Abstract: The present invention relates to the treatment or prevention of disorders where modulation of connexin 26 and/or p38 expression may be beneficial, and to tonabersat or an analogue of formula (I), and compositions comprising tonabersat or an analogue of formula (I) for use in said treatments.

Abstract: The present invention relates to the treatment or prevention of allodynia and/or hyperalgesia, and to tonabersator an analogueof formula (1), and compositions comprising tonabersat or an analogue of formula (1) for use in said treatments.

Abstract: The present invention relates to the treatment or prevention of infectious disorders, and to tonabersat or an analogue of formula (1), and compositions comprising tonabersat or an analogue of formula (1) for use in said treatments.

Abstract: The present invention relates to the treatment of the premonitory symptoms of migraine, to the treatment of aura associated with or without migraine, epilepsy, non-epileptic seizures, stroke or other cardiovascular disorders, to the pre-emptive treatment of aura, migraine, epilepsy, stroke or other cardiovascular disorders, to the treatment of migraine recurrence or aura recurrence, and to tonabersat, co-crystals thereof, and compositions comprising tonabersat for use in said treatments.

Abstract: The present invention provides systems, apparatuses and methods that can manage the distribution of items such as playlists. The present invention also provides for controlling the Digital Rights Management (DRM) of licensed items provided to each remote location without the need for local servers at each remote location. The present invention can also manage the uploading and publishing of items created at a remote location for distribution to other remote locations. Further, the present invention effectively manages creation and presentation of playlists based on the digital access rights of playlist users.