Abstract: Provided herein are small molecule inhibitors of coronavirus attachment and entry, related pharmaceutical compositions, uses, and methods thereof, wherein the compound has a structure of Formula (I):

Abstract: Disclosed herein are methods for treating/and or preventing diabetes using a specific inhibitor of SMAD7 expression or function. Also disclosed are methods of promoting organ and/or cell, e.g., pancreatic islet cell, survival after transplantation using a specific inhibitor of SMAD7 expression or function.

Abstract: Disclosed herein are inhibitors of TNF superfamily costimulatory interactions, and methods for their use in modulating TNF superfamily costimulatory interactions and treating immune system related disorders. In particular, disclosed herein are compounds of Formula (I), and pharmaceutically acceptable salts thereof: wherein the substituents are described herein.

Abstract: Disclosed herein are methods for treating/and or preventing diabetes using a specific inhibitor of SMAD7 expression or function. Also disclosed are methods of promoting organ and/or cell, e.g., pancreatic islet cell, survival after transplantation using a specific inhibitor of SMAD7 expression or function.

Abstract: Disclosed herein are methods for treating/and or preventing diabetes using a specific inhibitor of SMAD7 expression or function. Also disclosed are methods of promoting organ and/or cell, e.g., pancreatic islet cell, survival after transplantation using a specific inhibitor of SMAD7 expression or function.

Abstract: Disclosed herein are inhibitors of TNF superfamily costimulatory interactions, and methods for their use in modulating TNF superfamily costimulatory interactions and treating immune system related disorders. In particular, disclosed herein are compounds of Formula (I), and pharmaceutically acceptable salts thereof: wherein the substituents are described herein.

Abstract: Disclosed herein are methods for treating/and or preventing diabetes using a specific inhibitor of SMAD7 expression or function. Also disclosed are methods of promoting organ and/or cell, e.g., pancreatic islet cell, survival after transplantation using a specific inhibitor of SMAD7 expression or function.

Abstract: Disclosed herein are methods for treating/and or preventing diabetes using a specific inhibitor of SMAD7 expression or function. Also disclosed are methods of promoting organ and/or cell, e.g., pancreatic islet cell, survival after transplantation using a specific inhibitor of SMAD7 expression or function.

Abstract: A device (10) for receiving implanted biological material includes a mechanoprotective surface (16) defining an adjacent space, an assembly (26, 28) for locally delivering media to said space, and a pump or slow/sustained release reservoir structure (14) operatively coupled to the assembly. The device may comprise an additional plunger body for being disposed in said space. The implanted biological material may be encapsulated or non-encapsulated.

Abstract: The present invention provides highly porous, biocompatible and biostable scaffold constructs for improving overall cell engraftment, survival, function and long-term viability. These scaffolds can provide mechanical protection to implanted cells, afford retrievability from a subject, and allow for both intra-device vascularization and a means to spatially distribute the cells within the device. The scaffold surface or material may be modified with one or more different adhesion proteins and optionally other biological factors for enhanced cell adherence and viability. Further, the scaffold surface or material may be modified with one or more agents with slow/sustained release characteristics to aid engraftment, survival, function or long-term viability. Implanted cells of the invention may be insulin-producing cells such as islets.

Abstract: Azo dyes and suramin-related small molecules are effective in inhibiting the CD40/CD154 protein-protein interaction, an important co-stimulatory interaction involved in the activation of immune responses mediated by T- and B-cells. The compounds were found to be active as indicated by their IC50 values both in a cell-free binding assay and in the inhibition of CD154-induced B-cell proliferation assay. The compounds may be used as therapeutic compounds for treatment of diseases and disorders related to immune or inflammatory responses. Methods of inhibiting the CD40/CD154 protein-protein interaction and treating diseases and disorders related to immune or inflammatory responses are described.

Abstract: A device (10) for receiving implanted biological material includes a mechanoprotective surface (16) defining an adjacent space, an assembly (26, 28) for locally delivering media to said space, and a pump or slow/sustained release reservoir structure (14) operatively coupled to the assembly. The device may comprise an additional plunger body for being disposed in said space. The implanted biological material may be encapsulated or non-encapsulated.

Abstract: In the present method for producing a planar element (2) for car bodies in differential construction, which includes an external skin (4) and at least one stiffening means implemented as planar, profiles (8) and profile nodes (10) being provided in a predetermined arrangement on the external skin (4), in a first step the stiffening means is glued to the external skin (4), in a second step profiles (8) and profile nodes (10) are arranged and joined into a frame, at least partially using a cold joining method, and in a third step the frame is joined to the external skin (4) on the side of the stiffening means, at least partially using a cold joining method. High planar buckling resistance of the plate panels is achieved through these measures.

Abstract: In the present method for producing a planar element (2) for car bodies in sandwich construction, which includes an external skin (4) and a hump plate (6) having edge profiles (8, 10) arranged between them, in a first step the edge profiles (8, 10) are joined to the hump plate (6), at least partially using a mechanical joining method, in a second step the hump plate (6) is glued to the external skin (4), and in a third step the edge profiles (8, 10) are joined to the external skin (4), at least partially using a mechanical joining method. Through these measures, high shear and buckling resistance of the planar element is achieved.

Abstract: In a television receiving section for receiving an analog television signal converted to an intermediate frequency by a mixer (3) and subsequently selected in an intermediate frequency filter (6) which is followed by an A/D converter (7), the intermediate frequency is an integral multiple of the sample clock frequency of the A/D converter (7) for the purpose of simultaneous demodulation of the television signal.

Abstract: In an installation for deep-drawing and back-foaming of upholstery covers, the deep-drawing molds are disposed on a round table. Besides the round table for the deep-drawing molds, a stationary stretch piston station is provided, serving all deep-drawing molds on the round table passing the stretch piston station.

Abstract: A process for increasing the resolution of color television solid state cameras provided with three semiconductor image sensors, each assembled of an array of optoelectric elements, includes: geometrically offsetting the sensors in horizontal direction by one third of the distance between the optoelective elements; phase-shifting scanning signals applied to respective sensors by 120.degree.; generating standard signals for luminance and chrominance and matrixing an additional luminance signal; low-pass filtering the standard signals and high-pass filtering the additional luminance signal; and adding the filtered standard and additional luminance signals to produce a resultant luminance signal of higher resolution. A control signal is derived from the high-pass filtered additional luminance signal and is used for controlling amplitudes of the color-difference signals.