Abstract: The present invention pertains to an improved mesenchymal stromal cell (MSC) preparation and a method for producing the same. The invention provides a new strategy to isolate MSC from bone marrow mononuclear cells (BM-MNCs) by pooling BM-MNCs of multiple unrelated (third-party) bone marrow donors. The MSC preparation manufactured in accordance with the methodology of the invention is characterized by a stable proliferative capability and an increased immunosuppressive potential when compared to individual donor MSC preparations or a pool of individual MSCs generated from multiple donors. The MSCs prepared according to the invention are particularly useful for medical applications such as the treatment of graft-versus-host disease (GvHD) in recipients with hematopoietic stem cell transplants, patients with autoimmune disorders and as a cell-based therapy in regenerative medicine.

Abstract: The invention is based on the finding that a subjects suffering from a viral infection and which is distinguished by a systemic inflammatory complication such as systemic endotheliitis are in particular indicated for a treatment with mesenchymal stromal cell (MSC) compositions. The invention provides treatments in the context of SARS Cov2 infections, in severely affected subjects receiving mechanical ventilation. Provided are MSC compositions for use in treatments, diagnostic stratification methods, and diagnostic kits for such purposes.

Abstract: The invention pertains to the use of mesenchymal stromal cells (MSC) in the treatment of bone disorders or injuries. The invention provides MSC and preparations of specifically pooled MSC for use in the manufacturing of bone graft material for implanting into or attaching to bones in order to enhance bone regeneration after surgery or injury, or to treat various bone disorders, such as osteonecrosis. The invention provides bone graft material, a method for its production, bone graft implants, and medical methods and uses of the inventive products.

Abstract: The present invention pertains to an improved mesenchymal stromal cell (MSC) preparation and a method for producing the same. The invention provides a new strategy to isolate MSC from bone marrow mononuclear cells (BM-MNCs) by pooling BM-MNCs of multiple unrelated (third-party) bone marrow donors. The MSC preparation manufactured in accordance with the methodology of the invention is characterized by a stable proliferative capability and an increased immunosuppressive potential when compared to individual donor MSC preparations or a pool of individual MSCs generated from multiple donors. The MSCs prepared according to the invention are particularly useful for medical applications such as the treatment of graft-versus-host disease (GvHD) in recipients with hematopoietic stem cell transplants, patients with autoimmune disorders and as a cell-based therapy in regenerative medicine.

Abstract: The present invention pertains to an improved mesenchymal stromal cell (MSC) preparation and a method for producing the same. The invention provides a new strategy to isolate MSC from bone marrow mononuclear cells (BM-MNCs) by pooling BM-MNCs of multiple unrelated (third-party) bone marrow donors. The MSC preparation manufactured in accordance with the methodology of the invention is characterized by a stable proliferative capability and an increased immunosuppressive potential when compared to individual donor MSC preparations or a pool of individual MSCs generated from multiple donors. The MSCs prepared ac- cording to the invention are particularly useful for medical applications such as the treatment of graft-versus-host disease (GvHD) in recipients with hematopoietic stem cell transplants, patients with autoimmune disorders and as a cell-based therapy in regenerative medicine.

Abstract: The present invention pertains to an improved mesenchymal stromal cell (MSC) preparation and a method for producing the same. The invention provides a new strategy to isolate MSC from bone marrow mononuclear cells (BM-MNCs) by pooling BM-MNCs of multiple unrelated (third-party) bone marrow donors. The MSC preparation manufactured in accordance with the methodology of the invention is characterized by a stable proliferative capability and an increased immunosuppressive potential when compared to individual donor MSC preparations or a pool of individual MSCs generated from multiple donors. The MSCs prepared ac- cording to the invention are particularly useful for medical applications such as the treatment of graft-versus-host disesase (GvHD) in recipients with hematopoietic stem cell transplants, patients with autoimmune disorders and as a cell-based therapy in regenerative medicine.

Abstract: There are provided measures for a failover functionality for a client-related security association. Such measures exemplarily comprise providing a failover functionality at a proxy function and/or facilitating provision of a failover functionality at a servicing call state control function, wherein the respective failover functionality relates to a first proxy function, the serving function is for servicing the first proxy function and a second proxy function, the first proxy function has a security association with a client, and the first proxy function and the second proxy function are reachable with the same network address.

Abstract: There are provided measures for a failover functionality for a client-related security association. Such measures exemplarily comprise providing a failover functionality at a proxy function and/or facilitating provision of a failover functionality at a servicing call state control function, wherein the respective failover functionality relates to a first proxy function, the serving function is for servicing the first proxy function and a second proxy function, the first proxy function has a security association with a client, and the first proxy function and the second proxy function are reachable with the same network address.

Abstract: Method for simultaneously determining alleles present in a set of loci from at least one nucleic acid sample comprising the steps: a) providing said at least one sample, b) subjecting said sample to a nucleic acid amplification reaction using a primer pair simultaneously primer pairs specific and optimized for each of the loci of a set of at least three loci selected from the group consisting of D2S1360, D7S1517, D8S1132, D9S1118, D10S2325, D11S554, D12S1064, D12S391, D17S1290, D19S253, MYCLl, P450CYP19 and SE-33, and c) evaluating the length and optionally the relative quantity of amplification products obtained from step b) or from the analysis of one or two of the above loci to determine and/or optionally quantify the alleles present at each of the loci analyzed in the set within said sample.

Abstract: A blade tip cap of a turbine blade is repaired by restoring the tip rail and attaching a strengthening rib across the blade tip cap connecting the concave wall to the convex wall of the tip rail.

Abstract: A blade tip cap of a turbine blade is repaired by restoring the tip rail and attaching a strengthening rib across the blade tip cap connecting the concave wall to the convex wall of the tip rail.

Abstract: A ring for mounting a drive element on a valve using a snap connection is provided with a collar and a plurality of locking elements, which together form a receptacle for a shoulder of the drive element. The locking elements are segments of a sheet metal annulus and extend through slots in the collar to the interior of the ring, and include flanges as tool gripping locations. An O-ring disposed in a slot in the collar radially inwardly biases the locking elements, the leading edges of which are chamfered. The shoulder includes outward projections that are correspondingly chamfered and push the locking elements outward as the drive element is inserted into the ring. As the locking elements recoil, a snap connection is made. The ring may be screwed or snapped onto the valve, and the configuration allows a drive element to be snapped into place using the ring or screwed directly onto the valve using a screw cap, without modifying the drive element.

Abstract: A process for coating substrates which has microcavities comprises coating the substrate surface under a vacuum with a predetermined substance to form a layer of the substance deposited on the surface and in the cavity. Directing subsequent layers onto the substrate with an ion bombardment so as to cause the molecular beams of the coating substance to strike the cavities at divergence angles of not greater than 10.degree..

Abstract: A rotor for a centrifuge comprises a bottom part and a top part. The top part is formed with openings for receiving test tubes in rim engagement. The bottom part has an upwardly deformed outer rim, which constitutes a collecting trough. The test tubes are particularly indirectly inserted into the openings (3 to 5) and are biased by spring means (21), which engage the particularly indirectly inserted test tubes from the inside and urges them outwardly against a frustoconical wall (10) of the top part. For an indirect insertion of the test tubes, they may be inserted into guide inserts (6, 7) which consist of cylindrical bushings and are urged outwardly.

Abstract: An apparatus for applying a liquid to a surface comprising an applicator and a body member. The applicator is secured to an end of the body member, the body member defining a reservoir for housing a fluid. The body member includes a piston member for exerting a force on the fluid in the reservoir, and two channels, a first channel being in fluid communication with a channel in the applicator and a second channel being in fluid communication with an area outside the body member. The body member further including a valve for allowing fluid communication between the reservoir and either the first channel or second channel. An additional one-way valve which can be manually deactivated may be included in the second channel.