Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: The present application relates to the treatment of plant nematode infections. For example, the application relates to the use of one or more compounds of Formula (I) as defined herein, or compositions comprising these compounds, for treatment of a nematode infection or a disease, disorder or condition arising from a nematode infection in a plant in need thereof. Also included are novel compounds within the scope of Formula I and compositions and uses of these compounds for treatment of a nematode infection or a disease, disorder or condition arising from a nematode infection in a plant in need thereof.

Abstract: A water storage and filtering system for capturing pollutants from pollution borne storm water. The water storage and filtering system comprises a subsurface basin, at least one tire bundle made from a plurality of substantially whole tires secured sidewall to sidewall, and a filler which substantially fills the unoccupied volume of the subsurface basin. Pollutants in the storm water are captured as sediment in the subsurface basin as a result of the filtration and storage effects of the combination of the filler and tire bundles. The subsurface basin is covered by a water-permeable structure and multiple hollow vertical support columns may be included to support the expected load on the top of the basin.

Abstract: A water storage and filtering system for capturing pollutants from pollution borne storm water. The water storage and filtering system comprises a subsurface basin, at least one tire bundle made from a plurality of substantially whole tires secured sidewall to sidewall, and a filler which substantially fills the unoccupied volume of the subsurface basin. Pollutants in the storm water are captured as sediment in the subsurface basin as a result of the filtration and storage effects of the combination of the filler and tire bundles. The subsurface basin is covered by a water-permeable structure and multiple hollow vertical support columns may be included to support the expected load on the top of the basin.

Abstract: The present invention is a pediatric drain or tube management device. The device has a unitary swaddling device having a main portion, a first lateral portion adjacent to the main portion, a second lateral portion adjacent to the main portion and opposite the first lateral portion, and a covering portion. Each lateral portion has an aperture extending therethrough and an end having a fastening means affixed thereto. The covering portion is positioned exterior to the lateral portions and has a fastening means affixed thereto.

Abstract: An apparatus is provided for extending a data model. The apparatus may include at least one memory and at least one processor configured to provide information to a queue responsive to detection of new data associated with a user or an encounter or detection of modified data associated with the user or encounter. The processor is also configured to identify a pattern(s) based on analyzing the information in the queue. The information includes content of the new data or the modified data. The patterns include instructions specifying a calculation(s) for execution based on usage of the new data or the modified data. The processor is also configured to provide results of the calculation(s) to a database to enable access of the results by an application(s) or a communication device(s) responsive to executing a pattern(s) and determining the results of the calculation. Corresponding computer program products and methods are also provided.

Abstract: A snow ski, snow board and accessory storage device includes a backing plate; a hinge assembly carried by the backing plate, the hinge assembly including at least one hinge rotatable with respect to the backing plate; at least one backing arm carried by the at least one hinge of the hinge assembly, the at least one backing arm having an outer arm segment and an inner arm segment spaced-apart and parallel to the outer arm segment; the at least one backing arm adapted to receive a snow ski or snowboard between the outer arm segment and the inner arm segment; and a spreader and hanging bar carried by the backing plate, the at least one backing arm normally resting by gravity against the spreader and hanging bar and capable of being raised from the spreader and hanging bar as the at least one hinge rotates relative to the backing plate.

Abstract: An apparatus is provided for identifying patients of a cohort. The apparatus may include at least one memory and at least one processor configured to generate at least one user interface defining items of predefined criteria to identify a plurality of patients, among a candidate set of patients, of a cohort. The patients have at least one common characteristic associated with a designated medical condition or a designated health plan. The processor is also configured to identify the plurality of patients of the cohort in response to receiving indications of selections of one or more of the items of the predefined criteria. The processor is also configured to monitor and manage care of the identified patients of the cohort on an ongoing basis to provide interventions and track outcomes. Corresponding computer program products and methods are also provided.

Abstract: A container is partially filled with a raw cake batter. A lower portion of the container is covered by said batter and an upper portion of the container defines a void into which the cake batter can expand during baking The partially-filled container is frozen at the charging location. The container is then shipped under chilled conditions and presented for retail at said retail location in a chilled, substantially unfrozen state. The container is then purchased and placed directly into an oven without further preparation, in order to produce a freshly baked cake in said container.

Abstract: Disclosed are arrangements encode protection marks (302) into an unprotected document, where the protection marks are modulated according to a attributes of corresponding areas (902) of the unprotected document associated with the protection marks (302). Unauthorized amendment of the protected document can be detected by demodulating (1107) the modulated protection marks in the protected document, to derive the attribute of the unprotected document. This is compared to the corresponding attribute of the protected document, and this comparison indicates if unauthorized amendment has taken place.

Abstract: Disclosed are arrangements encode protection marks (302) into an unprotected document, where the protection marks are modulated according to a attributes of corresponding areas (902) of the unprotected document associated with the protection marks (302). Unauthorised amendment of the protected document can be detected by demodulating (1107) the modulated protection marks in the protected document, to derive the attribute of the unprotected document. This is compared to the corresponding attribute of the protected document, and this comparison indicates if unauthorised amendment has taken place.

Abstract: A surgical drill which includes a drill tip (3) rigidly secured to a shaft (2) for attachment of the drill to a rotary driving means, the end of the drill tip remote from the shaft being formed with cutting edges (4,5) tapering to a point (6), and the drill tip (3) having a cross-sectional shape such that the non-tapered portion of the drill tip (3) is substantially wider in a first direction (w) than in a second direction (x); the shaft (2) having a width at its widest point adjacent the drill tip (3) which is substantially smaller than the maximum cross-sectional width of the drill tip (3); the drill tip (3) being formed with at least one notch (8) for picking up a suture.

Abstract: Performance parameters of a switch may be ascertained by observing its behavior during a brief interval of high call volume. This may be achieved by accumulating call messages on a queue before allowing them to be processed together as a group. Without increasing the rate of incident calls, an accumulation of messages is accomplished by altering the amount of time that elapses between transferring the accumulation to a processing queue. In one implementation, test calls are accumulated in call input queue. Ordinarily, these calls are transferred to a second queue for processing every few milliseconds (the transfer period). By increasing the transfer period, an increased number of calls are stored in the call input queue before being transferred to the second queue. This allows a larger number of calls to be processed by the telephone switch in a given cycle and, hence, allows the switch's operation under increased call volumes to be observed.

Abstract: An implant useful as a prosthetic replacement of an intervertebral disk which consists of a housing providing at least a part simulation of a disk yet containing a force transferring media. The housing is in the form of a bellows or equivalent structure preferably restricted as to maximum separation between those surfaces of the housing to be in contact with the proximate vertebral bodies thereby to limit angular distortion under the effect of the proximate vertebral bodies.

Abstract: A method, and digital capture apparatus for use therewith, is described for correcting a channel dependent color aberration in a digital image, where the digital image is composed of a plurality of color channels. The method includes capturing an image comprising the color channels, where one of the color channels is a blurred color channel due to a channel dependent color aberration affecting that channel. Then, one of the other color channels, other than the blurred color channel, is used as an indication of an aim sharpness, and the sharpness of the blurred color channel is adjusted, at least partially, toward the aim sharpness.

Abstract: Ground anchors, in particular tent stakes (100), comprise one or more inherently flexible tines (110), a ground compression plate (160), and various tie points (420, etc.) for attaching a guy rope or the like to the top of anchor. The compression plate extends perpendicularly or at a large angle to the tine so that when the guy rope pulls on the anchor, the tine will tend to rotate about an underground fulcrum so that the compression plate will press against the ground and help the anchor resist pullout. The anchors are driven into the ground with a hammer or mallet. The tie points include hooks (420), closed holes (520), and swivel types comprising vertical members (810) with restraining, bulbous tops (820). An additional spring tie point (1600) can be inserted into optional lugs (1094, 1096) in the compression plate. The stakes can be driven into the ground vertically, or at an angle for additional holding force in some situations. They can also incorporate angled compression plates (160H, 160I).

Abstract: In an identification method, an analysis region in a test digital image is identified and values of a test parameter at a grid of locations in the analysis region are determined. A reference model of fixed pattern noise is associated with the test image. The reference model has an array of values of the test parameter for fixed pattern noise of a reference image acquisition device. A two or more dimensional similarity measure is calculated between the grid and at least a corresponding portion of the array.

Abstract: A mouthguard (10) of “C” shaped configuration having a forward portion (11) from which there rearwardly diverges a pair of arms (12). The mouthguard (10) in transverse cross section is of a “U” shaped configuration. In one embodiment each arm (12) is provided with a ridge (22) which acts as a shield, while the forward portion (11) is thickened so as to provide a labial shield (23).

Abstract: Ground anchors, in particular tent stakes (100), comprise one or more inherently flexible tines (110), a ground compression plate (160), and various tie points (420, etc.) for attaching a guy rope or the like to the top of anchor. The compression plate extends perpendicularly or at a large angle to the tine so that when the guy rope pulls on the anchor, the tine will tend to rotate about an underground fulcrum so that the compression plate will press against the ground and help the anchor resist pullout. The anchors are preferably driven into the ground with a hammer or mallet. The tie points include hooks (420), closed holes (520), and swivel types comprising vertical members (810) with restraining, bulbous tops (820). An additional spring tie point (1600) can be inserted into optional lugs (1094, 1096) in the compression plate. The stakes can be driven into the ground vertically, or at an angle for additional holding force in some situations. They can also incorporate angled compression plates (160H, 160I).

Abstract: A ground anchor for beach anchoring of vessels comprises three spaced parallel tines (10) pointed at one end and secured in spaced relationship at the other end by a mounting member (14, 24, 34). The mounting member includes one or more vertical or horizontal plates (16, 26, 40) and an optional stabilizer (28) which coact with the tines (10) to induce overlapping zones of compression in a sandy soil mass to reinforce the soil against movement of the anchor when horizontal tension is applied to it from a hawser attached to a moored vessel.