Abstract: Disclosed herein a robust approach to monitor cell interactions with its surrounding environment in real-time in a physiologically relevant 3-D microenvironment, holding great promise for enhancing future studies of detecting and monitoring cell processes and responses to instructive cues and therapeutic agents. A microfluidic cell culture system is provided that involves a cell sensor in a 3D culture scaffold and one or more microfluidic channels fluidly connected to the 3D culture matrix. The cell sensor involves a planar nucleic acid nanostructure having a top surface and a bottom surface, a plurality sensor molecule attached to the top surface to detect at least two target molecules, and one or more membrane anchoring moieties attached to the bottom surface.

Abstract: Apparatus for storing data and a method of adapting a duration of a wordline pulse in an apparatus for storing data are provided. Sensor circuitry comprises a calibrated bitcell which is calibrated to use a duration of wordline pulse which matches a longest wordline pulse required by any bitcell in an array of bitcells for a successful write operation to be carried out. The duration of wordline pulse is signalled to wordline pulse circuitry, which generates a wordline pulse for the array of bitcells with this wordline pulse duration. The sensor circuitry is configured to adapt the wordline pulse duration in dependence on current local conditions in which the apparatus operates to compensate for influence of the current local conditions on the longest wordline pulse required by any bitcell in the array of bitcells.

Abstract: Apparatus for storing data and a method of adapting a duration of a wordline pulse in an apparatus for storing data are provided. Sensor circuitry comprises a calibrated bitcell which is calibrated to use a duration of wordline pulse which matches a longest wordline pulse required by any bitcell in an array of bitcells for a successful write operation to be carried out. The duration of wordline pulse is signalled to wordline pulse circuitry, which generates a wordline pulse for the array of bitcells with this wordline pulse duration. The sensor circuitry is configured to adapt the wordline pulse duration in dependence on current local conditions in which the apparatus operates to compensate for influence of the current local conditions on the longest wordline pulse required by any bitcell in the array of bitcells.