Abstract: The present disclosure describes devices and methods for detecting motoneuron excitability in a subject in need. The method includes stimulating a cutaneous distribution of a patient's vagus nerve within a patient's ear with a nerve stimulating signal; detecting F-wave occurrence with an evoked electromyography paradigm; and adjusting one or more parameters of the nerve stimulating signal to change the F-wave occurrence.

Abstract: Computing systems and computer-implemented methods for removing brain stimulation artifacts in neural signals are disclosed. The method makes use of a matching pursuit algorithm to accurately extract the stimulation artifact. The disclosed method removes the stimulation artifact associated with individual stimulation pulses without needing additional information from previous stimulation pulses or other electrodes. The disclosed method is compatible for use with various stimulation frequencies, does not need any filtering, and can recover neural signals almost immediately after stimulation. The disclosed method is compatible for use in has great potential in closed-loop systems used in various neurological diagnostic and therapeutic procedures.

Abstract: Among the various aspects of the present disclosure is the provision for systems and methods that employ a multielectrode transdermal spinal stimulation (tSCS) device configured to provide spatiotemporal transcutaneous spinal cord stimulation. In some aspects, the predetermined pattern is configured to sequentially activate and recruit individual muscle groups in a sequence configured to assist in the subject's movements such as walking. Among various other aspects a non-invasive brain-spine interface (BSI) system is disclosed that facilitate movements such as leg movements in a subject with a spinal cord injury (SCI). The BSI system includes a wearable EEG array to monitor brain activity, and a computer to identify intended movement by the subject based on the monitored brain activity. In response to the detection of an intended movement by the BSI system, the tSCS device activates the multielectrode transdermal spinal stimulation device to facilitate the intended movement of the subject.

Abstract: The present disclosure describes devices and methods for detecting motoneuron excitability in a subject in need. The method includes stimulating a cutaneous distribution of a patient's vagus nerve within a patient's ear with a nerve stimulating signal; detecting F-wave occurrence with an evoked electromyography paradigm; and adjusting one or more parameters of the nerve stimulating signal to change the F-wave occurrence.

Abstract: The present disclosure relates to a fashion article or textile article, such as a cap 100, with a magnetically attachable and/or detachable patch element 200. Furthermore, the present disclosure relates to a patch element 200 magnetically attachable to the textile article or fashion article, such as the cap 100, and to a textile article or fashion article, such as the cap 100, configured to magnetically attach the magnetically attachable patch element 200.

Abstract: A method of enhanced motor learning is provided. The method includes stimulating a cutaneous distribution of a patient's vagus nerve within the patient's ear with a nerve stimulating signal. The method also includes assisting the patient in performing a physical activity while the patient's vagus nerve is stimulated. The method further includes monitoring one or more statistics of the patient during the physical activity.

Abstract: Among the various aspects of the present disclosure is the provision for systems and methods for individualized targeting of deep brain stimulation (DBS). In addition, methods for monitoring the treatment of a subject using a DBS system are described.

Abstract: Systems and methods for detecting oscillations in neural signals are disclosed that provide for high precision and specificity in detecting neural oscillations in time and frequency domains. The disclosed systems and methods identify oscillations according to criteria including 1/f noise, number of cycles, and auto-correlation. The disclosed method detects periodic signals and filters out spurious oscillations associated with harmonic frequencies.

Abstract: Among the various aspects of the present disclosure is the provision of devices, systems, and methods for tracking the positions and orientations of at least one bone screw implanted within a surgical site. The disclosed device includes an extension that includes an extension base configured to couple to the bone screw, a marker arm coupled at one end to the extension base in a hinged arrangement, and an optical marker attached to a free end of the marker arm opposite the hinged attachment. The optical marker includes a pair of lenticular arrays in a coplanar arrangement in which the major axes of the lenticular arrays are mutually perpendicular. Each lenticular array is configured to display different hues at different viewing angles. The disclosed method includes transforming a single image of a surgical site containing at least one bone screw and extension into the global positions of each bone screw based on the pixel positions and hues corresponding to the lenticular arrays of each optical marker.

Abstract: The present disclosure relates to a fashion article or textile article, such as a cap 100, with a magnetically attachable and/or detachable patch element 200. Furthermore, the present disclosure relates to a patch element 200 magnetically attachable to the textile article or fashion article, such as the cap 100, and to a textile article or fashion article, such as the cap 100, configured to magnetically attach the magnetically attachable patch element 200.

Abstract: Computing systems and computer-implemented methods for removing brain stimulation artifacts in neural signals are disclosed. The method makes use of a matching pursuit algorithm to accurately extract the stimulation artifact. The disclosed method removes the stimulation artifact associated with individual stimulation pulses without needing additional information from previous stimulation pulses or other electrodes. The disclosed method is compatible for use with various stimulation frequencies, does not need any filtering, and can recover neural signals almost immediately after stimulation. The disclosed method is compatible for use in has great potential in closed-loop systems used in various neurological diagnostic and therapeutic procedures.

Abstract: The present disclosure describes devices and methods for detecting motoneuron excitability in a subject in need. The method includes stimulating a cutaneous distribution of a patient’s vagus nerve within a patient’s ear with a nerve stimulating signal; detecting F-wave occurrence with an evoked electromyography paradigm; and adjusting one or more parameters of the nerve stimulating signal to change the F-wave occurrence.

Abstract: Methods and systems are disclosed for analyzing interactions between low-frequency oscillations and high-frequency activity in electromagnetic brain signals such as EEG, MEG, SEEG, and ECoG signals in subjects in real-time that does not depend on the signals being contained within narrow frequency bands, sinusoidal, sustained and monolithic. The disclosed methods and systems can be applied to electromagnetic brain signals to detect brain activity alterations associated with neurological and psychiatric diseases.

Abstract: The present invention includes a responsive neural stimulator having electrodes, a filter, a processor, a recording medium, an extractor for extracting instantaneous voltage amplitudes of biased oscillatory activity with asymmetrically distributed peak/trough amplitudes, and a neural stimulator connected to the processor configured to apply neural stimulation via the neural stimulator when a predetermined state of neuronal excitability is detected, a state of relatively higher neuronal excitability corresponding to a relatively lower instantaneous voltage amplitude extracted by the extractor.

Abstract: An implant includes an implant body sized and shaped for insertion into a sacro-iliac joint, the implant including a first bone fixation element receiving channel extending through a portion thereof along a first central axis oriented so that, when the implant body is received within the sacro-iliac joint in a desired configuration, a bone fixation element inserted into the first bone fixation element receiving channel will extend into a first one of the bones forming the joint.

Abstract: An implant includes first thermoplastic material portions, and second thermoplastic material portions liquefiable by mechanical vibrations and being in contact with the first thermoplastic material portions, wherein the second thermoplastic material portions preferably constitute at least a part of a surface of the implant, and wherein the first thermoplastic material portions have a glass transition temperature above an implantation temperature (about 20° C. to 40° C.), and wherein the second thermoplastic material portions either have a glass transition temperature below the implantation temperature or are able to transform non-mechanical energy into heat.

Abstract: The present invention includes a responsive neural stimulator having electrodes, a filter, a processor, a recording medium, an extractor for extracting instantaneous voltage amplitudes of biased oscillatory activity with asymmetrically distributed peak/trough amplitudes, and a neural stimulator connected to the processor configured to apply neural stimulation via the neural stimulator when a predetermined state of neuronal excitability is detected, a state of relatively higher neuronal excitability corresponding to a relatively lower instantaneous voltage amplitude extracted by the extractor.

Abstract: The invention relates to a method and a device for generating a nanoaerosol, wherein at least one fluid to be atomized is atomized in a nozzle via a nozzle opening of the nozzle along a discharge direction in the form of fluid particles, the atomized fluid particles are deflected from the discharge direction and larger fluid particles are at least partially separated from smaller fluid particles, the separated larger fluid particles are returned to the fluid to be atomized and the smaller fluid particles are dispensed onto the environment. A cartridge in which the nozzle and the fluid to be atomized are arranged is used. According to the invention, a stream of a carrier gas is generated in the nozzle and at least one fluid to be atomized is brought into contact with the carrier gas.

Abstract: The present invention provides methods, devices, and systems for restoring or improving nervous system function of a subject. Provided is a method involving: (i) providing an operant conditioning protocol effective to produce targeted neural plasticity (TNP) in a primary targeted central nervous system (CNS) pathway of a subject; and (ii) administering the operant conditioning protocol to the subject to elicit TNP in the primary targeted CNS pathway and to elicit generalized neural plasticity (GNP) in one or more other CNS pathway. The elicitation of the GNP in the one or more other CNS pathway serves to restore or improve a nervous system function of the subject. Provided is a device comprising a nerve stimulation-electromyographic recording component and a controller for operating the nerve stimulation-electromyographic recording component in accordance with an operant conditioning protocol.

Abstract: A device for detachably clamping fastening elements in a surgical fixing or repositioning device. The device may a rod with a longitudinal axis. A first and second pair of clamping jaws may be operably associated with the rod. Each pair of clamping jaws may have a side surface as well as an inner clamping jaw and an outer clamping jaw, which may have indentations forming a channel. The channels may be opened towards the side surface of the clamping jaws. A fastening means may be positioned in the channels by pushing the fastening means into the openings in the side surface in a direction which may be at an angle with respect to the longitudinal axis of the rod. An elastic element may be positioned between the inner and outer clamping jaws of at least one pair of clamping jaws so as to resist movement of the inner and outer clamping jaws with respect to each other as a fastening means is inserted therebetween.