Abstract: The present invention features methods, devices, and kits for detecting gene expression in a patient with a cancer or determining responsive of a patient with a cancer to a treatment, such as treatment with dovitinib or a pharmaceutically acceptable salt thereof. The invention further includes methods of treating a patient with a cancer by administering a treatment, e.g., treatment with dovitinib or a pharmaceutically acceptable salt thereof, in particular when the patient is determined to be responsive to the treatment based on the expression of the biomarkers described herein.

Abstract: The present invention features methods, devices, and kits for detecting gene expression in a patient with a cancer or determining responsive of a patient with a cancer to a treatment, such as treatment with dovitinib or a pharmaceutically acceptable salt thereof. The invention further includes methods of treating a patient with a cancer by administering a treatment, e.g., treatment with dovitinib or a pharmaceutically acceptable salt thereof, in particular when the patient is determined to be responsive to the treatment based on the expression of the biomarkers described herein.

Abstract: Featured are methods of treating a patient with cancer by administering, e.g., a secretory phospholipase A2 (sPLA2) hydrolysable, cisplatin-containing liposome composition (e.g., LiPlaCis). The patient may be assessed for their responsiveness to the liposomal therapy prior to treatment using the methods, devices, and kits also described herein for detecting a level of one or more biomarkers in a sample from the patient with cancer.

Abstract: The present invention relates to a method of treatment of a tumour cell which comprises administering to a subject in need of treatment an effective amount of a topoisomerase-II poison, e.g. etoposide, in combination with a bis-dioxypiperazine, e.g. dexrazoxane wherein said subject is further treated with radiation.

Abstract: The present invention relates generally to the treatment of diseases and disorders that are mediated by histone deacetylase (HDAC), for example, cancer, with Belinostat™ (also known as (E)-N-hydroxy-3-(3-phenylsulfamoyl-phenyl)-acrylamide; PXD101; and PX 105684), and more particularly, to improvement treatments of such diseases (for example, cancers, for example, leukemias), which employ prolonged continuous infusion (e.g., prolonged continuous intravenous infusion) of Belinostat™.

Abstract: The invention relates to an assembly for use in automation and process measurement technology, comprising an at least two-part compact housing having a sleeve-shaped housing bottom part and housing top part. According to the invention the housing top part and the housing bottom part are each made integrally from a creep-resistant material and have an overlapping region extending in an axial direction, wherein the cross-sectional shape of the housing top part and the housing bottom part is complementary at least in the overlapping region and the housing parts have an oversize relative to one another. The housing top and bottom parts are connected to each other by axial pressing forces with oversize loss in a media-tight manner.

Abstract: The invention relates to an assembly for use in automation and process measurement technology, comprising an at least two-part compact housing having a sleeve-shaped housing bottom part and housing top part. According to the invention the housing top part and the housing bottom part are each made integrally from a creep-resistant material and have an overlapping region extending in an axial direction, wherein the cross-sectional shape of the housing top part and the housing bottom part is complementary at least in the overlapping region and the housing parts have an oversize relative to one another. The housing top and bottom parts are connected to each other by axial pressing forces with oversize loss in a media-tight manner.

Abstract: A flow sensor for flowing media with a cylindrical housing (2) and with a sensor element located in the housing (2), the housing (2) preferably having an outside thread (3) and being screwable into a union (4) of a pipe (5) or into an opening of a connecting piece (43). The flow sensor (1) has very high measurement accuracy while still being economically producible. There is a lifting body (6) which projects into the flowing medium, the lifting body (6) being movably guided on the housing (2) and depending on the flow (7) of the medium to be monitored, can be moved against the reset force of a reset element which is located between the housing (2) and the lifting body (6), and the sensor element is made as a noncontact proximity switch (18, 20) which produces a signal that is dependent on the position of the lifting body (6).

Abstract: A flow sensor for flowing media with a cylindrical housing (2) and with a sensor element located in the housing (2), the housing (2) preferably having an outside thread (3) and being screwable into a union (4) of a pipe (5) or into an opening of a connecting piece (43). The flow sensor (1) has very high measurement accuracy while still being economically producible. There is a lifting body (6) which projects into the flowing medium, the lifting body (6) being movably guided on the housing (2) and depending on the flow (7) of the medium to be monitored, can be moved against the reset force of a reset element which is located between the housing (2) and the lifting body (6), and the sensor element is made as a noncontact proximity switch (18, 20) which produces a signal that is dependent on the position of the lifting body (6).

Abstract: Maleimide and succinimide derivatives were found to be effective topoisomerase II catalytic inhibitors. Due to this property, the maleimide and succinimide derivatives were investigated for their use as cytostatic agents and thus in the treatment of cancer. The compounds of the invention can be used in combination treatments with other cytostatic agents, such as topoisomerase II poisons. The maleimide and succinimide derivatives, due to their effective topoisomerase II catalytic inhibitory activity, are also useful as extravasation agents, such as upon administration of a topoisomerase II poison.

Abstract: A heat transfer monitoring and/or measuring device, especially a flow indicator for media flowing through a pipe (1), tank or fitting, with a sensor housing (2) and with two sensor elements (3, 4), the sensor elements (3, 4) each having a metallic sensor surface (5) which comes into contact with the flowing medium. In the flow indicator, the problem “deposition or formation” of disruptive layers on the sensor surfaces (5) of the sensor elements (3, 4) is solved by the element (3) which is made as a heating element having an electrically conductive protective lead (6) and by the protective lead (6) forming a closed protective circuit which includes the pipe (1), tank, or the fitting, the flowing medium and the sensor element (3).

Abstract: The present invention relates to a method for selectively killing tumor or metastatic cells within a defined compartment of the organism of a large mammal, in particular a human, said method comprising administering to a mammal an effective tumor—or metastasis-killing amount of a topoisomerase II poison except doxorubicin, and protecting non-tumorous tissue of the mammal against the toxic action of the topoisomerase II poison by administration of a bis-dioxypiperazine compound. In particular, the invention relates to a pharmaceutical kit for selectively killing tumor or metastatic cells within the central nervous system in a large mammal, in particular a human, said kit comprising: a) a dosage unit of a bis-dioxypiperazine and a pharmaceutically acceptable carrier, and b) a dosage unit of topoisomerase II poisons except doxorubicin and a pharmaceutically acceptable carrier.

Abstract: Disclosed in a heat transmission monitoring and/or measuring apparatus, namely a flow measurement apparatus, for flowing mediums. It comprises a housing (1), a heating element (2) and a temperature measurement element (3). According to the invention, relatively high sensititivity and relatively high reaction speed is obtained by designing the heating element (2) and temperature measurement element (3) as pins.

Abstract: A process for monitoring the flow of flowing media, especially for acquiring the heat transport capacity of the flowing medium, in which a measurement signal of a temperature measurement element influenced by at least one heating element and the medium flowing past it is monitored and in which an output signal is generated when the measurement signal of the temperature measurement element exceeds or falls below a switching point. A reduction of the reaction time of the process for monitoring the flow of flowing media is guaranteed by the heat output of the heating element and/or the location of the switching point changing as a function of the output signal.

Abstract: A screw-locking device has a stamped cup spring with a solid annular core having closely spaced triangular radial ribs top and bottom. The distance from the peaks of the ribs from the center plane of the core continually decreases from the outer rim of the annular spring towards the inner rim.