separating the CPE/protein complex from the other constituents of the sample.

Abstract: The present invention relates to novel substituted thiophene derivatives useful in therapy of diseases related to misfolded and aggregated proteins.

Abstract: The invention relates to an elastomeric device (105), wherein the elastomeric device contains a relief structure with indentations with respect to the base (110), (102) and wherein selected ones of said indentations comprise at least two indentation depths (112), (108) and indentation widths (101), (107). It also relates to a method of making a master for construction of said elastomeric device comprising a procedure to provide a pattern on a substrate of a suitable material. One step in. the construction of said elastomeric device comprises a molding procedure of an elastomer. Methods of using the elastomeric device in printing, fluidic control, sorting, lab-on-a-chip devices are also disclosed.

Abstract: The invention relates to methods for measuring conformational changes and self-assembly/aggregation of proteins, especially the formation of amyloid fibrils, using conjugated polyelectrolytes. The conjugate polyelectrolyte is exposed to the protein whereby the conjugated polyelectrolyte and the protein of interest interact, and a change of a property of the polyelectrolyte in response to conformational changes of the protein is observed. The detected change is used to determine different conformations of the protein, especially the formation of amyloid fibrils.

Abstract: A method for separation of an aggregated misfolded protein from an environment including a non-aggregating normal form of the protein includes contacting both the misfolded and normal protein with a conjugated polyelectrolyte (CPE) and separating the CPE/protein complex from the other constituents of the sample.

Abstract: A method for treatment of a disease caused by aggregation of misfolded proteins including subjecting a body fluid of a patient to a separation of an aggregated misfolded protein which includes contacting both the misfolded and normal protein with a conjugated polyelectrolyte (CPE) and separating the CPE/protein complex from the other constituents of the sample.

Abstract: The invention relates to an elastomeric device (105), wherein the elastomeric device contains a relief structure with indentations with respect to the base (110), (102) and wherein selected ones of said indentations comprise at least two indentation depths (112), (108) and indentation widths (101), (107). It also relates to a method of making a master for construction of said elastomeric device comprising a procedure to provide a pattern on a substrate of a suitable material. One step in. the construction of said elastomeric device comprises a molding procedure of an elastomer. Methods of using the elastomeric device in printing, fluidic control, sorting, lab-on-a-chip devices are also disclosed.

Abstract: The invention relates to methods for measuring conformational changes and self-assembly/aggregation of proteins, especially the formation of amyloid fibrils, using conjugated polyelectrolytes. The conjugate polyelectrolyte is exposed to the protein whereby the conjugated polyelectrolyte and the protein of interest interact, and a change of a property of the polyelectrolyte in response to conformational changes of the protein is observed. The detected change is used to determine different conformations of the protein, especially the formation of amyloid fibrils.

Abstract: A patterned substrate for biosensing applications, wherein the pattern includes hydrophilic and hydrophobic areas, and selected ones of the areas include at least at least one reporter molecule, a property of which is detectable. A method of making a patterned substrate includes performing a stamping procedure to provide a pattern of hydrophilic and hydrophobic areas on a substrate of a suitable material. One step of the stamping procedure includes attaching at least one reporter molecule to at least selected ones of the areas, the fluorescence of the conjugated polyelectrolyte being detectable and which will change as a result of interaction with a biomolecule.