Abstract: In accordance with an embodiment, described herein is a system and method for supporting multiple partitions and edit sessions in a multitenant application server environment. In accordance with an embodiment, a first administrator or user can obtain a named edit session for use with a partition, make changes, and then activate those changes. Another administrator or user can create a named edit session in parallel. If there are conflicts between a concurrent change and changes being made by another user, the administrator will receive an error when activating the changes. At that point, the administrator can resolve the conflicts and activate the changes. Upon activation, the changes in the edit session will be applied to a global edit configuration.

Abstract: In accordance with an embodiment, described herein is a system and method for supporting partitions in a multitenant application server environment. In accordance with an embodiment, an application server administrator (e.g., a WLS administrator) can create or delete partitions; while a partition administrator can administer various aspects of a partition, for example create resource groups, deploy applications to a specific partition, and reference specific realms for a partition. Resource groups can be globally defined at the domain, or can be specific to a partition. Applications can be deployed to a resource group template at the domain level, or to a resource group scoped to a partition or scoped to the domain. The system can optionally associate one or more partitions with a tenant, for use by the tenant.

Abstract: In accordance with an embodiment, described herein is a system and method for providing security in a multitenant application server environment. In accordance with an embodiment, per-partition security configuration includes: per-partition security realm (including configuration for authentication, authorization, credential mapping, auditing, password validation, certificate validation, and user lockout); SSL configuration, including keys, certificates, and other configuration attributes; and access control for partition and global resources. An administrator can designate one or more partition users as partition administrators, via grant of roles.

Abstract: A system and method for supporting configuration of dynamic clusters in an application server environment. The method can begin with providing, at one or more computers, including an application server environment executing thereon, a plurality of deployable resources which can be used within the application server environment, and one or more partitions, wherein each partition provides an administrative and runtime subdivision of the domain, wherein the system can associate one or more partitions with a tenant, for use by the tenant. The method can further provide a dynamic cluster for use by the one or more partitions, the dynamic cluster comprising an initial number of servers running within the dynamic cluster. The method can then receive, at an administration server to receive, a command; and then configure, via an API, the dynamic cluster.

Abstract: In accordance with an embodiment, described herein is a system and method for supporting multi-tenancy in an application server, cloud, on-premise, or other environment, which enables categories of components and configurations to be associated with particular application instances or partitions. Resource group templates define, at a domain level, collections of deployable resources that can be referenced from resource groups. Each resource group is a named, fully-qualified collection of deployable resources that can reference a resource group template. A partition provides an administrative and runtime subdivision of the domain, and contains one or more resource groups. Each resource group can reference a resource group template, to bind deployable resources to partition-specific values, for use by the referencing partition. A tenant of the application server or cloud environment can be associated with a partition, or applications deployed therein, for use by that tenant.

Abstract: The invention relates to an isolated immunoglobulin heavy chain polypeptide and an isolated immunoglobulin light chain polypeptide that binds to Nerve Growth Factor (NGF). The invention provides an NGF-binding agent that comprises the aforementioned immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide. The invention also provides vectors, compositions, and methods of using the NGF-binding agent to treat an NGF-mediated disease.

Abstract: The invention relates to an isolated immunoglobulin heavy chain polypeptide and an isolated immunoglobulin light chain polypeptide that binds to Nerve Growth Factor (NGF). The invention provides an NGF-binding agent that comprises the aforementioned immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide. The invention also provides vectors, compositions, and methods of using the NGF-binding agent to treat an NGF-mediated disease.

Abstract: The disclosure relates to an isolated IL-17-binding agent which comprises an immunoglobulin heavy chain polypeptide comprising SEQ ID NO: 1 and optionally an immunoglobulin light chain polypeptide comprising SEQ ID NO: 23, except that one or more specific of residues of SEQ ID NO: 1 and SEQ ID NO: 23 are replaced with a different residue. The disclosure also provides vectors, compositions, and methods of using the IL-17-binding agent to treat an IL-17-mediated disease.

Abstract: A connection management system can achieve scalability for domain computing among a plurality of domains. Each of the plurality of domains comprises a collection of machines and resources that are administrated as a unit. A connection concentrator can connect, and support communication between, a plurality of processes in a first domain and a plurality of processes in a second domain. The connection concentrator uses one connection to communicate with any one of the plurality of processes in the first domain, and can communicate with each one of the plurality of processes in the second domain.

Abstract: A connection management system can achieve scalability for domain computing among a plurality of domains. Each of the plurality of domains comprises a collection of machines and resources that are administrated as a unit. A connection concentrator can connect, and support communication between, a plurality of processes in a first domain and a plurality of processes in a second domain. The connection concentrator uses one connection to communicate with any one of the plurality of processes in the first domain, and can communicate with each one of the plurality of processes in the second domain.

Abstract: A system and method for concentration and load-balancing of requests in a distributed computing environment. In accordance with an embodiment, a system and a method for reducing the number of connections in an Internet environment using one or a plurality of connection handlers which handle the connection from the client to the server, and a listener which determines which connection handler to use to handle the connection. Whereas prior solutions required a (n×m) number of connections to handle requests, the invention allows there to be only m connections which significantly reduces resource requirements and allows scalability.

Abstract: In one embodiment, watch rules can be created for diagnosis information. The watch rules can be examined against the diagnosis information and if there is a match, a notification can be based upon a predetermined notification type.

Abstract: A system and method for concentration and load-balancing of requests in a distributed computing environment. In accordance with an embodiment, a system and a method for reducing the number of connections in an Internet environment using one or a plurality of connection handlers which handle the connection from the client to the server, and a listener which determines which connection handler to use to handle the connection. Whereas prior solutions required a (n×m) number of connections to handle requests, the invention allows there to be only m connections which significantly reduces resource requirements and allows scalability.

Abstract: A system and a method for reducing the number of Object Request Broker (ORB) connections in an Internet Inter-ORB Protocol (IIOP) or similar distributed computing environment. The system reduces the total number of connections needed between the clients and the servers. Embodiments include an intelligent concentrator process for requests going from within a domain to outside of the domain. The concentrator can allow concentration by ensuring that multiple requests from within the domain use the same actual connection for their requests to an object implementation outside of the domain.

Abstract: In one embodiment, watch rules can be created for diagnosis information. The watch rules can be examined against the diagnosis information and if there is a match, a notification can be based upon a predetermined notification type.

Abstract: The present invention provides methods using erythropoietin to improve the tolerance of anti-viral and anti-tumor chemotherapeutic regimens containing interferon. The invention also described improved methods to treat chronic HCV by adjusting the dose of ribavirin to tailor the active dose of the drug while supporting the hemoglobin levels in the patient with EPO. The present invention also provides anti-viral dosing regimens, particularly for chronic HCV comprising administration of an interferon containing anti-viral medicament, EPO, and a compound that reduces the amount of active tumor necrosis factor in the subject.

Abstract: The invention relates generally to distribute computing environments and specifically to a system and a method for reducing the number of Object Request Broker (ORB) connections in an Internet Inter-ORB Protocol (IIOP) environment. Prior solutions required a n×m number of connections to handle requests. The solution described allows there to be only m connections which significantly reduces resource requirements and allows scalability. Prior solutions did not utilize multiple intelligent master concentrator processes to handle concentrator failure or dynamic scalability.

Abstract: A device for remotely opening the safety latch of a hook characterized by an actuating link attached to the safety latch that is selectively movable between a first position, opening the safety latch, and a second position, closing the safety latch. The device further includes actuator, a transmitter and a receiver. The actuator engages the actuating link and selectively moves the actuating link between the first position and the second position. The transmitter transmits operating commands, inputted by the user, to the receiver. The receiver controls the actuator and causes the actuator to selectively move the actuating link between the first position and the second position in response to operating commands from the transmitter.