Abstract: The claimed invention is directed to a novel composite half shaft. More specifically, the claimed invention provides for the integration of a continuous velocity joint within the hollow tubular portion of the axle shaft, which permits for a longer lightweight composite hollow shaft. The use of the lightweight material over additional length results in an overall weight reduction. Additional benefits include reduced unsprung weight in vehicles, improved mileage for gas powered vehicles and increased range for electric vehicles. The use of composite materials in place of a solid or hollow metal axle bar results in improved noise, vibration and harshness (“NVH”) characteristics over conventional half shafts..

Abstract: A composite vehicle driveshaft is provided with a composite tube and a welded joint system(s) at one or both ends of the composite tube for connecting the composite vehicle driveshaft to driveline components. Each welded joint system may include a sleeve that is bonded to an end of the composite tube and a joint assembly that is welded to the sleeve.

Abstract: A composite vehicle driveshaft is provided with a crash collapse system that allows for a controlled longitudinal collapse of the driveshaft by facilitating telescopic movement of various components with respect to each other during a crash event. The crash collapse system may include a collapsible joint with a sleeve that is concentrically bonded in an end of a composite tube and a stub end assembly that is spline-engaged and interference fit within the sleeve, such as by way of a press-fit and/or a thermal shrink-fit procedure. This relationship may rotationally lock and axially fix the stub end assembly to the sleeve unless, during a crash event, the composite vehicle driveshaft experiences a compression or push-type force that exceeds a minimum breakaway or collapse force value that longitudinally and telescopically collapses the composite vehicle driveshaft.

Abstract: A composite vehicle driveshaft is provided with a composite tube and a welded joint system(s) at one or both ends of the composite tube for connecting the composite vehicle driveshaft to driveline components. Each welded joint system may include a sleeve that is bonded to an end of the composite tube and a joint assembly that is welded to the sleeve.

Abstract: A composite vehicle driveshaft is provided with a crash collapse system that allows for a controlled longitudinal collapse of the driveshaft by facilitating telescopic movement of various components with respect to each other during a crash event. The crash collapse system may include a collapsible joint with a sleeve that is concentrically bonded in an end of a composite tube and a stub end assembly that is spline-engaged and interference fit within the sleeve, such as by way of a press-fit and/or a thermal shrink-fit procedure. This relationship may rotationally lock and axially fix the stub end assembly to the sleeve unless, during a crash event, the composite vehicle driveshaft experiences a compression or push-type force that exceeds a minimum breakaway or collapse force value that longitudinally and telescopically collapses the composite vehicle driveshaft.

Abstract: A system for dispensing a sample into a buffer liquid includes a pressure chamber having pressure supply means for generating an overpressure within the pressure chamber. An inlet capillary supplies a buffer liquid to an outlet end arranged in the pressure chamber, and an outlet capillary discharges the buffer liquid from the pressure chamber. The outlet capillary has an inlet end in the pressure chamber facing the outlet end of the inlet capillary to form a capillary gap. A dispenser having a dispensing end is in the pressure chamber at the capillary gap to allow the sample at the dispensing end to be dispensed into the buffer liquid entering the outlet capillary inlet end. The pressure chamber includes a sample port that allows the dispenser to be moved into and out of the pressure chamber.

Abstract: A system for dispensing a sample (5) into a buffer liquid comprises a pressure chamber (1) having pressure supply means for generating an overpressure within the pressure chamber. An inlet capillary (2) is provided for supplying a buffer liquid (9) to an outlet end (6) arranged in the pressure chamber. Also, an outlet capillary (3) is provided for discharging buffer liquid and/or sample from the pressure chamber. The outlet capillary (3) has an inlet end (7) arranged in the pressure chamber (1) facing the outlet end (6) of the inlet capillary (2) to form a capillary gap (8). A dispenser (4) having a dispensing end (10) is arranged in the pressure chamber (1) at the capillary gap (8) to allow the sample (5) at the dispensing end (10) to be dispensed from the dispensing end (10) into the buffer liquid entering the inlet end (7) of the outlet capillary (3).

Abstract: The invention generally relates to biomarkers associated with NSCLC, and methods and compositions for the detection and diagnosis of non-small cell lung cancer in a human subject.

Abstract: A sorption micro-array (1) for sorbing a substance off an assay sample comprises a support (11) and a plurality of sorption elements (14). The plurality of sorption elements (14) is arranged in a well defined geometry in connection with the support (11), wherein the distance between each sorption element (14) and its adjacent sorption element (14) is predefined. Since all of the sorption elements (14) are arranged at a well defined location of the sorption micro-array (1), e.g. in a row with well defined distances from each other, the output of an analysis of substances sorbed by each of the sorption elements (14) can exactly be allocated to a well defined location of an assay sample from which the substances have been sorbed. Like this, it is possible to provide an exact chemical output image of the micro-distribution of the substances of the assay sample.

Abstract: A separation device and a separation method for biomolecular sample material and in particular protein mixtures. For this purpose a separation element 10 for the two-dimensional and preferable electrophoretic separation of components of the sample material is provided in area 30 of a separation plane. According to the invention it is proposed that the separation element 10 has a channel or transfer structure 14 for the locally resolved discharge of separated sample components in a transport direction that is at right angles to the separation plane onto a support surface 16 that is preferably suitable for mass spectroscopic analyses.

Abstract: The present invention relates to the diagnosis of breast cancer. It discloses the use of protein cellular retinoic acid binding protein II in the diagnosis of breast cancer. It relates to a method for diagnosis of breast cancer from a liquid sample, derived from an individual by measuring cellular retinoic acid binding protein II in said sample. Measurement of cellular retinoic acid binding protein II can, e.g., be used in the early detection or diagnosis of breast cancer.

Abstract: The present invention relates to the diagnosis of breast cancer. It discloses the use of protein ASC in the diagnosis of breast cancer. It relates to a method for diagnosis of breast cancer from a liquid sample, derived from an individual by measuring ASC in the sample. Measurement of ASC can, e.g., be used in the early detection or diagnosis of breast cancer.

Abstract: A sorption micro-array (1) for sorbing a substance off an assay sample comprises a support (11) and a plurality of sorption elements (14). The plurality of sorption elements (14) is arranged in a well defined geometry in connection with the support (11), wherein the distance between each sorption element (14) and its adjacent sorption element (14) is predefined. Since all of the sorption elements (14) are arranged at a well defined location of the sorption micro-array (1), e.g. in a row with well defined distances from each other, the output of an analysis of substances sorbed by each of the sorption elements (14) can exactly be allocated to a well defined location of an assay sample from which the substances have been sorbed. Like this, it is possible to provide an exact chemical output image of the micro-distribution of the substances of the assay sample.

Abstract: The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein proteasome subunit alpha 3 (PSA3) in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a liquid sample, derived from an individual by measuring PSA3 in said sample. Measurement of PSA3 can, e.g., be used in the early detection or diagnosis of colorectal cancer.

Abstract: The present invention relates to the diagnosis of breast cancer. It discloses the use of protein PDX1 (peroxiredoxin 1) in the diagnosis of breast cancer. It relates to a method for diagnosis of breast cancer from a liquid sample, derived from an individual by measuring PDX1 in said sample. Measurement of PDX1 can, e.g., be used in the early detection or diagnosis of breast cancer.

Abstract: The present invention relates to the diagnosis of colorectal cancer. It discloses the use of the protein nicotinamide N-methyltransferase (NNMT) in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a liquid sample, derived from an individual by measuring NNMT in said sample. Measurement of NNMT can, e.g., be used in the early detection or diagnosis of colorectal cancer.

Abstract: The present invention relates to the diagnosis of breast cancer. It discloses the use of spermidine synthase (SPEE) in the diagnosis of breast cancer. It relates to a method for diagnosis of breast cancer from a liquid sample, derived from an individual by measuring SPEE in the sample. Measurement of SPEE can, e.g., be used in the early detection or diagnosis of breast cancer.

Abstract: The present invention relates to the diagnosis of breast cancer. It discloses the use of ubiquitin-conjugating enzyme E2N (UBC13) in the diagnosis of breast cancer. It relates to a method for diagnosis of breast cancer from a liquid sample, derived from an individual by measuring UBC13 in the sample. Measurement of UBC13 can, e.g., be used in the early detection or diagnosis of breast cancer.

Abstract: The present invention relates to the diagnosis of breast cancer. It discloses the use of protein ASC in the diagnosis of breast cancer. It relates to a method for diagnosis of breast cancer from a liquid sample, derived from an individual by measuring ASC in the sample. Measurement of ASC can, e.g., be used in the early detection or diagnosis of breast cancer.