Patents by Inventor Peter Blaszkiewicz

Peter Blaszkiewicz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Lithium complexes of N-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane, their production and use
    Patent number: 6894151
    Abstract: The invention relates to crystalline lithium complexes of N-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10 tetraazacyclododecane, their production and the recovery of the salt-free gadolinium complex of N-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10 tetraazacyclododecane from the latter without the use of ion exchangers.
    Type: Grant
    Filed: December 13, 2001
    Date of Patent: May 17, 2005
    Assignee: Shering Aktiengesellschaft
    Inventors: Johannes Platzek, Peter Blaszkiewicz, Orlin Petrov, Holger Hoffmann
  • Lithium complexes of N-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane, their production and use
    Publication number: 20020128472
    Abstract: The invention relates to crystalline lithium complexes of N-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10 tetraazacyclododecane, their production and the recovery of the salt-free gadolinium complex of N-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10 tetraazacyclododecane from the latter without the use of ion exchangers.
    Type: Application
    Filed: December 13, 2001
    Publication date: September 12, 2002
    Applicant: Schering AG
    Inventors: Johannes Platzek, Peter Blaszkiewicz, Orlin Petrov, Holger Hoffmann
  • Process for mono- and 1,7-bis-N-.beta.-hydroxyalkylation of cyclene; N-.beta.-hydroxyalkyl-1,4,7,10-tetraazacyclododecane-lithium-salt complexes and the use of the complexes for the production of gadobutrol and analogs
    Patent number: 5994536
    Abstract: The invention relates to the process for mono- and 1,7-bis-N-.beta.-hydroxyalkylation of cyclene, the corresponding mono- and 1,7-bis-N-.beta.-hydroxyalkyl-1,4,7,10-tetraazacyclododecane-Li-salt complexes as intermediate products in the process and the use of the N-(6-hydroxy-2,3-dimethyl-1,3-dioxepan-5-yl)-1,4,7,10-tetraazacyclododecan e-LiCl complex for the production of gadobutrol [Gd ocmplex of N-(1-hydroxy-methyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10- tetraazacyclododecane].
    Type: Grant
    Filed: June 2, 1998
    Date of Patent: November 30, 1999
    Assignee: Schering Aktiengesellschaft
    Inventors: Orlin Petrov, Peter Blaszkiewicz
  • Nonionic x-ray contrast medium with high iodine content
    Patent number: 5232685
    Abstract: 5-Hydroxyacetamido-2,4,6-triido-isophthalic acid-(2,3-dihydroxy-N-methyl-propyl)-(2-hydroxy-ethyl)-diamide is outstandingly suitable as x-ray contrast medium.
    Type: Grant
    Filed: October 22, 1992
    Date of Patent: August 3, 1993
    Assignee: Schering Aktiengesellschaft
    Inventors: Ulrich Speck, Peter Blaszkiewicz
  • Nonionic x-ray contrast medium with high iodine content
    Patent number: 5183654
    Abstract: 5-Hydroxyacetamido-2,4,6-triido-isophthalic acid-(2,3-dihydroxy-N-methyl-propyl)-(2-hydroxy-ethyl)-diamide is outstandingly suitable as x-ray contrast medium.
    Type: Grant
    Filed: November 2, 1990
    Date of Patent: February 2, 1993
    Assignee: Schering Aktiengesellschaft
    Inventors: Ulrich Speck, Peter Blaszkiewicz
  • Method of using fluorosubstituted benzene derivatives in F-NMR imaging
    Patent number: 5130119
    Abstract: Fluorosubstituted benzene derivatives of Formula I ##STR1## wherein Y, R.sup.2, R.sup.3 and R.sup.4 are defined herein, are NMR diagnostic agents.
    Type: Grant
    Filed: October 6, 1989
    Date of Patent: July 14, 1992
    Assignee: Schering Aktiengesellschaft
    Inventors: Peter Blaszkiewicz, Ulrich Niedballa, Heinz Gries, Hans Bauer, Hanns-Joachim Weinmann
  • Dicarboxylic acid-bis(3,5-dicarbamoyl-2,4,6-triiodoanilides) and x-ray contrast media containing them
    Patent number: 5073362
    Abstract: Dicarboxylic acid bis-(3,5-dicarbomoyl-2,4,6-triiodoanilides) of general formula I ##STR1## wherein the amide radicals --CONR.sup.1 R.sup.2 and --CONR.sup.3 R.sup.4 are different from one another andR.sup.1 is a hydrogen, a lower alkyl radical or R.sup.2,R.sup.2 is a straight-chain or branched-chain monohydroxy or polyhydroxy alkyl radical,R.sup.3 is hydrogen, a lower alkyl radical or R.sup.4,R.sup.4 is a straight-chain or branched-chain monohydroxy or polyhydroxy alkyl radical,R.sup.5 is hydrogen, a lower alkyl radical or a monohydroxy or polyhydroxy alkyl radical,X is a straight-chain or branched-chain alkylene with 1 to 6 carbon atoms, which optionally can be substituted by 1 to 6 hydroxy or alkoxy groups or interrupted by one or more oxygen atoms,possess good pharmacological and physicochemical properties rendering them outstandingly suitable as radiopaque substances in X-ray contrast media for use in all fields of application for X-ray contrast media.
    Type: Grant
    Filed: July 16, 1990
    Date of Patent: December 17, 1991
    Assignee: Schering Aktiengesellschaft
    Inventors: Peter Blaszkiewicz, Ulrich Speck
  • Substituted dicarboxylic acid-bis(3,5-dicarbamoyl-2,4,6-triiodoanilides), process for their production as well as X-ray contrast media containing them
    Patent number: 5004835
    Abstract: The invention relates to new substituted dicarboxylic acid-bis(3,5-dicarbamoyl-2,4,6-triiodoanilines), of general formula I ##STR1## in which R.sup.1 means a hydrogen atom, a C.sub.1 -C.sub.4 alkyl radical or R.sup.2, wherein R.sup.1 and R.sup.2 are the same or different,R.sup.2 means a straight-chain or branched-chain C.sub.2 1.varies.C.sub.8 monohydroxyalkyl radical or polyhydroxyalkyl radical,R.sup.3 means a hydrogen atom, a C.sub.1 -C.sub.4 alkyl radical or R.sup.2,R.sup.4 means a hydrogen atom or a C.sub.1 -C.sub.4 alkyl radical, andn=1 or 2.The new nonionic compounds of formula I because of their good pharmacological and physiocochemical properties are outstandingly suitable as radiopaque substances in X-ray contrast media for use in all the fields of applications of X-ray contrast media.
    Type: Grant
    Filed: November 15, 1988
    Date of Patent: April 2, 1991
    Assignee: Schering Aktiengesellschaft
    Inventors: Peter Blaszkiewicz, Ulrich Speck
  • Novel triiodinated isophthalic acid diamides as nonionic X-ray contrast media
    Patent number: 4364921
    Abstract: New triiodinated isophthalic acid diamides of the formula ##STR1## wherein the amide residues --CO--N.R.sub.1 R.sub.2 and --CO--N.R.sub.3 R.sub.4 are different from each other andR.sub.1 is hydrogen or C.sub.1-6 alkyl,R.sub.2 is mono- or polyhydroxyalkyl,R.sub.3 is hydrogen or C.sub.1-6 alkyl,R.sub.4 is mono- or polyhydroxylalkyl,R.sub.5 is C.sub.1-6 alkyl or mono- or polyhydroxy-C.sub.1-6 -alkyl or C.sub.1-3 -alkoxy-C.sub.1-3 -alkyl, andR.sub.6 is hydrogen, C.sub.1-6 alkyl or mono- or polyhydroxyalkyl provide superior nonionic X-ray contrast media.
    Type: Grant
    Filed: March 6, 1980
    Date of Patent: December 21, 1982
    Assignee: Schering, Aktiengesellschaft
    Inventors: Ulrich Speck, Peter Blaszkiewicz, Dieter Seidelmann, Erich Klieger