Abstract: A method of obtaining high affinity human monoclonal antibodies having a Kd of .ltoreq.2.times.10.sup.-9 molar in SCID mice is provided.

Abstract: A compensator is used with a machine frame having a pair of ends, a first mold half secured to one of the frame ends, a second mold half movable along an axis toward and away from the first mold half, and an actuator braced against the other frame end and having an outer end operatively engageable with the second mold half for pressing the second mold half axially against the first mold half. The compensator has an element secured on the second mold half and another element secured on the actuator outer end together forming a substantially closed chamber. The two elements are displaceable axially and tippable relative to each other. A multiplicity of relatively displaceable and substantially incompressible metal balls fills the chamber.

Abstract: A method of treating or preventing RSV infection by the administration of high affinity human monoclonal antibodies having a Kd of about 2.times.10.sup.-9 to 10.sup.-10 molar is provided.

Abstract: A highly efficient method for generating human antibodies in particular which are specific to be RSV fusion protein which combines in vitro priming of human spleen cells and antigen boosting in SCID mice is taught. This method provides for very high human antibody titers which are predominantly of the IgG isotype which contain antibodies of high specificity and affinity to desired antigens. This method is well suited for generating human monoclonal antibodies for therapeutic and diagnostic applications as well as for rescue of human cells for generation of combinational human antibody gene libraries. Two human monoclonal antibodies, RF-1 and RF-2 which each possess an affinity for RSV F-protein about 2.times.10.sup.-9 to 10.sup.-10 Molar are taught as well as their corresponding amino acid and DNA sequences. These antibodies are to be used therapeutically and prophylactically for treating or preventing RSV infection, as well as for diagnosis of RSV in analytes.

Abstract: After a thermoplastic synthetic resin has been injection molded onto a transfer plate in a thermoplastic injection mold, the transfer plate is shifted into a silicone injection mold maintained at a high temperature and a silicone member is injection molded onto the thermoplastic member. The heat transfer to the thermoplastic body is minimized by, for example, providing insulating material between heated portions of the mold system and other portions thereof and/or by maintaining air gaps from which the silicone is excluded between the thermoplastic member and heated portions of the silicone injection mold.

Abstract: An injection-molding apparatus has a housing, a plate fixed on the housing, a plurality of fixed mold halves on the fixed plate, a plate movable along an axis toward and away from the fixed plate and supported on the housing without tie rods, respective movable mold halves on the movable plate engageable with the fixed mold halves, and an actuator rod passing axially through the fixed plate between the fixed mold halves and having an outer end fixed to the movable plate and an opposite inner end. An actuator fixed to the housing and to the inner rod end displaces the movable mold plate and the movable mold halves axially toward and away from the fixed mold plate and fixed mold halves.

Abstract: An injection-molding assembly has a fixed mold plate carrying a centering ring, a fixed mold half carrying a centering ring snugly interfitted with the fixed-plate centering ring, a movable mold plate carrying a centering ring, and a movable mold half carrying a centering ring snugly interfitted with the movable-plate centering ring. One of the rings is formed of an outer ring part having a substantially circular outer periphery and a substantially circular inner periphery and of an inner ring part having a substantially circular outer periphery and a Substantially circular inner periphery. The outer periphery of one of the ring parts has a center of curvature offset radially from a center of curvature of the respective inner periphery. The annular parts can be angularly displaced and can be clamped relative to each other.

Abstract: A method for producing an article of jewelry having a faux pave diamond look. According to the method, at each location where a faux pave diamond is desired, an upwardly extending cylinder is located. The top circular surface of the cylinder is scored or chiseled, first across a diameter to produce a pair of upwardly and outwardly extending inclined semicircular surfaces. Angled thereto, a second chiseling is provided to produce a plurality of upwardly and outwardly inclined surfaces, extending from the center of the cast cylinder. The top surface of the cast cylinder is then plated with rhodium.

Abstract: The problem of insufficient friction along the wall of a rotating funnel feeding viscous material to an extruder or injection molding machine so that the material sweeps past the conveying screw and prevents the conveying screw from continuously feeding that mass to the outlet of the funnel, is solved by providing pins which project inwardly from the rotating funnel wall and engage in interruptions in the flight of the conveying screw. The funnel wall can also be provided with pockets or grooves.

Abstract: A highly viscous or dough-like material, especially glass fiber-filled polyester, polyamide or polypropylene is fed from a rotating funnel via a feed worm lying along a generatrix of the funnel directly into an extruder or an injection molding cylinder and without passing through an elbow or other jacket. The system is thereby able to operate at reduced pressure with least damage to the fibers and reduced drive energy for the feed worm or screw.

Abstract: A plastifying worm for an extruder or injection-molding system utilizes a worm cylinder and a worm or worm core as outer and inner electrodes to which high-frequency energy is applied for direct high-frequency dielectric heating of a thermoplastic synthetic resin. Between the electrodes is disposed an insulator.