Abstract: The present invention relates to anti-VEGF/anti-IL-1beta antibodies and methods of using the same.

Abstract: The apparatus and methods disclosed herein relate to diagnosis of disease through the detection of signals from portions of a body. The signals may be acoustic signals, which can be used to diagnose the presence, severity and/or location of occlusions in arteries, such as the coronary arteries. The signals may be detected through noninvasive methods such as, for example, passive reception. Such methods can avoid many of the problems associated with invasive angiogram and angioplasty procedures. The apparatus and methods described herein are not limited to use for diagnosing occlusions in the coronary arteries, but can be used for a wide variety of biomedical diagnosis in human and nonhuman animals.

Abstract: The apparatus and methods disclosed herein relate to diagnosis of disease through the detection of signals from portions of a body. The signals may be acoustic signals, which can be used to diagnose the presence, severity and/or location of occlusions in arteries, such as the coronary arteries. The signals may be detected through noninvasive methods such as, for example, passive reception. Such methods can avoid many of the problems associated with invasive angiogram and angioplasty procedures. The apparatus and methods described herein are not limited to use for diagnosing occlusions in the coronary arteries, but can be used for a wide variety of biomedical diagnosis in human and nonhuman animals.

Abstract: A non-invasive diagnostic tool and method for detecting an obstruction in a coronary artery, the diagnostic tool including a signal processor adapted to receive signals corresponding to a heart beat from a plurality of acoustic sensors attached to the chest of a patient. The signal processor is programmed to identify a diastolic portion of the signals for a plurality of heartbeats and conduct a wavelet transform analysis on the diastolic signals for determining the existence of, as well as the severity and the location of, an obstruction in a coronary artery of the patient.

Abstract: The apparatus and methods disclosed herein relate to diagnosis of disease through the detection of signals from portions of a body. The signals may be acoustic signals, which can be used to diagnose the presence, severity and/or location of occlusions in arteries, such as the coronary arteries. The signals may be detected through noninvasive methods such as, for example, passive reception. Such methods can avoid many of the problems associated with invasive angiogram and angioplasty procedures. The apparatus and methods described herein are not limited to use for diagnosing occlusions in the coronary arteries, but can be used for a wide variety of biomedical diagnosis in human and nonhuman animals.

Abstract: Disclosed are devices, systems, and methods for capturing acoustic data in an efficient manner. Some embodiments have piezoelectric sensing portions with polarization axes and conducting layers. In some embodiments, piezoelectric sensing portions can be positioned generally coplanar to each other and in partial electrical contact. In some embodiments, polarization axes of two piezoelectric sensing portions have a non-zero angle between them. Certain embodiments comprise a noise reducing element. In some embodiments, an electrode is included to detect electrical signals.

Abstract: Disclosed are devices, systems, and methods for capturing acoustic data in an efficient manner. Some embodiments have piezoelectric sensing portions with polarization axes and conducting layers. In some embodiments, piezoelectric sensing portions can be positioned generally coplanar to each other and in partial electrical contact. In some embodiments, polarization axes of two piezoelectric sensing portions have a non-zero angle between them.

Abstract: Disclosed are devices, systems, and methods for capturing acoustic data in an efficient manner. Some embodiments have piezoelectric sensing portions with polarization axes and conducting layers. In some embodiments, piezoelectric sensing portions can be positioned generally coplanar to each other and in partial electrical contact. In some embodiments, polarization axes of two piezoelectric sensing portions have a non-zero angle between them.

Abstract: The invention relates to multiple layer films, comprising at least one outer seal layer, a <10 &mgr;m thick barrier layer consisting of a partially crystalline polyamide mixture of a xylylenediamino adipate and an aliphatic polyamide containing solid, nanoscale fillers as nucleation agents, which for the number-weighted average of all of the dispersed fillers have an extension of ≦10 nm for at least one dimension and an extension of at least 100 nm for another dimension 100 nm; and a plastic support layer, with the exception of a corresponding polyamide layer.