Patents by Inventor Peter Bruin
Peter Bruin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9901554Abstract: A special class of drug-depot forming triblock copolymers which are very suitable for the loading, containment and releasing of sensitive drugs such as proteins from biodegradable, injectable drug depots. How to visualize these depots for various imaging related purposes is described. A composition comprising a tri-block copolymer according to formula 1 B-A-B (1), wherein A stands for a linear poly-(ethylene glycol) block and wherein B stands for wherein B stands for a poly(lactide-co-?-caprolactone) block, wherein the hydroxyl end-groups of the tri-block copolymer are at least partially acylated with an optionally substituted acyl having 2 to 12 C-atoms, C-atoms of the substituents included; an active ingredient, preferably a pharmaceutically active ingredient and a solvent, wherein the block ratio of the tri-block copolymer, which ratio is defined as the ratio between the sum of the average molecular weight of the B-blocks and the sum of the average molecular weight of the A-block ranges from 1.4 to 3.5.Type: GrantFiled: April 2, 2012Date of Patent: February 27, 2018Assignee: INGELL TECHNOLOGIES HOLDING B.V.Inventors: Peter Bruin, Audrey Petit, Mike De Leeuw, Martin Piest, Ronald Meijboom
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Patent number: 9795679Abstract: Simple mixing/blending of a special class of drug-depot forming tri-block copolymers polymers, with the opportunity to cost-effectively tailor drug delivery performances of such biodegradable, injectable depots in a clinical and an industrial setting. How to visualize these depots for various imaging related purposes is described.Type: GrantFiled: April 2, 2012Date of Patent: October 24, 2017Assignee: INGELL TECHNOLOGIES HOLDING B.V.Inventors: Audrey Petit, Peter Bruin, Mike De Leeuw, Ronald Meijboom
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Publication number: 20160310643Abstract: The invention relates to a coating formulation for preparing medical coating, which coating formulation comprises (a) at least one multifunctional polymerizable compound according to a formula (I), wherein G is a residue of a polyfunctional compound having at least n functional groups, wherein each R1 and each R2 independently represents hydrogen or a group selected from substituted and unsubstituted hydrocarbons which optionally contain one or more heteroatoms, and wherein n is an integer having a value of at least 2; and (b) at least one inhibitor.Type: ApplicationFiled: January 28, 2016Publication date: October 27, 2016Inventors: Aylvin Jorge Angelo Athanasius DIAS, Edith Elisabeth M. VAN DEN BOSCH, Peter BRUIN, Marnix ROOIJMANS, Rudolfus Antonius Theordus Maria VAN BENTHEM
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Publication number: 20150165042Abstract: Simple mixing/blending of a special class of drug-depot forming tri-block copolymers polymers, with the opportunity to cost-effectively tailor drug delivery performances of such biodegradable, injectable depots in a clinical and an industrial setting. How to visualize these depots for various imaging related purposes is described.Type: ApplicationFiled: April 2, 2012Publication date: June 18, 2015Applicant: Ingell Technologies Holding B.V.Inventors: Audrey Petit, Peter Bruin, Mike De Leeuw, Ronald Meijboom
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Patent number: 8828546Abstract: The invention relates to an article comprising a coating, which coating comprises at least two layers, of which the inner layer is a primer layer, comprising a supporting network comprising a supporting polymer, and the outer layer is a functional layer comprising a multifunctional polymerizable compound.Type: GrantFiled: September 13, 2007Date of Patent: September 9, 2014Assignee: DSM IP Assets B.V.Inventors: Aylvin Jorge Angelo Athanasius Dias, Edith Elisabeth M. Van Den Bosch, Peter Bruin, Marnix Rooijmans, Rudolfus Antonius Theodorus Maria Van Benthem
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Publication number: 20140219923Abstract: A special class of drug-depot forming triblock copolymers which are very suitable for the loading, containment and releasing of sensitive drugs such as proteins from biodegradable, injectable drug depots. How to visualize these depots for various imaging related purposes is described. A composition comprising a tri-block copolymer according to formula 1 B-A-B (1), wherein A stands for a linear poly-(ethylene glycol) block and wherein B stands for wherein B stands for a poly(lactide-co-?-caprolactone) block, wherein the hydroxyl end-groups of the tri-block copolymer are at least partially acylated with an optionally substituted acyl having 2 to 12 C-atoms, C-atoms of the substituents included; an active ingredient, preferably a pharmaceutically active ingredient and a solvent, wherein the block ratio of the tri-block copolymer, which ratio is defined as the ratio between the sum of the average molecular weight of the B-blocks and the sum of the average molecular weight of the A-block ranges from 1.4 to 3.5.Type: ApplicationFiled: April 2, 2012Publication date: August 7, 2014Applicant: INGELL TECHNOLOGIES HOLDING B.V.Inventors: Peter Bruin, Audrey Petit, Mike De Leeuw, Martin Piest, Ronald Meijboom
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Publication number: 20140180221Abstract: The invention relates to an article comprising a coating, which coating comprises at least two layers, of which the inner layer is a primer layer, comprising a supporting network comprising a supporting polymer, and the outer layer is a functional layer comprising a multifunctional polymerizable compound.Type: ApplicationFiled: December 13, 2013Publication date: June 26, 2014Applicant: DSM IP ASSETS B.V.Inventors: Aylvin Jorge Angelo Athanasius DIAS, Edith Elisabeth M. VAN DEN BOSCH, Peter BRUIN, Marnix ROOIJMANS, Rudolfus Antonius Theodorus Maria VAN BENTHEM
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Publication number: 20100145018Abstract: Lipid conjugates of a poly-(amino acid), a poly-(amino acid derivative) or a poly-(amino acid analogue), such as poly-[N-(2-hydroxyethyl)-glutamine](PHEG), are provided.Type: ApplicationFiled: July 6, 2009Publication date: June 10, 2010Applicant: Astellas Pharma Europe BVInventors: Josbert Maarten Metselaar, Wilhelmus Everardus Hennick, Tom De Vringer, Leonardus Wilhelmus Theodorus De Boer, Christien Oussoren, Gerrit Storm, Peter Bruin
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Publication number: 20100114042Abstract: The invention relates to an article comprising a coating, which coating comprises at least two layers, of which the inner layer is a primer layer, comprising a supporting network comprising a supporting polymer, and the outer layer is a functional layer comprising a multifunctional polymerizable compound.Type: ApplicationFiled: September 13, 2007Publication date: May 6, 2010Inventors: Aylvin Jorge Angelo Athanasius Dias, Edith Elisabeth M> Van Den Bosch, Peter Bruin, Marnix Rooijmans, Rudolfus Antonius Theodorus Maria Van Benthem
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Publication number: 20100076546Abstract: The invention relates to a coating formulation for preparing a medical coating, which coating formulation comprises (a) at least one multifunctional polymerizable compound according to formula (I), wherein G is a residue of a polyfunctional compound having at least n functional groups, wherein each R1 and each R2 independently represents hydrogen or a group selected from substituted and unsubstituted hydrocarbons which optionally contain one or more heteroatoms, and wherein n is an integer having a value of at least 2; and (b) at least one initiator.Type: ApplicationFiled: September 13, 2007Publication date: March 25, 2010Applicant: DSM IP ASSETS B.V.Inventors: Aylvin Jorge Angelo Athanasius Dias, Edith Elizabeth M. Van Den Bosch, Peter Bruin, Marnix Rooijmans, Rudolfus Antonius Theodorus Maria Van Benthem
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Publication number: 20100068252Abstract: The present invention relates to a method for the preparation of a drug loaded matrix with a pharmaceutical compound by polymerizing a polymerisation mixture by radiation in the presence of at least one sensitive pharmaceutical compound, wherein the polymerisation mixture comprises a) at least one polymerisable compound b) optionally at least one photoinitiator c) optionally at least one additive which are chosen such that the sensitive pharmaceutical compound is degraded less than 2%, or which are chosen such that the sensitive pharmaceutical compound is protected against degradation such that the degradation is about 50% or less when compared to radiation with a constituent that produce radical.Type: ApplicationFiled: June 12, 2007Publication date: March 18, 2010Applicant: DSM IP ASSETS B.V.Inventors: Aylvin Jorge Angelo Anthasius Dias, Peter Bruin, Audrey Petit
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Publication number: 20060062179Abstract: A broadcast channel, such as a broadcast control channel that carries a short message service, in a GSM/EDGE or similar communication system can be extended with additional timeslots. These additional timeslots can be pointed out in a tree structure, the root of which is in the SMS broadcast channel. The extended broadcast channel can be used for broadcast-like services provided under a multimedia broadcast/multicast service.Type: ApplicationFiled: September 14, 2005Publication date: March 23, 2006Inventors: Arne Simonsson, Tor Minde, Peter Bruin
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Publication number: 20040254352Abstract: Lipid conjugates of a poly-(amino acid), a poly-(amino acid derivative) or a poly-(amino acid analogue), such as poly-[N-(2-hydroxyethyl)-glutamine](PHEG), are provided.Type: ApplicationFiled: July 23, 2004Publication date: December 16, 2004Inventors: Josbert Maarten Metselaar, Wilhelmus Everardus Hennick, Tom De Vringer, Leonardus Wilhelmus Theodorus De Boer, Christien Oussoren, Gerrit Storm, Peter Bruin
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Publication number: 20040241222Abstract: Colloidal carrier compositions, comprising an active agent and a lipid conjugate of a poly-(amino acid), a poly-(amino acid derivative) or poly-(amino acid analogue), such as poly-[N-(2-hydroxyethyl)-glutamine] (PHEG), are provided.Type: ApplicationFiled: June 17, 2004Publication date: December 2, 2004Inventors: Josbert Maarten Metselaar, Wilhelmus Evardus Hennick, Tom De Vringer, Leonardus Wilhelmus Theodorus De Boer, Christien Oussoren, Gerrit Storm, Peter Bruin