Abstract: The invention relates to an isolated immunoglobulin heavy chain polypeptide and an isolated immunoglobulin light chain polypeptide that bind to a protein encoded by the interleukin 36 receptor (IL-36R). The invention provides an IL-36R-binding agent that comprises the aforementioned immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide. The invention also provides related vectors, compositions, and methods of using the IL-36R-binding agent to treat a disorder or disease that is responsive to IL-36R inhibition, such as cancer, an infectious disease, or an autoimmune disease.

Abstract: The invention relates to an isolated immunoglobulin heavy chain polypeptide and an isolated immunoglobulin light chain polypeptide that bind to a protein encoded by the Lymphocyte Activation Gene-3 (LAG-3). The invention provides a LAG-3-binding agent that comprises the aforementioned immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide. The invention also provides related vectors, compositions, and methods of using, the LAG-3-binding, agent to treat a disorder or disease that is responsive to LAG-3 inhibition, such as cancer or an infectious disease.

Abstract: In accordance with an embodiment, described herein is a system and method for supporting dynamic security configuration in a multitenant application server environment. Common configuration changes required for partition level security can be made without requiring a server restart, such as for example, adding a new security realm for a partition; deleting an existing realm; changing the configuration on an existing realm; adding or removing a security provider to a realm; or changing the configuration of a security provider. In accordance with an embodiment, also described herein is a system and method for supporting dynamic reconfiguration in a multitenant application server environment. Attributes of partition management components, for example managed beans (MBeans) and child MBeans contained within a partition, can be made dynamic and annotated accordingly, so that a restart of servers is not required for configuration changes to those attributes for a particular partition.

Abstract: The invention relates to an isolated immunoglobulin heavy chain polypeptide and an isolated immunoglobulin light chain polypeptide that bind to a protein encoded by the Lymphocyte Activation Gene-3 (LAG-3). The invention provides a LAG-3-binding agent that comprises the aforementioned immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide. The invention also provides related vectors, compositions, and methods of using the LAG-3-binding agent to treat a disorder or disease that is responsive to LAG-3 inhibition, such as cancer or an infectious disease.

Abstract: In accordance with an embodiment, described herein is a system and method for supporting multi-tenancy in an application server, cloud, on-premise, or other environment, which enables categories of components and configurations to be associated with particular application instances or partitions. Resource group templates define, at a domain level, collections of deployable resources that can be referenced from resource groups. Each resource group is a named, fully-qualified collection of deployable resources that can reference a resource group template. A partition provides an administrative and runtime subdivision of the domain, and contains one or more resource groups. Each resource group can reference a resource group template, to bind deployable resources to partition-specific values, for use by the referencing partition. A tenant of the application server or cloud environment can be associated with a partition, or applications deployed therein, for use by that tenant.

Abstract: The invention relates to a multi-fuel engine comprising a primary fuel supply and at least a secondary fuel supply. The primary and at least secondary fuels are arranged to mix with each other and with air for combustion in one or more cylinders of the engine in use. One or more electronic control units (ECU) are provided to control one or more supply characteristics of the primary and/or at least secondary fuel(s) in use. The engine includes a mass air flow (MAF) sensing means. At least one of the ECUs is arranged to receive one or more signals from the MAF sensing means to control, at least partially, one or more supply characteristics of the primary fuel. In addition, the ECU and/or a further ECU is arranged to receive one or more signals from the MAF sensing means to control, at least partially, one or more supply characteristics of the at least secondary fuel.

Abstract: In accordance with an embodiment, described herein is a system and method for supporting multi-tenancy in an application server, cloud, on-premise, or other environment, which enables categories of components and configurations to be associated with particular application instances or partitions. Resource group templates define, at a domain level, collections of deployable resources that can be referenced from resource groups. Each resource group is a named, fully-qualified collection of deployable resources that can reference a resource group template. A partition provides an administrative and runtime subdivision of the domain, and contains one or more resource groups. Each resource group can reference a resource group template, to bind deployable resources to partition-specific values, for use by the referencing partition. A tenant of the application server or cloud environment can be associated with a partition, or applications deployed therein, for use by that tenant.

Abstract: Calibration of a headset that uses bone conduction to provide audio content to a wearer is presented. A first tone of a plurality of tones that are at different frequencies is presented to the wearer via an air conduction transducer. A corresponding tone having a same frequency as the first tone is also presented to the wearer via a bone conduction (BC) transducer. The corresponding tone is adjusted such that a level of loudness is within a threshold range of a level of loudness of the first tone. An ear-canal sound pressure (ECSP) resulting from the first tone is recorded and a voltage applied to the BC transducer for generating the adjusted corresponding tone. An equalization filter is generated based in part on the ECSP and the voltage, the equalization filter for filtering an audio signal for presentation via the BC transducer.

Abstract: A system and method for supporting configuration of dynamic clusters in an application server environment. The method can begin with providing, at one or more computers, including an application server environment executing thereon, a plurality of deployable resources which can be used within the application server environment, and one or more partitions, wherein each partition provides an administrative and runtime subdivision of the domain, wherein the system can associate one or more partitions with a tenant, for use by the tenant. The method can further provide a dynamic cluster for use by the one or more partitions, the dynamic cluster comprising an initial number of servers running within the dynamic cluster. The method can then receive, at an administration server to receive, a command; and then configure, via an API, the dynamic cluster.

Abstract: The invention relates to an isolated immunoglobulin heavy chain polypeptide and an isolated immunoglobulin light chain polypeptide that bind to a protein encoded by the interleukin 36 receptor (IL-36R). The invention provides an IL-36R-binding agent that comprises the aforementioned immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide. The invention also provides related vectors, compositions, and methods of using the IL-36R-binding agent to treat a disorder or disease that is responsive to IL-36R inhibition, such as cancer, an infectious disease, or an autoimmune disease.

Abstract: In accordance with an embodiment, described herein is a system and method for supporting dynamic security configuration in a multitenant application server environment. Common configuration changes required for partition level security can be made without requiring a server restart, such as for example, adding a new security realm for a partition; deleting an existing realm; changing the configuration on an existing realm; adding or removing a security provider to a realm; or changing the configuration of a security provider. In accordance with an embodiment, also described herein is a system and method for supporting dynamic reconfiguration in a multitenant application server environment. Attributes of partition management components, for example managed beans (MBeans) and child MBeans contained within a partition, can be made dynamic and annotated accordingly, so that a restart of servers is not required for configuration changes to those attributes for a particular partition.

Abstract: The invention relates to a multi-fuel engine comprising a primary fuel supply and at least a secondary fuel supply. The primary and at least secondary fuels are arranged to mix with each other and with air for combustion in one or more cylinders of the engine in use. One or more electronic control units (ECU) are provided to control one or more supply characteristics of the primary and/or at least secondary fuel(s) in use. The engine includes a mass air flow (MAF) sensing means. At least one of the ECUs is arranged to receive one or more signals from the MAF sensing means to control, at least partially, one or more supply characteristics of the primary fuel. In addition, the ECU and/or a further ECU is arranged to receive one or more signals from the MAF sensing means to control, at least partially, one or more supply characteristics of the at least secondary fuel.

Abstract: In accordance with an embodiment, described herein is a system and method for providing security in a multitenant application server environment. In accordance with an embodiment, per-partition security configuration includes: per-partition security realm (including configuration for authentication, authorization, credential mapping, auditing, password validation, certificate validation, and user lockout); SSL configuration, including keys, certificates, and other configuration attributes; and access control for partition and global resources. An administrator can designate one or more partition users as partition administrators, via grant of roles.

Abstract: In accordance with an embodiment, described herein is a system and method for JMX support in an application server environment. An exemplary method can provide, at one or more computers, including an application server environment executing thereon, a plurality of deployable resources which can be used within the application server environment, one or more partitions, a plurality of managed beans, each managed beans being a partition level managed bean or a domain level managed bean, each partition level managed bean originating at an originating partition of the one or more partitions, and a JMX framework comprising an API and a managed bean server. The plurality of managed beans can be registered at the managed bean server, with the partition level managed beans being decorated with an identifier.

Abstract: In accordance with an embodiment, described herein is a system and method for supporting multi-tenancy in an application server, cloud, on-premise, or other environment, which enables categories of components and configurations to be associated with particular application instances or partitions. Resource group templates define, at a domain level, collections of deployable resources that can be referenced from resource groups. Each resource group is a named, fully-qualified collection of deployable resources that can reference a resource group template. A partition provides an administrative and runtime subdivision of the domain, and contains one or more resource groups. Each resource group can reference a resource group template, to bind deployable resources to partition-specific values, for use by the referencing partition. A tenant of the application server or cloud environment can be associated with a partition, or applications deployed therein, for use by that tenant.

Abstract: In accordance with an embodiment, described herein is a system and method for supporting multiple partitions and edit sessions in a multitenant application server environment. In accordance with an embodiment, a first administrator or user can obtain a named edit session for use with a partition, make changes, and then activate those changes. Another administrator or user can create a named edit session in parallel. If there are conflicts between a concurrent change and changes being made by another user, the administrator will receive an error when activating the changes. At that point, the administrator can resolve the conflicts and activate the changes. Upon activation, the changes in the edit session will be applied to a global edit configuration.

Abstract: In accordance with an embodiment, described herein is a system and method for supporting multi-tenancy in an application server, cloud, on-premise, or other environment, which enables categories of components and configurations to be associated with particular application instances or partitions. Resource group templates define, at a domain level, collections of deployable resources that can be referenced from resource groups. Each resource group is a named, fully-qualified collection of deployable resources that can reference a resource group template. A partition provides an administrative and runtime subdivision of the domain, and contains one or more resource groups. Each resource group can reference a resource group template, to bind deployable resources to partition-specific values, for use by the referencing partition. A tenant of the application server or cloud environment can be associated with a partition, or applications deployed therein, for use by that tenant.

Abstract: The invention relates to an isolated immunoglobulin heavy chain polypeptide and an isolated immunoglobulin light chain polypeptide that binds to Nerve Growth Factor (NGF). The invention provides an NGF-binding agent that comprises the aforementioned immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide. The invention also provides vectors, compositions, and methods of using the NGF-binding agent to treat an NGF-mediated disease.

Abstract: In accordance with an embodiment, described herein is a system and method for providing security in a multitenant application server environment. In accordance with an embodiment, per-partition security configuration includes: per-partition security realm (including configuration for authentication, authorization, credential mapping, auditing, password validation, certificate validation, and user lockout); SSL configuration, including keys, certificates, and other configuration attributes; and access control for partition and global resources. An administrator can designate one or more partition users as partition administrators, via grant of roles.

Abstract: In accordance with an embodiment, described herein is a system and method for providing security in a multitenant application server environment. In accordance with an embodiment, per-partition security configuration includes: per-partition security realm (including configuration for authentication, authorization, credential mapping, auditing, password validation, certificate validation, and user lockout); SSL configuration, including keys, certificates, and other configuration attributes; and access control for partition and global resources. An administrator can designate one or more partition users as partition administrators, via grant of roles.