Abstract: The invention relates to novel bispecific antigen binding molecules, comprising at least two antigen binding domains capable of specific binding to OX40 and a particular antigen binding domain capable of specific binding to Fibroblast Activation Protein (FAP), and to methods of producing these molecules and to methods of using the same.

Abstract: A production cell includes: at least one robot arranged to handle products; at least one buffer area for intermediate storage of products inside the production cell; a vision system with cameras arranged to determine, based on images from the cameras, the identity and the location of objects in the production cell a plurality of production modules, each production module comprising at least one Hardware Module configured to process products; and a plurality of module attachment locations, each module attachment location being configured to connect with an interface section of a production module through at least a physical connection and a power connection.

Abstract: A method for calibrating a multiplicity of cameras on a vehicle in a common coordinate system. The method includes: a) acquiring camera images using each camera of the multiplicity of cameras, b) ascertaining overlap regions of camera images acquired in step a), c) setting up a common optimization function, which describes the alignments of each camera of the multiplicity of cameras as a target variable of the optimization, based on the overlap regions, d) solving the common optimization function set up in step c) to ascertain the alignments of each camera.

Abstract: A method and a control device determine a position-related braking ability of a vehicle. A first vehicle determines at least one piece of position-related information of a route section, the at least one piece of position-related information of the route section being information relating to the braking ability on the route section. The first vehicle transmits the at least one piece of position-related information to a receiver, the receiver being at least one second vehicle, whereby the braking curves of at least one rail vehicle are adapted according to the situation, thus allowing safety on the route section and the utilization of the section to be improved.

Abstract: A method and device supply a vehicle with main and auxiliary air, wherein the device includes a compressor driven via an electric motor for generating compressed air to fill at least one main air tank for supplying pneumatic units of the vehicle, wherein the vehicle has at least one first and second power source for supplying electric energy, wherein a pneumatic actuator that upgrades the vehicle and activates the first power source is provided with the compressed air produced by the compressor in that, in that phase, the second power source feeds the electric motor of the compressor, wherein a switching valve device supplies the compressed air for upgrading to an auxiliary air tank associated with the pneumatic actuator, and otherwise the switching valve device supplies the compressed air produced by the to the main air tank.

Abstract: A method and a control device determine a position-related braking ability of a vehicle. A first vehicle determines at least one piece of position-related information of a route section, the at least one piece of position-related information of the route section being information relating to the braking ability on the route section. The first vehicle transmits the at least one piece of position-related information to a receiver, the receiver being at least one second vehicle, whereby the braking curves of at least one rail vehicle are adapted according to the situation, thus allowing safety on the route section and the utilization of the section to be improved.

Abstract: A messaging system in one embodiment includes a messaging app and a polling extension app. The polling extension app is configured to create data for a polling context that is displayed in a view hosted by the messaging app to allow voting by users selected for the poll and to update the polling context with the votes from the users. The messaging app launches the polling extension app, and the polling context is communicated between the polling extension app and the messaging app through an interprocess communication.

Abstract: A method and device control at least one air dryer unit of an air supply system for the primary and auxiliary air supply of a vehicle. In the method and device, at least one compressor is driven by an associated electric motor that serves both for the primary air supply of a primary air tank and for the auxiliary air supply of an auxiliary air tank. Compressed air generated by the compressor is channeled over the at least one downstream air dryer unit so as to dry the compressed air generated by the compressor while the drying agent of the air dryer is regenerated with dried compressed air. During the auxiliary air supply, the air flow used for regenerating the at least one air dryer unit is reduced or suppressed.

Abstract: A method and device supply a vehicle with main and auxiliary air, wherein the device includes a compressor driven via an electric motor for generating compressed air to fill at least one main air tank for supplying pneumatic units of the vehicle, wherein the vehicle has at least one first and second power source for supplying electric energy, wherein a pneumatic actuator that upgrades the vehicle and activates the first power source is provided with the compressed air produced by the compressor in that, in that phase, the second power source feeds the electric motor of the compressor, wherein a switching valve device supplies the compressed air for upgrading to an auxiliary air tank associated with the pneumatic actuator, and otherwise the switching valve device supplies the compressed air produced by the to the main air tank.

Abstract: A method and device control at least one air dryer unit of an air supply system for the primary and auxiliary air supply of a vehicle. In the method and device, at least one compressor is driven by an associated electric motor that serves both for the primary air supply of a primary air tank and for the auxiliary air supply of an auxiliary air tank. Compressed air generated by the compressor is channeled over the at least one downstream air dryer unit so as to dry the compressed air generated by the compressor while the drying agent of the air dryer is regenerated with dried compressed air. During the auxiliary air supply, the air flow used for regenerating the at least one air dryer unit is reduced or suppressed.

Abstract: A messaging system in one embodiment includes a messaging app and a polling extension app. The polling extension app is configured to create data for a polling context that is displayed in a view hosted by the messaging app to allow voting by users selected for the poll and to update the polling context with the votes from the users. The messaging app launches the polling extension app, and the polling context is communicated between the polling extension app and the messaging app through an interprocess communication.

Abstract: In one aspect, the present invention provides methods of determining whether an agent is more like a partial agonist of a target molecule than a full agonist of the same target molecule. In another aspect, the present invention provides methods to select a candidate compound that may reduce blood plasma glucose concentration in a mammal. Populations of genes are provided that are useful in the practice of the present invention.

Abstract: In one aspect, the present invention provides methods of determining whether an agent is more like a partial agonist of a target molecule than a full agonist of the same target molecule. In another aspect, the present invention provides methods to select a candidate compound that may reduce blood plasma glucose concentration in a mammal. Populations of genes are provided that are useful in the practice of the present invention.

Abstract: In one aspect, the present invention provides methods of determining whether an agent is more like a partial agonist of a target molecule than a full agonist of the same target molecule. In another aspect, the present invention provides methods to select a candidate compound that may reduce blood plasma glucose concentration in a mammal. Populations of genes are provided that are useful in the practice of the present invention.

Abstract: Certain embodiments are a method of treating a patient comprising deploying an embolic trap to remove emboli from a vein of the patient while performing an orthopedic procedure on the patient.

Abstract: An apparatus and method for melt spinning polymeric yarns, wherein a main melt flow is generated by an extruder and supplied to a spin head. The spin head is enclosed in a heated spinning beam and comprises a mixer, a distributor pump and a plurality of spinnerets. A feed device generates a secondary flow which is supplied to the main melt flow for the purpose of additive admixture. The secondary flow and the main melt flow are combined inside the spinning beam.

Abstract: A cart for transporting and supporting electronic equipment such as musical instrument amplifiers includes a wheeled open frame which defines an amplifier-receiving space therein. The frame rotatably supports an amplifier support chassis so that the support chassis is pivotable about a pivot axis for varying the angular orientation of a piece of equipment supported on the support chassis. The support chassis includes inner and outer members telescopingly interconnected for adjusting the depth of the support chassis. A fulcrum bar rotatably supported by the frame is affixed to the support chassis for providing the pivotal capability to the support chassis. A locking mechanism is provided for fixing the support chassis in a selected orientation, and a restraint is attached to the frame for encircling and restraining a piece of equipment supported in the cart.

Abstract: A draw process is described, in which yarns in particular of thermoplastic plastics are drawn by influencing their temperature, so as to improve the yarn properties. The process can be employed in a spin process or in a subsequent improvement step. In accordance with the invention, the temperature of the temperature modulating device is controlled as a function of a yarn tension signal, which is obtained within or downstream of the draw zone.

Abstract: A yarn heating apparatus for use in a yarn false twisting machine, which has an axial channel in which the yarn advances along a zigzagged path. To guide the yarn in the axial channel, yarn guides are provided, which are shaped as spaced apart protuberances on two metal strips. The metal strips are supported in contact with the side walls of the axial channel.

Abstract: A method and apparatus for controlling the traversing frequency during the winding of a cross-wound package. In so doing, a signal is detected which is generated by the motion of the yarn while being wound onto a yarn package. Thereafter, the signal is analyzed by frequency, and/or amplitude, or other characteristics. Finally, the traversing frequency of the yarn takeup system is adjusted or varied as a function of the analysis result. In the preferred embodiment, the signal is proportional to a development of airborne sound or a development of solid-borne sound, each of which is generated in response to the motion of the advancing yarn on the package being formed. The method of the present invention allows disturbances in the winding operation to be avoided, such as the formation of so-called ribbons and similar phenomena.