Patents by Inventor Peter Brunner

Peter Brunner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10684291
    Abstract: The present description relates to a method for identifying a patient who is eligible for an intensification of heart failure therapy. Furthermore, the description relates to a method for optimizing B type natriuretic peptide (BNP) and/or N-terminal pro B-type natriuretic peptide (NT-proBNP)-type peptide guided heart failure therapy. The methods are based on the measurement of the level of at least one marker in a sample from a patient who has heart failure and who receives B-type natriuretic peptide (BNP) and/or N-terminal pro B-type natriuretic peptide (NT-proBNP)-type peptide guided heart failure therapy. Further described are kits and devices adapted to carry out the described method.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: June 16, 2020
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Dirk Block, Hans-Peter Brunner, Ursula-Henrike Wienhues-Thelen, Christian Zaugg, Thomas Dieterle, Cheryl Mitchell, Johan Ubby, Sandra Sanders-van Wijk
  • Publication number: 20200126285
    Abstract: A graphics animation and compositing operations framework has a layer tree for interfacing with the application and a render tree for interfacing with a render engine. Layers in the layer tree can be content, windows, views, video, images, etc., for an application's user interface. The application commits state changes of the layers of the layer tree. The application does not need to include explicit code for animating the changes to the layers. Instead, after a synchronization threshold has been met, an animation is determined for animating the change in state by the framework which can define a set of predetermined animations based on motion, visibility and transition. The determined animation is explicitly applied to the affected layers in the render tree. A render engine renders from the render tree into a frame buffer, synchronized with the display. Portions of the render tree changing relative to prior versions can be tracked.
    Type: Application
    Filed: December 20, 2019
    Publication date: April 23, 2020
    Inventors: Ralph Brunner, John Harper, Peter Graffagnino
  • Patent number: 10605429
    Abstract: The invention relates to a motor vehicle headlight (100), comprising a headlight housing (102) and a cover plate (103) having at least one light source (104, 105) arranged in said motor vehicle headlight (100). In order to cool the at least one light source (104, 105), a heat sink device (200) is provided. Said heat sink device (200) comprises two heat sink elements (106, 107, 201, 202, 501, 502, 601, 602, 701, 702, 801, 802, 901, 902, 1001, 1002) that are separated from one another by an air gap (209) and that are arranged in such a way that a first heat sink element (106, 201, 501, 601, 701, 801, 901, 1001) is mounted inside the motor vehicle headlight (100), and a second heat sink element (107, 202, 502, 602, 702, 802, 902, 1002) is mounted outside the motor vehicle headlight (100).
    Type: Grant
    Filed: October 25, 2017
    Date of Patent: March 31, 2020
    Assignee: ZKW GROUP GMBH
    Inventors: Peter Mayer, Michael Brunner, Martin Ebner
  • Publication number: 20200072435
    Abstract: The invention relates to a motor vehicle headlight (100), comprising a headlight housing (102) and a cover plate (103) having at least one light source (104, 105) arranged in said motor vehicle headlight (100). In order to cool the at least one light source (104, 105), a heat sink device (200) is provided. Said heat sink device (200) comprises two heat sink elements (106, 107, 201, 202, 501, 502, 601, 602, 701, 702, 801, 802, 901, 902, 1001, 1002) that are separated from one another by an air gap (209) and that are arranged in such a way that a first heat sink element (106, 201, 501, 601, 701, 801, 901, 1001) is mounted inside the motor vehicle headlight (100), and a second heat sink element (107, 202, 502, 602, 702, 802, 902, 1002) is mounted outside the motor vehicle headlight (100).
    Type: Application
    Filed: October 25, 2017
    Publication date: March 5, 2020
    Inventors: Peter MAYER, Michael BRUNNER, Martin EBNER
  • Patent number: 10521949
    Abstract: A graphics animation and compositing operations framework has a layer tree for interfacing with the application and a render tree for interfacing with a render engine. Layers in the layer tree can be content, windows, views, video, images, text, media or other type of objects for an application's user interface. The application commits state changes of the layers of the layer tree. The application does not need to include explicit code for animating the changes to the layers. Instead, after a synchronization threshold has been met, an animation is determined for animating the change in state by the framework which can define a set of predetermined animations based on motion, visibility and transition. The determined animation is explicitly applied to the affected layers in the render tree. A render engine renders from the render tree into a frame buffer, synchronized with the display. Portions of the render tree changing relative to prior versions can be tracked to improve resource management.
    Type: Grant
    Filed: November 13, 2017
    Date of Patent: December 31, 2019
    Assignee: Apple Inc.
    Inventors: Ralph Brunner, John Harper, Peter Graffagnino
  • Patent number: 10478086
    Abstract: The present invention includes a responsive neural stimulator having electrodes, a filter, a processor, a recording medium, an extractor for extracting instantaneous voltage amplitudes of biased oscillatory activity with asymmetrically distributed peak/trough amplitudes, and a neural stimulator connected to the processor configured to apply neural stimulation via the neural stimulator when a predetermined state of neuronal excitability is detected, a state of relatively higher neuronal excitability corresponding to a relatively lower instantaneous voltage amplitude extracted by the extractor.
    Type: Grant
    Filed: March 17, 2016
    Date of Patent: November 19, 2019
    Assignee: HEALTH RESEARCH, INC.
    Inventors: Gerwin Schalk, Peter Brunner, William G. Coon, Adriana De Pesters
  • Publication number: 20190337044
    Abstract: A method for producing a heat exchange tube having an inner turbulence insert for a heat exchanger may include providing an austenitic heat exchange tube and the turbulence insert. The method may also include inserting the turbulence insert into the austenitic heat exchange tube, brazing the turbulence insert and the austenitic heat exchange tube via induction brazing, and pressing the austenitic heat exchange tube onto the turbulence insert at least one of during the brazing and after the brazing.
    Type: Application
    Filed: July 20, 2017
    Publication date: November 7, 2019
    Inventors: Steffen Brunner, Steffen Ensminger, Peter Geskes, Eberhard Pantow
  • Publication number: 20190274580
    Abstract: A system for EIT imaging comprises an electrode array for positioning on a patient and measuring an impedance distribution, a data entry unit and a calculation unit. The electrode array contains a visual aid coupled to the electrode array for visually indicating the position of at least one electrode, the data entry module accepts an entry of data describing the position of the visual aid, and the calculation unit calculates the position of the individual electrodes relative to the patient's body and provides correction for the image creation algorithm. A sensor device for EIT imaging may comprise the electrode array, which is connectable to an EIT imaging system comprising a data entry unit and a calculation unit. An EIT imaging method may employ the system or sensor device.
    Type: Application
    Filed: November 11, 2017
    Publication date: September 12, 2019
    Inventors: Peter Krammer, Andreas Waldmann, Josef Brunner
  • Publication number: 20190277861
    Abstract: The present disclosure relates to a method for diagnosing and/or grading diastolic dysfunction or at least one structural or functional abnormality associated with diastolic dysfunction. The method involves measuring the level of IGFBP7 (Insulin like growth factor binding protein 7) and, optionally, the level of at least one further marker in a patient suffering from heart failure, and comparing the level to a reference level. Further envisaged is a method of monitoring diastolic function in a patient suffering from heart failure. Also encompassed by the present disclosure are kits and devices adapted to carry out the method of the present invention.
    Type: Application
    Filed: May 23, 2019
    Publication date: September 12, 2019
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Johann Karl, Ursula-Henrike Wienhues-Thelen, Dirk Block, Christian Zaugg, Hans-Peter Brunner, James Januzzi, Andre Ziegler, Julian Braz, Thomas Dieterle, Edelgard Kaiser
  • Patent number: 10402934
    Abstract: Disclosed is a system for producing images including techniques for reducing the memory and processing power required for such operations. The system provides techniques for programmatically representing a graphics problem. The system further provides techniques for reducing and optimizing graphics problems for rendering with consideration of the system resources, such as the availability of a compatible GPU.
    Type: Grant
    Filed: June 21, 2017
    Date of Patent: September 3, 2019
    Assignee: Apple Inc.
    Inventors: John Harper, Ralph Brunner, Peter Graffagnino, Mark Zimmer
  • Publication number: 20190248651
    Abstract: An ozone generator of a gas blow-through type, especially to produce a gas mixture of ozone/air or ozone/oxygen. An ozone producing structural unit in the path of the blown air or oxygen is used as ozone source. The ozone producing structural unit is operated on the principle of alternating current auxiliary electrode cold arc discharge with its capacity increased by limited arc discharge, with an alternating voltage voltage source. This solution does not result in high-temperature arc discharges, thus the fire hazard may be eliminated, and at the same time the device is capable of producing extremely large quantities of ozone. The ozone producing structural unit of the ozone generator is placed in one or more insulating housings/air ducts, placed in a direction parallel to or coaxial to the air blowing direction. Further details of the apparatus are disclosed herein.
    Type: Application
    Filed: July 4, 2017
    Publication date: August 15, 2019
    Inventors: Rita BRUNNER, Péter KOLTAY
  • Patent number: 10345315
    Abstract: Disclosed herein is a method for diagnosing and/or grading diastolic dysfunction or at least one structural or functional abnormality associated with diastolic dysfunction. The method involves measuring the level of IGFBP7 (Insulin like growth factor binding protein 7) and, optionally, the level of at least one further marker in a patient suffering from heart failure, and comparing the level to a reference level. Also disclosed is a method of monitoring diastolic function in a patient suffering from heart failure, and kits and devices for performing the method.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: July 9, 2019
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Johann Karl, Ursula-Henrike Wienhues-Thelen, Dirk Block, Christian Zaugg, Hans-Peter Brunner, James Januzzi, Andre Ziegler, Julian Braz, Thomas Dieterle, Edelgard Kaiser
  • Publication number: 20190154706
    Abstract: The present invention is directed to a method of identifying a patient having heart failure as likely to respond to a therapy comprising a statin. The method is based on measuring the level of at least one marker selected from GDF-15 (Growth Differentiation Factor 15), Urea, SHBG (Sex Hormone-Binding Globulin), Uric acid, PLGF (Placental Growth Factor), IL-6 (Interleukin-6), Transferrin, a cardiac Troponin, sFlt-1 (Soluble fms-like tyrosine kinase-1), Prealbumin, Ferritin, Osteopontin, sST2 (soluble ST2), and hsCRP (high sensitivity C-reactive protein) in a sample from a patient. Further envisaged is a method of predicting the risk of a patient to suffer from death or hospitalization, wherein said patient has heart failure and undergoes a therapy comprising a statin. The method is also based on the measurement of the level of at least one of the aforementioned markers.
    Type: Application
    Filed: January 25, 2019
    Publication date: May 23, 2019
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Dirk Block, Hans-Peter Brunner, Thomas Dieterle, Ursula-Henrike Wienhues-Thelen, Christian Zaugg, Andre Ziegler
  • Patent number: 10278742
    Abstract: An implant includes an implant body sized and shaped for insertion into a sacro-iliac joint, the implant including a first bone fixation element receiving channel extending through a portion thereof along a first central axis oriented so that, when the implant body is received within the sacro-iliac joint in a desired configuration, a bone fixation element inserted into the first bone fixation element receiving channel will extend into a first one of the bones forming the joint.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: May 7, 2019
    Assignee: DePuy Synthes Products, Inc.
    Inventors: Paul Pavlov, Tom Overes, Peter Brunner
  • Patent number: 10234464
    Abstract: The present invention is directed to a method of identifying a patient having heart failure as likely to respond to a therapy comprising a statin. The method is based on measuring the level of at least one marker selected from GDF-15 (Growth Differentiation Factor 15), Urea, SHBG (Sex Hormone-Binding Globulin), Uric acid, PLGF (Placental Growth Factor), IL-6 (Interleukin-6), Transferrin, a cardiac Troponin, sFlt-1 (Soluble fms-like tyrosine kinase-1), Prealbumin, Ferritin, Osteopontin, sST2 (soluble ST2), and hsCRP (high sensitivity C-reactive protein) in a sample from a patient. Further envisaged is a method of predicting the risk of a patient to suffer from death or hospitalization, wherein said patient has heart failure and undergoes a therapy comprising a statin. The method is also based on the measurement of the level of at least one of the aforementioned markers.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: March 19, 2019
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Dirk Block, Hans-Peter Brunner, Thomas Dieterle, Ursula-Henrike Wienhues-Thelen, Christian Zaugg, Andre Ziegler
  • Publication number: 20180313850
    Abstract: The present invention relates to a method for guiding heart failure treatment in a subject suffering from heart failure. The method is based on the determination of the amount of a BNP-type peptide and a cardiac troponin in a sample from said subject. Further envisaged by the present invention are kits and devices adapted to carry out the present invention. The present invention also relates to a system for guiding heart failure treatment in a subject suffering from heart failure as disclosed herein and to reagents and kits used in performing the methods disclosed herein.
    Type: Application
    Filed: July 5, 2018
    Publication date: November 1, 2018
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Dirk Block, Julian Braz, Hans-Peter Brunner, James Creeden, Hans-Joerg Loyda, Ursula-Henrike Wienhues-Thelen, Christian Zaugg
  • Patent number: 10058412
    Abstract: An implant includes first thermoplastic material portions, and second thermoplastic material portions liquefiable by mechanical vibrations and being in contact with the first thermoplastic material portions, wherein the second thermoplastic material portions preferably constitute at least a part of a surface of the implant, and wherein the first thermoplastic material portions have a glass transition temperature above an implantation temperature (about 20° C. to 40° C.), and wherein the second thermoplastic material portions either have a glass transition temperature below the implantation temperature or are able to transform non-mechanical energy into heat.
    Type: Grant
    Filed: September 22, 2014
    Date of Patent: August 28, 2018
    Assignee: WOODWELDING AG
    Inventors: Jörg Mayer, Andrea Muller, Peter Brunner
  • Publication number: 20180070847
    Abstract: The present invention includes a responsive neural stimulator having electrodes, a filter, a processor, a recording medium, an extractor for extracting instantaneous voltage amplitudes of biased oscillatory activity with asymmetrically distributed peak/trough amplitudes, and a neural stimulator connected to the processor configured to apply neural stimulation via the neural stimulator when a predetermined state of neuronal excitability is detected, a state of relatively higher neuronal excitability corresponding to a relatively lower instantaneous voltage amplitude extracted by the extractor.
    Type: Application
    Filed: March 17, 2016
    Publication date: March 15, 2018
    Applicant: HEALTH RESEARCH, INC.
    Inventors: Gerwin SCHALK, Peter BRUNNER, William G. COON, Adriana DE PESTERS
  • Patent number: 9566211
    Abstract: The invention relates to a method and a device for generating a nanoaerosol, wherein at least one fluid to be atomized is atomized in a nozzle via a nozzle opening of the nozzle along a discharge direction in the form of fluid particles, the atomized fluid particles are deflected from the discharge direction and larger fluid particles are at least partially separated from smaller fluid particles, the separated larger fluid particles are returned to the fluid to be atomized and the smaller fluid particles are dispensed onto the environment. A cartridge in which the nozzle and the fluid to be atomized are arranged is used. According to the invention, a stream of a carrier gas is generated in the nozzle and at least one fluid to be atomized is brought into contact with the carrier gas.
    Type: Grant
    Filed: June 17, 2010
    Date of Patent: February 14, 2017
    Assignee: Medic Activ Vertriebs GmbH
    Inventors: Peter Brunner, Hans Peter Zarfl, Bernd Heiko Lindena
  • Patent number: 9545515
    Abstract: The present invention provides methods, devices, and systems for restoring or improving nervous system function of a subject. Provided is a method involving: (i) providing an operant conditioning protocol effective to produce targeted neural plasticity (TNP) in a primary targeted central nervous system (CNS) pathway of a subject; and (ii) administering the operant conditioning protocol to the subject to elicit TNP in the primary targeted CNS pathway and to elicit generalized neural plasticity (GNP) in one or more other CNS pathway. The elicitation of the GNP in the one or more other CNS pathway serves to restore or improve a nervous system function of the subject. Provided is a device comprising a nerve stimulation-electromyographic recording component and a controller for operating the nerve stimulation-electromyographic recording component in accordance with an operant conditioning protocol.
    Type: Grant
    Filed: September 16, 2015
    Date of Patent: January 17, 2017
    Assignee: Health Research, Inc.
    Inventors: Jonathan R. Wolpaw, Gerwin Schalk, Aiko K. Thompson, Peter Brunner, Xiang Yang Chen, Dennis J. McFarland