Abstract: A detachable cooling apparatus comprises: a distal miming catheter forming a distal lumen that provides liquid as an input and a proximal miming catheter forming a proximal lumen that receives the liquid as an output, where the proximal miming catheter is connected to the distal running catheter. A focal hypothermia-inducing fluidics system comprises a thermal management and flow system (TMFS) that is operable to alter a liquid to a specific temperature and to regulate a flow rate, a closed-circuit flow system with a detachable cooling apparatus, a distal sensor array, a pump for moving the liquid through the TMFS, an inflow port that receives the liquid from the proximal running catheter, a plurality of capillary tubes that cool the liquid, and an outflow port that returns the liquid to the distal miming catheter.

Abstract: A detachable tip sheathed balloon microcatheter is provided for delivering an embolic agent to a target location for the embolization of an arteriovenous malformation (AVM). The detachable tip sheathed balloon microcatheter including a balloon microcatheter including a first shaft and an inflatable balloon that is coupled to a distal end portion of the first shaft; and a detachable tip assembly that is configured to be detachably coupled to the first shaft of the balloon microcatheter. The detachable tip assembly includes a protective balloon sheath that is coupled to a proximal end portion of the second shaft, wherein when the detachable tip assembly is coupled to the balloon microcatheter, the protective balloon sheath surrounds at least a portion of the inflatable balloon.

Abstract: An improved tissue engineering bioreactor and testing platform has been designed that integrates multiple testing and stimulation capabilities. The system allows for growth of multiple tissue strips in parallel with mechanical and electrical stimulation, media perfusion, and the automated monitoring of contractile force and extracellular electrical activity. The system is designed to be low-cost and scalable, to provide for high-content, biofidelic, non-destructive testing of engineered muscle tissue performance that is conventionally measured using muscle-bath systems.

Abstract: An improved tissue engineering bioreactor and testing platform has been designed that integrates multiple testing and stimulation capabilities. The system allows for growth of multiple tissue strips in parallel with mechanical and electrical stimulation, media perfusion, and the automated monitoring of contractile force and extracellular electrical activity. The system is designed to be low-cost and scalable, to provide for high-content, biofidelic, non-destructive testing of engineered muscle tissue performance that is conventionally measured using muscle-bath systems.