Patents by Inventor Peter Blumbergs

Peter Blumbergs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutical compositions comprising forms of 5-azacytidine
    Patent number: 9192620
    Abstract: The invention provides novel polymorphic and pseudopolymorphic crystalline forms of 5-azacyditine, along with methods for preparing said forms, wherein 5-azacytidine is represented by the formula: The invention also includes pharmaceutical compositions comprising said forms.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: November 24, 2015
    Assignee: Pharmion LLC
    Inventors: Dumitru Ionescu, Peter Blumbergs, Lee Alani Selvey
  • Methods for isolating crystalline form I of 5-azacytidine
    Patent number: 8975392
    Abstract: The invention includes methods for isolating crystalline Form I of 5-azacytidine substantially free of other forms, wherein 5-azacytidine is represented by the formula: The invention also includes pharmaceutical compositions comprising Form I of 5-azacytidine.
    Type: Grant
    Filed: June 7, 2013
    Date of Patent: March 10, 2015
    Assignee: Pharmion LLC
    Inventors: Dumitru Ionescu, Peter Blumbergs, Lee Alani Selvey
  • Pharmaceutical compositions comprising 5-azacytidine monohydrate
    Patent number: 8779117
    Abstract: Provided herein are pharmaceutical compositions or dosage forms comprising crystalline 5-azacytidine monohydrate. The pharmaceutical compositions or dosage forms provided herein may be used for oral administration in the treatment of diseases, including the treatment of myelodysplastic syndromes (MDS).
    Type: Grant
    Filed: May 25, 2010
    Date of Patent: July 15, 2014
    Assignee: Pharmion LLC
    Inventors: Dumitru Ionescu, Peter Blumbergs, Gary L. Silvey
  • PHARMACEUTICAL COMPOSITIONS COMPRISING FORMS OF 5-AZACYTIDINE
    Publication number: 20140107058
    Abstract: The invention provides novel polymorphic and pseudopolymorphic crystalline forms of 5-azacyditine, along with methods for preparing said forms, wherein 5-azacytidine is represented by the formula: The invention also includes pharmaceutical compositions comprising said forms.
    Type: Application
    Filed: December 20, 2013
    Publication date: April 17, 2014
    Applicant: PHARMION LLC
    Inventors: Dumitru IONESCU, Peter BLUMBERGS, Lee Alani SELVEY
  • Pharmaceutical compositions comprising forms of 5-azacytidine
    Patent number: 8614313
    Abstract: The invention provides novel polymorphic and pseudopolymorphic crystalline forms of 5-azacytidine, along with methods for preparing said forms, wherein 5-azacytidine is represented by the formula: The invention also includes pharmaceutical compositions comprising said forms.
    Type: Grant
    Filed: August 16, 2012
    Date of Patent: December 24, 2013
    Assignee: Pharmion LLC
    Inventors: Dumitru Ionescu, Peter Blumbergs, Gary L. Silvey
  • METHODS FOR ISOLATING CRYSTALLINE FORM I OF 5-AZACYTIDINE
    Publication number: 20130274459
    Abstract: The invention includes methods for isolating crystalline Form I of 5-azacytidine substantially free of other forms, wherein 5-azacytidine is represented by the formula: The invention also includes pharmaceutical compositions comprising Form I of 5-azacytidine.
    Type: Application
    Filed: June 7, 2013
    Publication date: October 17, 2013
    Inventors: Dumitru IONESCU, Peter Blumbergs, Gary L. Silvey
  • Pharmaceutical compositions comprising forms of 5-azacytidine
    Patent number: 8513406
    Abstract: The invention provides novel polymorphic and pseudopolymorphic crystalline forms of 5-azacytidine, along with methods for preparing said forms, wherein 5-azacytidine is represented by the formula: The invention also includes pharmaceutical compositions comprising said forms.
    Type: Grant
    Filed: August 16, 2012
    Date of Patent: August 20, 2013
    Assignee: Pharmion LLC
    Inventors: Dumitru Ionescu, Peter Blumbergs, Gary L. Silvey
  • Methods for isolating crystalline form I of 5-azacytidine
    Patent number: 8481715
    Abstract: The invention includes methods for isolating crystalline Form I of 5-azacytidine substantially free of other forms, wherein 5-azacytidine is represented by the formula: The invention also includes pharmaceutical compositions comprising Form I of 5-azacytidine.
    Type: Grant
    Filed: June 5, 2012
    Date of Patent: July 9, 2013
    Assignee: Pharmion LLC
    Inventors: Dumitru Ionescu, Peter Blumbergs, Gary L. Silvey
  • PHARMACEUTICAL COMPOSITIONS COMPRISING FORMS OF 5-AZACYTIDINE
    Publication number: 20130059810
    Abstract: The invention provides novel polymorphic and pseudopolymorphic crystalline forms of 5-azacytidine, along with methods for preparing said forms, wherein 5-azacytidine is represented by the formula: The invention also includes pharmaceutical compositions comprising said forms.
    Type: Application
    Filed: August 16, 2012
    Publication date: March 7, 2013
    Applicant: PHARMION LLC
    Inventors: Dumitru Ionescu, Peter Blumbergs, Gary L. Silvey
  • PHARMACEUTICAL COMPOSITIONS COMPRISING FORMS OF 5-AZACYTIDINE
    Publication number: 20130059809
    Abstract: The invention provides novel polymorphic and pseudopolymorphic crystalline forms of 5-azacytidine, along with methods for preparing said forms, wherein 5-azacytidine is represented by the formula: The invention also includes pharmaceutical compositions comprising said forms.
    Type: Application
    Filed: August 16, 2012
    Publication date: March 7, 2013
    Applicant: PHARMION LLC
    Inventors: Dumitru Ionescu, Peter Blumbergs, Gary L. Silvey
  • METHODS FOR ISOLATING CRYSTALLINE FORM I OF 5-AZACYTIDINE
    Publication number: 20120245342
    Abstract: The invention includes methods for isolating crystalline Form I of 5-azacytidine substantially free of other forms, wherein 5-azacytidine is represented by the formula: The invention also includes pharmaceutical compositions comprising Form I of 5-azacytidine.
    Type: Application
    Filed: June 5, 2012
    Publication date: September 27, 2012
    Applicant: PHARMION LLC
    Inventors: Dumitru Ionescu, Peter Blumbergs, Gary L. Silvey
  • Pharmaceutical compositions comprising crystal forms of 5-azacytidine
    Patent number: 8211862
    Abstract: The invention includes methods for isolating crystalline Form I of 5-azacytidine substantially free of other forms, wherein 5-azacytidine is represented by the formula: The invention also includes pharmaceutical compositions comprising Form I of 5-azacytidine.
    Type: Grant
    Filed: March 22, 2010
    Date of Patent: July 3, 2012
    Assignee: Pharmion LLC
    Inventors: Dumitru Ionescu, Peter Blumbergs, Gary L. Silvey
  • SYNTHESIS OF 5-AZACYTIDINE
    Publication number: 20120029181
    Abstract: The present invention provides a method for the preparation of 5-azacytidine, wherein 5-azacytidine is represented by the structure: The method involves the silylation of 5-azacytosine, followed by the coupling of silylated 5-azacytosine to a protected ?-D-ribofuranose derivative. The coupling reaction is catalyzed by trimethylsilyl trifluoromethanesulfonate (TMS-Triflate).
    Type: Application
    Filed: October 13, 2011
    Publication date: February 2, 2012
    Applicant: Pharmion LLC
    Inventors: Dumitru IONESCU, Peter BLUMBERGS
  • Synthesis of 5-azacytidine
    Patent number: 8058424
    Abstract: The present invention provides a method for the preparation of 5-azacytidine, wherein 5-azacytidine is represented by the structure: The method involves the silylation of 5-azacytosine, followed by the coupling of silylated 5-azacytosine to a protected ?-D-ribofuranose derivative. The coupling reaction is catalyzed by trimethylsilyl trifluoromethanesulfonate (TMS-Triflate).
    Type: Grant
    Filed: December 20, 2010
    Date of Patent: November 15, 2011
    Assignee: Pharmion LLC
    Inventors: Dumitru Ionescu, Peter Blumbergs
  • SYNTHESIS OF 5-AZACYTIDINE
    Publication number: 20110092694
    Abstract: The present invention provides a method for the preparation of 5-azacytidine, wherein 5-azacytidine is represented by the structure: The method involves the silylation of 5-azacytosine, followed by the coupling of silylated 5-azacytosine to a protected ?-D-ribofuranose derivative. The coupling reaction is catalyzed by trimethylsilyl trifluoromethanesulfonate (TMS-Triflate).
    Type: Application
    Filed: December 20, 2010
    Publication date: April 21, 2011
    Inventors: Dumitru Ionescu, Peter Blumbergs
  • Synthesis of 5-azacytidine
    Patent number: 7858774
    Abstract: The present invention provides a method for the preparation of 5-azacytidine, wherein 5-azacytidine is represented by the structure: The method involves the silylation of 5-azacytosine, followed by the coupling of silylated 5-azacytosine to a protected ?-D-ribofuranose derivative. The coupling reaction is catalyzed by trimethylsilyl trifluoromethanesulfonate (TMS-Triflate).
    Type: Grant
    Filed: September 10, 2008
    Date of Patent: December 28, 2010
    Assignee: Pharmion LLC
    Inventors: Dumitru Ionescu, Peter Blumbergs
  • Pharmaceutical Compositions Comprising Forms of 5-Azacytidine
    Publication number: 20100298253
    Abstract: The invention provides novel polymorphic and pseudopolymorphic crystalline forms of 5-azacytidine, along with methods for preparing said forms, wherein 5-azacytidine is represented by the formula: The invention also includes pharmaceutical compositions comprising said forms.
    Type: Application
    Filed: May 25, 2010
    Publication date: November 25, 2010
    Inventors: Dumitru Ionescu, Peter Blumbergs, Gary L. Silvey
  • Pharmaceutical Compositions Comprising Crystal Forms of 5-Azacytidine
    Publication number: 20100292180
    Abstract: The invention includes methods for isolating crystalline Form I of 5-azacytidine substantially free of other forms, wherein 5-azacytidine is represented by the formula: The invention also includes pharmaceutical compositions comprising Form I of 5-azacytidine.
    Type: Application
    Filed: March 22, 2010
    Publication date: November 18, 2010
    Inventors: Dumitru Ionescu, Peter Blumbergs, Gary L. Silvey
  • Forms of 5-azacytidine
    Patent number: 7772199
    Abstract: The invention provides novel polymorphic and pseudopolymorphic crystalline forms of 5-azacytidine, along with methods for preparing said forms, wherein 5-azacytidine is represented by the formula: The invention also includes pharmaceutical compositions comprising said forms.
    Type: Grant
    Filed: July 18, 2006
    Date of Patent: August 10, 2010
    Assignee: Celgene Corporation
    Inventors: Dumitru Ionescu, Peter Blumbergs, Gary L Silvey
  • Methods for isolating crystalline form I of 5-azacytidine
    Patent number: 7700770
    Abstract: The invention includes methods for isolating crystalline Form I of 5-azacytidine substantially free of other forms, wherein 5-azacytidine is represented by the formula: The invention also includes pharmaceutical compositions comprising Form I of 5-azacytidine.
    Type: Grant
    Filed: August 5, 2005
    Date of Patent: April 20, 2010
    Assignee: Celgene Corporation
    Inventors: Dumitru Ionescu, Peter Blumbergs, Gary L Silvey