Abstract: In some aspects, the present invention provides methods and compositions for modifying target sites within nucleic acid molecules. In some embodiments, the methods comprise using adenosine deaminases that act on RNA (ADARs), and variants thereof, to modify target sites within DNA-RNA hybrid molecules. In other aspects, ADAR2 variant polypeptides as well as fusion proteins comprising an ADAR catalytic domain and a hybrid nucleic acid binding domain are provided, as are methods for use thereof. Methods for preventing and treating genetic disorders are also provided herein.

Abstract: Methods, apparatus, and processor-readable storage media for machine learning-based anomaly detection using time series decomposition are provided herein. An example computer-implemented method includes processing, via machine learning techniques pertaining to time series decomposition functions, a first set of historical time series data derived from multiple systems within an enterprise; generating, based on the processed data, one or more pairs of upper bounds and lower bounds directed to system metrics; identifying system anomalies attributed to one or more of the multiple systems within the enterprise by comparing a second set of historical time series data derived from the one or more systems against the one or more pairs of upper bounds and lower bounds; prioritizing, via machine learning techniques pertaining to weighting functions, the system anomalies; and outputting, in accordance with the prioritization, the system anomalies to a user within the enterprise.

Abstract: Methods, apparatus, and processor-readable storage media for determining similarity between time series using machine learning techniques are provided herein. An example computer-implemented method includes obtaining a primary time series and a set of multiple candidate time series; calculating, using machine learning techniques, similarity measurements between the primary time series and each of the candidate time series; for each of the similarity measurements, assigning weights to the candidate time series based on similarity to the primary time series relative to the other candidate time series; generating, for each of the candidate time series, a similarity score based on the weights assigned to each of the candidate time series across the similarity measurements; and outputting, based on the similarity scores, identification of at least one candidate time series for use in one or more automated actions relating to at least one system.

Abstract: Recommending configuration changes may include: receiving a decision tree comprising levels of nodes, wherein the decision tree includes leaf nodes each representing a different one of a plurality of hardware configurations, wherein a first leaf represents a first hardware configuration and the first leaf node is associated with a set of I/O workload features denoting a I/O workload of a first system having the first hardware configuration, wherein the set of I/O workload features is associated with an action from the first leaf node to a second leaf node, wherein the second leaf node represents a second hardware configuration and the action represents a hardware configuration change made to transition from the first to the second hardware configuration; and performing processing that determines, using the decision tree, a recommendation for a hardware configuration change for a second system having the first hardware configuration represented by the first leaf node.

Abstract: In some aspects, the present invention provides methods and compositions for modifying target sites within nucleic acid molecules. In some embodiments, the methods comprise using adenosine deaminases that act on RNA (ADARs), and variants thereof, to modify target sites within DNA-RNA hybrid molecules. In other aspects, ADAR2 variant polypeptides as well as fusion proteins comprising an ADAR catalytic domain and a hybrid nucleic acid binding domain are provided, as are methods for use thereof. Methods for preventing and treating genetic disorders are also provided herein.

Abstract: The invention relates to single-stranded RNA editing antisense oligonucleotides (AO Ns) for binding to a target RNA molecule for deaminating at least one target adenosine present in the target RNA molecule and recruiting, in a cell, preferably a human cell, an ADAR2 enzyme, to deaminate the at least one target adenosine in the target RNA molecule. The AON according to the invention comprises a cytidine analog at the position opposite the target adenosine, wherein the cytidine analog serves as an H-bond donor at the N3 site, for more efficient RNA editing.

Abstract: An apparatus comprises a processing device configured to obtain performance data for a plurality of workloads, to select a subset of the performance data corresponding to a subset of the plurality of workloads having a given workload type, and to generate a model characterizing an expected performance of the given workload type by analyzing the selected subset of the performance data to estimate a queuing curve characterizing the expected performance of the given workload type. The processing device is also configured, responsive to determining that a quality of the generated model is above a designated threshold quality level, to utilize the generated model to identify performance impacting events for a given workload of the given workload type and to modify provisioning of compute, storage and network resources allocated to the given workload responsive to identifying performance impacting events for the given workload of the given workload type.

Abstract: In some aspects, the present invention provides methods and compositions for modifying target sites within nucleic acid molecules. In some embodiments, the methods comprise using adenosine deaminases that act on RNA (ADARs), and variants thereof, to modify target sites within DNA-RNA hybrid molecules. In other aspects, ADAR2 variant polypeptides as well as fusion proteins comprising an ADAR catalytic domain and a hybrid nucleic acid binding domain are provided, as are methods for use thereof. Methods for preventing and treating genetic disorders are also provided herein.

Abstract: A method includes obtaining, in a given log processing node, at least two different types of logs associated with assets of an enterprise system. The method also includes generating, at the given log processing node, frequency scores for terms in unstructured log data of each of the different log types, the generated frequency score for a given term in unstructured log data of a given log type being based on (i) occurrence of the given term in historical logs of the given log type previously processed by log processing nodes and (ii) occurrence of the given term in the obtained logs of the given log type. The method further includes extracting, at the given log processing node, features from the obtained logs based on the frequency scores, detecting events affecting the assets utilizing the extracted features, and modifying a configuration of the assets responsive to detecting the events.

Abstract: Methods, apparatus, and processor-readable storage media for automated stateful counter aggregation of device data are provided herein. An example computer-implemented method includes obtaining historical aggregate counter data and historical individual member counter data associated with a variable set of device members and a given temporal period; computing one or more stateful aggregate counter data values attributed to at least a portion of the variable set of device members for a given temporal value by applying at least one stateful counter aggregation algorithm to the obtained data; and performing one or more automated actions based at least in part on the one or more computed stateful aggregate counter data values.

Abstract: Recommending configuration changes may include: receiving a decision tree comprising levels of nodes, wherein the decision tree includes leaf nodes each representing a different one of a plurality of hardware configurations, wherein a first leaf represents a first hardware configuration and the first leaf node is associated with a set of I/O workload features denoting a I/O workload of a first system having the first hardware configuration, wherein the set of I/O workload features is associated with an action from the first leaf node to a second leaf node, wherein the second leaf node represents a second hardware configuration and the action represents a hardware configuration change made to transition from the first to the second hardware configuration; and performing processing that determines, using the decision tree, a recommendation for a hardware configuration change for a second system having the first hardware configuration represented by the first leaf node.

Abstract: Methods, apparatus, and processor-readable storage media for automatic identification of workloads contributing to behavioral changes in storage systems using machine learning techniques are provided herein. An example computer-implemented method includes obtaining a primary time series and a set of candidate time series; calculating, using machine learning techniques, similarity measurements between the primary time series and each candidate time series in the set; for each similarity measurement, assigning weights to the candidate time series based on similarity values; generating, for each candidate time series, a similarity score based on the assigned weights; automatically identifying, based on the similarity scores, a candidate time series as contributing to an anomaly exhibited in the primary time series; and outputting identifying information of the at least one identified candidate time series for use in one or more automated actions associated with the storage system.

Abstract: Methods, apparatus, and processor-readable storage media for automatic identification of resources in contention in storage systems using machine learning techniques are provided herein.

Abstract: Methods, apparatus, and processor-readable storage media for automated stateful counter aggregation of device data are provided herein. An example computer-implemented method includes obtaining historical aggregate counter data and historical individual member counter data associated with a variable set of device members and a given temporal period; computing one or more stateful aggregate counter data values attributed to at least a portion of the variable set of device members for a given temporal value by applying at least one stateful counter aggregation algorithm to the obtained data; and performing one or more automated actions based at least in part on the one or more computed stateful aggregate counter data values.

Abstract: Methods, apparatus, and processor-readable storage media for automatic identification of workloads contributing to system performance degradation are provided herein. An example computer-implemented method includes obtaining, in connection with a system exhibiting performance degradation, a primary time series and a set of multiple candidate time series; calculating, using machine learning, similarity measurements between the primary time series and each time series in the set; for each measurement, assigning weights to the time series based on similarity to the primary time series relative to the other time series in the set; generating, for each time series in the set, a similarity score based on the weights assigned across the similarity measurements; and outputting, based on the similarity scores, identification of a candidate time series for use in automated actions.

Abstract: A technique manages data storage equipment. The technique involves receiving queue depth metrics from data storage performance data describing data storage performance of the data storage equipment. The technique further involves performing a performance impact detection operation on the queue depth metrics to determine whether a performance impacting event has occurred on the data storage equipment. The technique further involves, in response to a result of the performance impact detection operation indicating that a performance impacting event has occurred on the data storage equipment, launching a set of performance impact operations to address the performance impacting event that occurred on the data storage equipment. Such a technique may be performed by an electronic apparatus coupled with the data storage equipment (e.g., over a network).

Abstract: Methods, apparatus, and processor-readable storage media for automatic identification of workloads contributing to system performance degradation are provided herein. An example computer-implemented method includes obtaining, in connection with a system exhibiting performance degradation, a primary time series and a set of multiple candidate time series; calculating, using machine learning, similarity measurements between the primary time series and each time series in the set; for each measurement, assigning weights to the time series based on similarity to the primary time series relative to the other time series in the set; generating, for each time series in the set, a similarity score based on the weights assigned across the similarity measurements; and outputting, based on the similarity scores, identification of a candidate time series for use in automated actions.

Abstract: Methods, apparatus, and processor-readable storage media for automatic identification of resources in contention in storage systems using machine learning techniques are provided herein.

Abstract: Methods, apparatus, and processor-readable storage media for determining similarity between time series using machine learning techniques are provided herein. An example computer-implemented method includes obtaining a primary time series and a set of multiple candidate time series; calculating, using machine learning techniques, similarity measurements between the primary time series and each of the candidate time series; for each of the similarity measurements, assigning weights to the candidate time series based on similarity to the primary time series relative to the other candidate time series; generating, for each of the candidate time series, a similarity score based on the weights assigned to each of the candidate time series across the similarity measurements; and outputting, based on the similarity scores, identification of at least one candidate time series for use in one or more automated actions relating to at least one system.

Abstract: Methods, apparatus, and processor-readable storage media for automatic identification of workloads contributing to behavioral changes in storage systems using machine learning techniques are provided herein. An example computer-implemented method includes obtaining a primary time series and a set of candidate time series; calculating, using machine learning techniques, similarity measurements between the primary time series and each candidate time series in the set; for each similarity measurement, assigning weights to the candidate time series based on similarity values; generating, for each candidate time series, a similarity score based on the assigned weights; automatically identifying, based on the similarity scores, a candidate time series as contributing to an anomaly exhibited in the primary time series; and outputting identifying information of the at least one identified candidate time series for use in one or more automated actions associated with the storage system.