Patents by Inventor Peter Bertinato

Peter Bertinato has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Selectively substituted quinoline compounds
    Patent number: 9663486
    Abstract: Embodiments of the disclosure relate to selectively substituted quinoline compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.
    Type: Grant
    Filed: October 14, 2014
    Date of Patent: May 30, 2017
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Roch Boivin, Hans Hansen, Sally Ishizaka, Matthew Mackey, Shawn Schiller, Chikako Ogawa, Sridhar Narayan, Peter Bertinato, Gregory Berger, Atsushi Endo, Robert T. Yu, Lynn Hawkins
  • SELECTIVELY SUBSTITUTED QUINOLINE COMPOUNDS
    Publication number: 20160176841
    Abstract: Embodiments of the disclosure relate to selectively substituted quinoline compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.
    Type: Application
    Filed: October 14, 2014
    Publication date: June 23, 2016
    Applicant: EISAI R&D MANAGEMENT CO., LTD.
    Inventors: Roch BOIVIN, Hans HANSEN, Sally ISHIZAKA, Matthew MACKEY, Shawn SCHILLER, Chikako OGAWA, Sridhar NARAYAN, Peter BERTINATO, Gregory BERGER, Atsushi ENDO, Robert T. YU, Lynn HAWKINS
  • Synthesis of epothilones, intermediates thereto, analogues and uses thereof
    Patent number: 8481575
    Abstract: The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.
    Type: Grant
    Filed: March 3, 2011
    Date of Patent: July 9, 2013
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Samuel J. Danishefsky, Peter Bertinato, Dai-shi Su, Dongfang Meng, Ting-Chao Chou, Ted Kamenecka, Erik J. Sorensen, Aaron Balog, Kenneth A. Savin
  • TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS
    Publication number: 20110263588
    Abstract: The present invention relates to compounds that may be negative allosteric modulators of metabotropic receptors-subtype 5, and methods of making and using same.
    Type: Application
    Filed: October 23, 2009
    Publication date: October 27, 2011
    Applicant: GLAXO GROUP LIMITED
    Inventors: Peter Bertinato, Merav Fichman, Shomir Ghosh, Jian Lin, Dalia Segal, Zhaoda Zhang
  • SYNTHESIS OF EPOTHILONES, INTERMEDIATES THERETO, ANALOGUES AND USES THEREOF
    Publication number: 20110263663
    Abstract: The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.
    Type: Application
    Filed: March 3, 2011
    Publication date: October 27, 2011
    Applicant: SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH
    Inventors: Samuel J. Danishefsky, Peter Bertinato, Dai-shi Su, Dongfang Meng, Ting-Chao Chou, Ted Kamenecka, Erik J. Sorensen, Aaron Balog, Kenneth A. Savin
  • SYNTHESIS OF EPOTHILONES, INTERMEDIATES THERETO, ANALOGUES AND USES THEREOF
    Publication number: 20100240721
    Abstract: The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.
    Type: Application
    Filed: May 28, 2010
    Publication date: September 23, 2010
    Inventors: Samuel J. Danishefsky, Peter Bertinato, Dai-shi Su, Dongfang Meng, Ting-Chao Chou, Ted Kamenecka, Erik J. Sorensen, Aaron Balog, Kenneth A. Savin
  • Synthesis of epothilones, intermediates thereto, analogues and uses thereof
    Patent number: 7750164
    Abstract: The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.
    Type: Grant
    Filed: January 11, 2007
    Date of Patent: July 6, 2010
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Samuel J. Danishefsky, Peter Bertinato, Dai-Shi Su, Dang Fang Meng, Ting-Chao Chou, Ted Kamenecka, Erik J Sorensen, Aaron Balog, Kenneth A. Savin
  • Triamide-substituted heterobicyclic compounds
    Patent number: 7482368
    Abstract: The invention relates to triamide MTP/ApoB inhibitors of the formula 1 wherein R1-R8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for preparing the compounds. The compounds of the invention are useful for the treatment of obesity and lipid disorders.
    Type: Grant
    Filed: August 2, 2005
    Date of Patent: January 27, 2009
    Assignee: Pfizer Inc
    Inventors: Peter Bertinato, Brian Bronk, Alan E. Blize, Hengmiao Cheng, Jin Li, Hiep Huatan, Clive Mason
  • Substituted quinoline compounds
    Patent number: 7468378
    Abstract: This invention relates to MTP/Apo-B secretion inhibitors of Formula (I) wherein R1—R7, X1, m and n are as defined in the specification, as well as pharmaceutical compositions comprising the compounds, and methods of use of the compounds and compositions. The compounds of the invention are useful in treating obesity and associated diseases, conditions or disorders.
    Type: Grant
    Filed: February 3, 2005
    Date of Patent: December 23, 2008
    Assignee: Pfizer Inc.
    Inventors: Peter Bertinato, Michel A. Couturier, Ernest S. Hamanaka, Marcus D. Ewing, Ralph P. Robinson, Derek L. Tickner
  • Triamide-substituted heterobicyclic compounds
    Patent number: 7393958
    Abstract: This invention relates to MTP/Apo-B secretion inhibitors of Formula (I) wherein R1-R7, X1, m and n are as defined in the specification, as well as pharmaceutical compositions comprising the compounds, and methods of use of the compounds and compositions. The compounds of the invention are useful in treating obesity and associated diseases, conditions or disorders.
    Type: Grant
    Filed: October 30, 2006
    Date of Patent: July 1, 2008
    Assignee: Pfizer, Inc.
    Inventors: Peter Bertinato, Michel A. Couturier, Ernest S. Hamanaka, Marcus D. Ewing, Ralph P. Robinson, Derek L. Tickner
  • Triamide-substituted heterobicyclic compounds
    Patent number: 7368573
    Abstract: This invention relates to MTP/Apo-B secretion inhibitors of Formula (I) wherein R1-R7, X1, m and n are as defined in the specification, as well as pharmaceutical compositions comprising the compounds, and methods of use of the compounds and compositions. The compounds of the invention are useful in treating obesity and associated diseases, conditions or disorders.
    Type: Grant
    Filed: June 15, 2006
    Date of Patent: May 6, 2008
    Assignee: Pfizer Inc.
    Inventors: Peter Bertinato, Michel A. Couturier, Ernest S. Hamanaka, Marcus D. Ewing, Ralph P. Robinson, Derek L. Tickner
  • Triamide-substituted heterobicyclic compounds
    Patent number: 7348355
    Abstract: The invention relates to triamide MTP/ApoB inhibitors of the formula 1 wherein R1-R8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for preparing the compounds. The compounds of the invention are useful for the treatment of obesity and lipid disorders.
    Type: Grant
    Filed: February 10, 2006
    Date of Patent: March 25, 2008
    Assignee: Pfizer Inc.
    Inventors: Peter Bertinato, Alan E. Blize, Brian Bronk, Hengmiao Cheng, Jin Li, Hiep Huatan, Clive Mason
  • Synthesis of epothilones, intermediates thereto, analogues and uses thereof
    Publication number: 20080004450
    Abstract: The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.
    Type: Application
    Filed: January 11, 2007
    Publication date: January 3, 2008
    Inventors: Samuel Danishefsky, Peter Bertinato, Dai-Shi Su, Dong Meng, Ting-Chao Chou, Ted Kamenecka, Erik Sorensen, Aaron Balog, Kenneth Savin
  • Triamide-substituted heterobicyclic compounds
    Publication number: 20070093525
    Abstract: This invention relates to MTP/Apo-B secretion inhibitors of Formula (I) wherein R1-R7, X1, m and n are as defined in the specification, as well as pharmaceutical compositions comprising the compounds, and methods of use of the compounds and compositions. The compounds of the invention are useful in treating obesity and associated diseases, conditions or disorders.
    Type: Application
    Filed: October 30, 2006
    Publication date: April 26, 2007
    Inventors: Peter Bertinato, Michel Couturier, Ernest Hamanaka, Marcus Ewing, Ralph Robinson, Derek Tickner
  • TRIAMIDE-SUBSTITUTED HETEROBICYCLIC COMPOUNDS
    Publication number: 20060223851
    Abstract: This invention relates to MTP/Apo-B secretion inhibitors of Formula (I) wherein R1-R7, X1, m and n are as defined in the specification, as well as pharmaceutical compositions comprising the compounds, and methods of use of the compounds and compositions. The compounds of the invention are useful in treating obesity and associated diseases, conditions or disorders.
    Type: Application
    Filed: June 15, 2006
    Publication date: October 5, 2006
    Inventors: Peter Bertinato, Michel Couturier, Ernest Hamanaka, Marcus Ewing, Ralph Robinson, Derek Tickner
  • Triamide-substituted heterobicyclic compounds
    Publication number: 20060194772
    Abstract: The invention relates to triamide MTP/ApoB inhibitors of the formula 1 wherein R1-R8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for preparing the compounds. The compounds of the invention are useful for the treatment of obesity and lipid disorders.
    Type: Application
    Filed: February 10, 2006
    Publication date: August 31, 2006
    Inventors: Peter Bertinato, Alan Blize, Brian Bronk, Hengmiao Cheng, Jin Li, Hiep Huatan, Clive Mason
  • Triamide-substituted heterobicyclic compounds
    Publication number: 20050288335
    Abstract: The invention relates to triamide MTP/ApoB inhibitors of the formula 1 wherein R1-R8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for preparing the compounds. The compounds of the invention are useful for the treatment of obesity and lipid disorders.
    Type: Application
    Filed: August 2, 2005
    Publication date: December 29, 2005
    Inventors: Peter Bertinato, Alan Blize, Brian Bronk, Hengmiao Cheng, Jin Li, Hiep Huatan, Clive Mason
  • Triamide-substituted heterobicyclic compounds
    Patent number: 6979692
    Abstract: The invention relates to triamide MTP/ApoB inhibitors of the formula 1 wherein R1-R8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for preparing the compounds. The compounds of the invention are useful for the treatment of obesity and lipid disorders.
    Type: Grant
    Filed: August 13, 2003
    Date of Patent: December 27, 2005
    Assignee: Pfizer Inc.
    Inventors: Peter Bertinato, Alan E. Blize, Brian S. Bronk, Hengmiao Cheng, Jin Li, Hiep Huatan, Clive Mason
  • Synthesis of epothilones, intermediates thereto, analogues and uses thereof
    Patent number: 6972335
    Abstract: The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.
    Type: Grant
    Filed: December 4, 2001
    Date of Patent: December 6, 2005
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Samuel J. Danishefsky, Peter Bertinato, Dai-Shi Su, Dongfang Meng, Ting-Chao Chou, Ted Kamenecka, Erik J Sorensen, Aaron Balog, Kenneth A. Savin
  • Synthesis of epothilones, intermediates thereto, analogues and uses thereof
    Patent number: RE41990
    Abstract: The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.
    Type: Grant
    Filed: January 4, 2007
    Date of Patent: December 7, 2010
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Samuel J. Danishefsky, Peter Bertinato, Dai-Shi Su, Dongfang Meng, Ting-Chao Chou, Ted Kamenecka, Erik J. Sorensen, Aaron Balog, Kenneth A. Savin