Patents by Inventor Peter B. Heifetz
Peter B. Heifetz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240358844Abstract: The present invention is related to a drug delivery composition that includes a thioredoxin homologue protein having an N-terminal monocysteinic active site, with the cysteine residue of the active site in a reduced state and an active agent conjugated to the thioredoxin homologue protein and methods of making and using the composition.Type: ApplicationFiled: June 4, 2024Publication date: October 31, 2024Applicant: ORPRO THERAPEUTICS, INC.Inventors: Peter B. HEIFETZ, Haim MOSKOWITZ
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Publication number: 20230071765Abstract: The present disclosure relates to preparations, formulations and uses of a protein or peptide having thioredoxin action for treating diseases and/or conditions. One aspect of the invention is a method to decrease viscoelasticity of mucus or sputum in a patient that has excessively viscous or cohesive mucus or sputum. The method includes contacting the mucus or sputum of the patient with a composition comprising a protein or peptide comprising a thioredoxin monocysteinic active site, wherein the protein or peptide does not contain any cysteine residues except for a single Cys at the N-terminal position of the thioredoxin monocysteinic active site.Type: ApplicationFiled: January 4, 2021Publication date: March 9, 2023Inventors: Peter B. Heifetz, Haim Moskowitz
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Publication number: 20210254025Abstract: Disclosed are compositions and methods for decreasing the viscosity and/or cohesiveness of and/or increasing the liquefaction of excessively or abnormally viscous or cohesive mucus or sputum. The composition contains a protein or peptide containing a thioredoxin monocysteinic active site in a reduced state and optionally further contains a reducing system.Type: ApplicationFiled: November 23, 2020Publication date: August 19, 2021Inventor: Peter B. Heifetz
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Publication number: 20210213134Abstract: The present invention is related to a drug delivery composition that includes a thioredoxin homologue protein having an N-terminal monocysteinic active site, with the cysteine residue of the active site in a reduced state and an active agent conjugated to the thioredoxin homologue protein and methods of making and using the composition.Type: ApplicationFiled: May 17, 2019Publication date: July 15, 2021Inventors: Peter B. HEIFETZ, Haim MOSKOWITZ
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Publication number: 20160230149Abstract: Disclosed are compositions and methods for decreasing the viscosity and/or cohesiveness of and/or increasing the liquefaction of excessively or abnormally viscous or cohesive mucus or sputum. The composition contains a protein or peptide containing a thioredoxin monocysteinic active site in a reduced state and optionally further contains a reducing system.Type: ApplicationFiled: September 11, 2015Publication date: August 11, 2016Inventor: Peter B. Heifetz
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Patent number: 9168290Abstract: Disclosed are compositions and methods for decreasing the viscosity and/or cohesiveness of and/or increasing the liquefaction of excessively or abnormally viscous or cohesive mucus or sputum. The composition contains a protein or peptide containing a thioredoxin monocysteinic active site in a reduced state and optionally further contains a reducing system.Type: GrantFiled: March 17, 2014Date of Patent: October 27, 2015Assignee: OrPro Therapeutics, Inc.Inventor: Peter B. Heifetz
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Publication number: 20140271599Abstract: Disclosed are compositions and methods for decreasing the viscosity and/or cohesiveness of and/or increasing the liquefaction of excessively or abnormally viscous or cohesive mucus or sputum. The composition contains a protein or peptide containing a thioredoxin monocysteinic active site in a reduced state and optionally further contains a reducing system.Type: ApplicationFiled: March 17, 2014Publication date: September 18, 2014Applicant: OrPro Therapeutics, Inc.Inventor: Peter B. Heifetz
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Patent number: 8481810Abstract: The instant disclosure describes the application of genetic engineering techniques to produce cellulase in plants. Cellulase coding sequences operably linked to promoters active in plants may be transformed into the nuclear genome and/or the plastid genome of a plant. As cellulases may be toxic to plants, chemically-inducible or wound-inducible promoters may be employed. Additionally, the expressed cellulases may be targeted to vacuoles or other cellular organelles.Type: GrantFiled: June 21, 2007Date of Patent: July 9, 2013Assignee: Syngenta Participations AGInventors: Edouard G. Lebel, Peter B. Heifetz, Eric R. Ward, Scott J. Uknes
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Patent number: 7361806Abstract: The instant disclosure describes the application of genetic engineering techniques to produce cellulase in plants. Cellulase coding sequences operably linked to promoters active in plants may be transformed into the nuclear genome and/or the plastid genome of a plant. As cellulases may be toxic to plants, chemically-inducible or wound-inducible promoters may be employed. Additionally, the expressed cellulases may be targeted to vacuoles or other cellular organelles.Type: GrantFiled: July 9, 2001Date of Patent: April 22, 2008Assignee: Syngenta Participations AGInventors: Edouard G Lebel, Peter B Heifetz, Eric R Ward, Scott J Uknes
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Publication number: 20020073443Abstract: Disclosed are novel DNA sequences isolated from soybean, wheat, cotton, sugar beet, rape, rice, sorghum, and sugar cane encode enzymes having protoporphyrinogen oxidase (protox) activity. In addition, modified, herbicide-tolerant forms of protox enzymes are disclosed. Plants expressing herbicide-tolerant protox enzymes taught herein are also provided. These plants may be engineered for resistance to protox inhibitors via mutation of the native protox gene to a resistant form or they may be transformed with a gene encoding an inhibitor-resistant from of a plant protox enzyme. Further disclosed is a method of achieving herbicide tolerance through plastid transformation, which involves transforming plastids with a chimeric gene that comprises a plastid-active promoter operatively linked to a DNA molecule that encodes a plastid-targeted enzyme whose native plastid transit peptide is either mutated so as to be nonfunctional or is absent altogether.Type: ApplicationFiled: December 6, 2000Publication date: June 13, 2002Inventors: Peter B. Heifetz, Sandra L. Volrath, Marie A. Johnson, Eric R. Ward
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Publication number: 20020062502Abstract: The invention provides novel methods of controlling gene expression in plastids, using an inducible, transactivator-mcdiated system, and plants comprising the novel expression systems. The present invention further describes the production of cellulose-degrading enzymes in plants via the application of genetic engineering techniques. Cellulase coding sequences are fused to promoters active in plants and transformed into the nuclear genome and the chloroplast genome. As cellulases may be toxic to plants, preferred promoters are those that are chemically-inducible. In this manner, expression of the cellulase genes transformed into plants may be chemically induced at an appropriate time. In addition, the expressed cellulases may be targeted to vacuoles or other organelles to alleviate toxicity problems. The present invention finds utility in any industrial process requiring a plentiful supply of cellulases, but particularly finds utility in the conversion of cellulosic biomass to ethanol.Type: ApplicationFiled: July 9, 2001Publication date: May 23, 2002Inventors: Edouard G. Lebel, Peter B. Heifetz, Eric R. Ward, Scott J. Uknes
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Patent number: 6308458Abstract: The present invention relates to methods for controlling the growth of undesired vegetation comprising applying an effective amount of a protox-inhibiting herbicide to a population of transgenic plants or plant seed transformed with a DNA sequence coding for a modified protox enzyme that is tolerant to a protox-inhibiting herbicide or to the locus where a population of the transgenic plants or plant seeds is cultivated.Type: GrantFiled: February 3, 2000Date of Patent: October 30, 2001Assignee: Novartis Finance CorporationInventors: Sandra L. Volrath, Marie A. Johnson, Eric R. Ward, Peter B. Heifetz
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Patent number: 6084155Abstract: The present invention provides novel DNA sequences coding for protoporphyrinogen oxidase (protox) enzymes from soybean, wheat, cotton, sugar beet, oilseed rape, rice, sorghum, and sugar cane. In addition, the present invention teaches modified forms of protox enzymes that are herbicide tolerant. Plants expressing herbicide tolerant protox enzymes taught herein are also provided. These plants may be engineered for resistance to protox inhibitors via mutation of the native protox gene to a resistant form or they may be transformed with a gene encoding an herbicide tolerant form of a plant protox enzyme.Type: GrantFiled: June 22, 1998Date of Patent: July 4, 2000Assignee: Novartis AGInventors: Sandra L. Volrath, Marie A. Johnson, Eric R. Ward, Peter B. Heifetz
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Patent number: 6023012Abstract: The present invention provides novel DNA sequences isolated from soybean, wheat, cotton, sugar beet, rape, rice, sorghum, and sugar cane that coding for enzymes having protoporphyrinogen oxidase (protox) activity. In addition, the present invention teaches modified forms of protox enzymes that are herbicide tolerant. Plants expressing herbicide tolerant protox enzymes taught herein are also provided. These plants may be engineered for resistance to protox inhibitors via mutation of the native protox gene to a resistant form or they may be transformed with a gene encoding an inhibitor-resistant from of a plant protox enzyme.Type: GrantFiled: March 30, 1998Date of Patent: February 8, 2000Assignee: Novartis Finance CorporationInventors: Sandra L. Volrath, Marie A. Johnson, Sharon L. Potter, Eric R. Ward, Peter B. Heifetz
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Patent number: 5939602Abstract: The present invention provides novel DNA sequences coding for plant protoporphyrinogen oxidase (protox) enzymes from soybean, wheat, cotton, sugar beet, rape, rice and sorghum. In addition, the present invention teaches modified forms of protox enzymes that are herbicide tolerant. Plants expressing herbicide tolerant protox enzymes taught herein are also provided. These plants may be engineered for resistance to protox inhibitors via mutation of the native protox gene to a resistant form or they may be transformed with a gene encoding an inhibitor-resistant from of a plant protox enzyme.Type: GrantFiled: February 28, 1997Date of Patent: August 17, 1999Assignee: Novartis Finance CorporationInventors: Sandra L. Volrath, Marie A. Johnson, Eric R. Ward, Peter B. Heifetz