Abstract: The present disclosure is directed to a computer-implemented method for designing a supply chain for multiple objectives based on a supply chain model. The method comprises defining a plurality of objectives for the supply chain model. The supply chain model includes a plurality of edges connecting one or more demands with one or more supplies. The method further includes selecting a first one of the plurality of objectives and at least a second one of the plurality of objectives and configuring, using a controller, the supply chain model for the first objective. The method further comprises identifying, using the controller, a subset of the plurality of edges based on the supply chain model configured for the first objective and relationships between the plurality of edges and the at least second objective. The method further comprises operating the supply chain according to the identified subset of the plurality of edges.

Abstract: A respiratory muscle training device includes a chamber (1) containing a variable orifice valve assembly (3). An inlet (9) is provided at a first side of the valve assembly permitting air to be inhaled into the chamber, and an outlet (11) is provided at a second side of the valve assembly permitting air that has passed through the valve assembly to be inhaled by a user. A pressure sensor (7) determines a pressure differential across the valve assembly. Means is provided for determining the opening area of the valve assembly, and control means (15, 47, 49) is provided for varying the orifice of the valve assembly in dependence upon a pressure differential determined by the pressure sensor and upon an opening area of the valve assembly.

Abstract: A respiratory muscle training device includes a chamber (1) containing a variable orifice valve assembly (3). An inlet (9) is provided at a first side of the valve assembly permitting air to be inhaled into the chamber, and an outlet (11) is provided at a second side of the valve assembly permitting air that has passed through the valve assembly to be inhaled by a user. A pressure sensor (7) determines a pressure differential across the valve assembly. Means is provided for determining the opening area of the valve assembly, and control means (15, 47, 49) is provided for varying the orifice of the valve assembly in dependence upon a pressure differential determined by the pressure sensor and upon an opening area of the valve assembly.