Patents by Inventor Peter Brecht
Peter Brecht has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11659997Abstract: Disclosed are instruments and methods for acquiring co-registered orthogonal fluorescence and photoacoustic volumetric projections of an interrogated object. In an embodiment, an instrument includes a rotary mechanism configured to rotate an interrogated object relative to an array of photoacoustic transducers and an optical detector. An optical excitation unit is configured to irradiate the interrogated object with pulses of light, inducing both fluorescence and photoacoustic responses inside the interrogated object at each of a plurality of rotational positions. The array of photoacoustic transducers includes unfocused elements arranged in a pattern along an axis of rotation, the elements configured to detect photoacoustic signals generated inside the volume of the interrogated object. The optical detector is arranged opposite to the array of photoacoustic transducers with respect to the axis of rotation and is configured to register sources of fluorescence excited inside the interrogated object.Type: GrantFiled: June 10, 2020Date of Patent: May 30, 2023Assignee: Photosound Technologies, Inc.Inventors: Sergey A. Ermilov, Hans-Peter Brecht, Vassili Ivanov
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Publication number: 20210038079Abstract: Disclosed are instruments and methods for acquiring co-registered orthogonal fluorescence and photoacoustic volumetric projections of an interrogated object. In an embodiment, an instrument includes a rotary mechanism configured to rotate an interrogated object relative to an array of photoacoustic transducers and an optical detector. An optical excitation unit is configured to irradiate the interrogated object with pulses of light, inducing both fluorescence and photoacoustic responses inside the interrogated object at each of a plurality of rotational positions. The array of photoacoustic transducers includes unfocused elements arranged in a pattern along an axis of rotation, the elements configured to detect photoacoustic signals generated inside the volume of the interrogated object. The optical detector is arranged opposite to the array of photoacoustic transducers with respect to the axis of rotation and is configured to register sources of fluorescence excited inside the interrogated object.Type: ApplicationFiled: June 10, 2020Publication date: February 11, 2021Applicant: PhotoSound Technologies, Inc.Inventors: Sergey A. Ermilov, Hans-Peter Brecht, Vassili Ivanov
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Patent number: 10709419Abstract: A real-time imaging system that provides ultrasonic imaging and optoacoustic imaging coregistered through application of the same hand-held probe to generate and detect ultrasonic and optoacoustic signals. These signals are digitized, processed and used to reconstruct anatomical maps superimposed with maps of two functional parameters of blood hemoglobin index and blood oxygenation index. The blood hemoglobin index represents blood hemoglobin concentration changes in the areas of diagnostic interest relative to the background blood concentration. The blood oxygenation index represents blood oxygenation changes in the areas of diagnostic interest relative to the background level of blood oxygenation. These coregistered maps can be used to noninvasively differentiate malignant tumors from benign lumps and cysts.Type: GrantFiled: September 27, 2016Date of Patent: July 14, 2020Assignee: SENO MEDICAL INSTRUMENTS, INC.Inventors: Alexander A. Oraevsky, Sergey A. Ermilov, Andre Conjusteau, Peter Brecht, Vyacheslav Nadvoretskiy, Richard Su, Donald G. Herzog, Bryan Clingman, Jason Zalev
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Patent number: 10709333Abstract: Disclosed are instruments and methods for acquiring co-registered orthogonal fluorescence and photoacoustic volumetric projections of an interrogated object. In an embodiment, an instrument includes an imaging tank filled with a liquid coupling medium. An object positioning mechanism is configured to position the interrogated object inside the coupling medium and to rotate the interrogated object. An optical excitation unit that is fixed with respect to the tank is configured to induce both fluorescence and photoacoustic responses inside the interrogated object using the same optical excitation spectrum and the same irradiation pattern at the surface of the interrogated object. An array of unfocused photoacoustic transducers is fixed with respect to the tank, and each element of the array is configured to detect photoacoustic signals generated inside the interrogated object.Type: GrantFiled: July 25, 2016Date of Patent: July 14, 2020Inventors: Sergey A. Ermilov, Hans-Peter Brecht, Vassili Ivanov
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Patent number: 10433732Abstract: An optoacoustic imaging system includes a hand-held imaging probe having a light emitting portion and an array of ultrasonic transducers. The probe includes an acoustic lens having an optically reflective material that operates to avoid image artifacts associated with light interactions with the acoustic lens. The optically reflective material may be a thin, highly optically reflective metallic layer. The acoustic lens may be formed from a material such as silicone rubber filled with titanium dioxide or barium sulfate that allows it to reflect and scatter light from illumination components with substantially no absorption of such light, and yet be optically opaque. The probe may include a housing that provides hypo-echoic encapsulation of the probe. An assembly of the array of ultrasonic transducers may include a hypo-echoic material. The probe may include optical windows, each comprising one or more anti-reflection coated plates with acoustic impedance matching that of tissues to be imaged.Type: GrantFiled: January 22, 2013Date of Patent: October 8, 2019Assignee: SENO MEDICAL INSTRUMENTS, INC.Inventors: Alexander A. Oraevsky, Sergey A. Ermilov, Andre Conjusteau, Peter Brecht, Vyacheslav Nadvoretskiy, Richard Su, Donald G. Herzog, Bryan Clingman, Jason Zalev
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Publication number: 20180020920Abstract: Disclosed are instruments and methods for acquiring co-registered orthogonal fluorescence and photoacoustic volumetric projections of an interrogated object. In an embodiment, an instrument includes an imaging tank filled with a liquid coupling medium. An object positioning mechanism is configured to position the interrogated object inside the coupling medium and to rotate the interrogated object. An optical excitation unit that is fixed with respect to the tank is configured to induce both fluorescence and photoacoustic responses inside the interrogated object using the same optical excitation spectrum and the same irradiation pattern at the surface of the interrogated object. An array of unfocused photoacoustic transducers is fixed with respect to the tank, and each element of the array is configured to detect photoacoustic signals generated inside the interrogated object.Type: ApplicationFiled: July 25, 2016Publication date: January 25, 2018Applicant: PhotoSound Technologies, Inc.Inventors: Sergey A. Ermilov, Hans-Peter Brecht, Vassili Ivanov
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Patent number: 9757092Abstract: A real-time imaging method that provides ultrasonic imaging and optoacoustic imaging coregistered through application of the same hand-held probe to generate and detect ultrasonic and optoacoustic signals. These signals are digitized, processed and used to reconstruct anatomical maps superimposed with maps of two functional parameters of blood hemoglobin index and blood oxygenation index. The blood hemoglobin index represents blood hemoglobin concentration changes in the areas of diagnostic interest relative to the background blood concentration. The blood oxygenation index represents blood oxygenation changes in the areas of diagnostic interest relative to the background level of blood oxygenation. These coregistered maps can be used to noninvasively differentiate malignant tumors from benign lumps and cysts.Type: GrantFiled: November 2, 2012Date of Patent: September 12, 2017Assignee: Seno Medical Instruments, Inc.Inventors: Alexander A. Oraevsky, Sergey A. Ermilov, Andre Conjusteau, Peter Brecht, Vyacheslav Nadvoretskiy, Richard Su, Donald G. Herzog, Bryan Clingman, Jason Zalev
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Publication number: 20170014101Abstract: A real-time imaging system that provides ultrasonic imaging and optoacoustic imaging coregistered through application of the same hand-held probe to generate and detect ultrasonic and optoacoustic signals. These signals are digitized, processed and used to reconstruct anatomical maps superimposed with maps of two functional parameters of blood hemoglobin index and blood oxygenation index. The blood hemoglobin index represents blood hemoglobin concentration changes in the areas of diagnostic interest relative to the background blood concentration. The blood oxygenation index represents blood oxygenation changes in the areas of diagnostic interest relative to the background level of blood oxygenation. These coregistered maps can be used to noninvasively differentiate malignant tumors from benign lumps and cysts.Type: ApplicationFiled: September 27, 2016Publication date: January 19, 2017Inventors: Alexander A. Oraevsky, Sergey A. Ermilov, Andre Conjusteau, Peter Brecht, Vyacheslav Nadvoretskiy, Richard Su, Donald G. Herzog, Bryan Clingman, Jason Zalev
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Publication number: 20140039293Abstract: An optoacoustic imaging system includes a hand-held imaging probe having a light emitting portion and an array of ultrasonic transducers. The probe includes an acoustic lens having an optically reflective material that operates to avoid image artifacts associated with light interactions with the acoustic lens. The optically reflective material may be a thin, highly optically reflective metallic layer. The acoustic lens may be formed from a material such as silicon rubber filled with titanium dioxide or barium sulfate that allows it to reflect and scatter light from illumination components with substantially no absorption of such light, and yet be optically opaque. The probe may include a housing that provides hypo-echoic encapsulation of the probe. An assembly of the array of ultrasonic transducers may include a hypo-echoic material. The probe may include optical windows, each comprising one or more anti-reflection-coated plates with acoustic impedance matching that of tissues to be imaged.Type: ApplicationFiled: January 22, 2013Publication date: February 6, 2014Applicant: Seno Medical Instruments, Inc.Inventors: Alexander A. Oraevsky, Sergey A. Ermilov, Andre Conjusteau, Peter Brecht, Vyacheslav Nadvoretskiy, Richard Su, Donald G. Herzog, Bryan Cingman, Jason Zalev
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Publication number: 20130301380Abstract: A real-time imaging method that provides ultrasonic imaging and optoacoustic imaging coregistered through application of the same hand-held probe to generate and detect ultrasonic and optoacoustic signals. These signals are digitized, processed and used to reconstruct anatomical maps superimposed with maps of two functional parameters of blood hemoglobin index and blood oxygenation index. The blood hemoglobin index represents blood hemoglobin concentration changes in the areas of diagnostic interest relative to the background blood concentration. The blood oxygenation index represents blood oxygenation changes in the areas of diagnostic interest relative to the background level of blood oxygenation. These coregistered maps can be used to noninvasively differentiate malignant tumors from benign lumps and cysts.Type: ApplicationFiled: November 2, 2012Publication date: November 14, 2013Inventors: Alexander A. Oraevsky, Sergey A. Ermilov, Adre Conjusteau, Peter Brecht, Vyacheslav Nadvoretskly, Richard Su, Donald G. Herzog, Bryan Clingman, Jason Zalev
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Publication number: 20130289381Abstract: A real-time imaging system that provides ultrasonic imaging and optoacoustic imaging coregistered through application of the same hand-held probe to generate and detect ultrasonic and optoacoustic signals. These signals are digitized, processed and used to reconstruct anatomical maps superimposed with maps of two functional parameters of blood hemoglobin index and blood oxygenation index. The blood hemoglobin index represents blood hemoglobin concentration changes in the areas of diagnostic interest relative to the background blood concentration. The blood oxygenation index represents blood oxygenation changes in the areas of diagnostic interest relative to the background level of blood oxygenation. These coregistered maps can be used to noninvasively differentiate malignant tumors from benign lumps and cysts.Type: ApplicationFiled: November 2, 2012Publication date: October 31, 2013Inventors: Alexander A. Oraevsky, Sergey A. Ermilov, Andre Conjusteau, Peter Brecht, Vyacheslav Nadvoretskiy, Richard Su, Donald G. Herzog, Bryan Clingman, Jason Zalev