Patents by Inventor Peter B. STRANGES

Peter B. STRANGES has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NON-STANDARD AMINO ACID CONTAINING COMPOSITIONS AND USES THEREOF
    Publication number: 20230257724
    Abstract: Provided herein is a stabilized DNase I polypeptide containing a non-standard amino acid that maintains enzymatic activity even under harsh conditions, such as reducing environments. The stabilized DNase I polypeptide has enzymatic activity in reducing environments that is higher than a corresponding DNase I polypeptide without the non-standard amino acids under the same conditions. Also provided herein are polynucleotides encoding the stabilized DNase I polypeptide, cells for expressing and/or producing the stabilized DNase I polypeptide, and methods of use of the stabilized DNase I polypeptide.
    Type: Application
    Filed: January 13, 2023
    Publication date: August 17, 2023
    Inventors: Daniel J. Mandell, Christopher J. Gregg, Peter B. Stranges
  • Non-standard amino acid containing compositions and uses thereof
    Patent number: 11584921
    Abstract: Provided herein is a stabilized DNase I polypeptide containing a non-standard amino acid that maintains enzymatic activity even under harsh conditions, such as reducing environments. The stabilized DNase I polypeptide has enzymatic activity in reducing environments that is higher than a corresponding DNase I polypeptide without the non-standard amino acids under the same conditions. Also provided herein are polynucleotides encoding the stabilized DNase I polypeptide, cells for expressing and/or producing the stabilized DNase I polypeptide, and methods of use of the stabilized DNase I polypeptide.
    Type: Grant
    Filed: January 8, 2021
    Date of Patent: February 21, 2023
    Assignee: GRO Biosciences Inc.
    Inventors: Daniel J. Mandell, Christopher J. Gregg, Peter B. Stranges
  • NON-STANDARD AMINO ACID CONTAINING COMPOSITIONS AND USES THEREOF
    Publication number: 20210371838
    Abstract: Provided herein is a stabilized DNase I polypeptide containing a non-standard amino acid that maintains enzymatic activity even under harsh conditions, such as reducing environments. The stabilized DNase I polypeptide has enzymatic activity in reducing environments that is higher than a corresponding DNase I polypeptide without the non-standard amino acids under the same conditions. Also provided herein are polynucleotides encoding the stabilized DNase I polypeptide, cells for expressing and/or producing the stabilized DNase I polypeptide, and methods of use of the stabilized DNase I polypeptide.
    Type: Application
    Filed: January 8, 2021
    Publication date: December 2, 2021
    Inventors: Daniel J. Mandell, Christopher J. Gregg, Peter B. Stranges
  • ENZYME SCREENING METHODS
    Publication number: 20200283842
    Abstract: The present disclosure is directed to compositions and methods for deriving a plurality of kinetics parameters (240) for at least two different enzyme variants in a multiplex manner using nanopore-based sequencing. In some embodiments, the systems and methods may be used to screen different nanopore variants, or different combinations of both nanopore variants and enzyme variants.
    Type: Application
    Filed: February 21, 2020
    Publication date: September 10, 2020
    Inventors: Aruna AYER, George M. CHURCH, Mirko PALLA, Francios PEPIN, Sukanya Srinivasa Rao Arun PUNTHAMBAKER, Peter B. STRANGES