Abstract: The invention provides for bifunctional molecules comprising an Rpn11 binding partner and a target protein binding partner. A bifunctional molecule according to the invention binds to Rpn11 and to the target protein, thereby facilitating degradation of the target protein bound to the target protein binding partner. The invention also provides for use of a bifunctional molecule for preventing or treating disease.

Abstract: The invention provides for bifunctional molecules comprising an UchL5 binding partner and a target protein binding partner linked via a flexible linker. A bifunctional molecule according to the invention binds to UchL5 and to the target protein, thereby facilitating degradation of the target protein bound to the target protein binding partner. The invention also provides for use of a bifunctional molecule for preventing or treating disease.

Abstract: The invention provides for bifunctional molecules comprising an Rpn11 binding partner and a target protein binding partner. A bifunctional molecule according to the invention binds to Rpn11 and to the target protein, thereby facilitating degradation of the target protein bound to the target protein binding partner. The invention also provides for use of a bifunctional molecule for preventing or treating disease.

Abstract: A textile-based plate implant (and related methods) that supports tissue ingrowth within the implanted implant structure and is suitable for use in a variety of surgical applications, including but not limited to anterior, posterior and lateral surgical approaches directed towards the lumbar, thoracic and cervical regions of the spine.

Abstract: A combination pre-filled and in situ filled implant for the replacement of an intervertebral disc of the spine, including a textile core and a flange with apertures dimensioned to receive screws or other affixation elements. The combination pre-filled and in situ filled implant may also have attached side pockets comprised of extra layers of embroidered fabric. The pockets on the implant may serve a dual purpose: to facilitate insertion and to expand the dimensions of the implant after insertion.

Abstract: A manufacturing process and resultant medical devices and components thereof wherein one or more individual laces (12) is placed within an embroidered structure (10) using an automated process allowing for the manufacture of embroidered surgical implants containing laces to be mass produced repeatably and cost effectively.

Abstract: An embroidery process allowing for extra lengths of stitched thread pairs to be laid down in a zigzag pattern while embroidering on a dissolvable substrate such that when the substrate is removed, the extra length allows the two-dimensional embroidered structure to relax into a three-dimensional shape.

Abstract: An embroidery process allowing for a three-dimensional shape to be embroidered in two dimensions, allowing for the cost effective and repeatable manufacturing required for use in surgically implanted medical devices.

Abstract: Implants and methods aimed at safely repairing and/or reconstructing the facet joint so as to provide the required flexibility and elasticity to support continued motion after the implant has been implanted in a facet joint.

Abstract: A textile prosthesis comprising a unitary body of predetermined shape having structural integrity, the body including at least one anchorage body portion for attachment to an anatomical body part, the body being composed of a combination of binding yarns and tensile load bearing filaments, the binding yarns being located at least in the or in each of said anchorage body portions and being interconnected to one another by sewn stitches, the tensile load bearing filaments being located inbetween said stitches so as to be constrained to extend through said unitary body along predetermined pathways extending in one or more predetermined directions so as to render the body resistance to stretch when a tensile load is applied in said one or more predetermined directions.

Abstract: A clamshell package is provided including an enclosure configured to hold a product. The enclosure includes a recess configured to receive an alarm component of an alarm spider wrap.

Abstract: A textile-based surgical implant that can be inserted through any number of suitable surgical approaches, including but not limited to lateral, anterior, anterior-lateral, posterolateral, and/or posterior approaches. When applied to spine surgery and inserted into an intervertebral disc space, the implant restores the normal height of the intervertebral disc space, while advantageously preserving the natural motion of the spine. The textile construction of the implant is beneficial because it is generally compliant and thereby restores and/or improves spinal motion. The compliant nature of the textile-based implant provides the required flexibility and elasticity to advantageously support physiological movements, as opposed to fusion surgery which forms a boney bridge between adjacent vertebral bodies.

Abstract: A textile prosthesis comprising a unitary body of predetermined shape having structural integrity, the body including at least one anchorage body portion for attachment to an anatomical body part, the body being composed of a combination of binding yarns and tensile load bearing filaments, the binding yarns being located at least in the or in each of said anchorage body portions and being interconnected to one another by sewn stitches, the tensile load bearing filaments being located in between said stitches so as to be constrained to extend through said unitary body along predetermined pathways extending in one or more predetermined directions so as to render the body resistance to stretch when a tensile load is applied in said one or more predetermined directions.

Abstract: A method of assembling a prefabricated speaker enclosure and an assembly including left and right side panels, top, front, bottom, and rear panels each having an inner surface with a left channel configured to receive the left side panel and a right channel configured to receive the right, side panel, and a continuous material extending along an outer surface of the top, front, bottom, and rear panels to form a living hinge at each point where two of the top, front, bottom, and rear panels meet.

Abstract: A manufacturing process and resultant medical devices and components thereof wherein one or more individual laces (12) is placed within an embroidered structure (10) using an automated process allowing for the manufacture of embroidered surgical implants containing laces to be mass produced repeatably and cost effectively.

Abstract: An adapter for installing an aftermarket audio device in a vehicle. The adapter includes a first and second connectors electrically connected together, the first connector being suitable for connecting to a wiring harness in the vehicle and the second connector being unsuitable for connection to the wiring harness in the vehicle, the second connector being further suitable for connection in a different wiring harness in a different vehicle. The adapter also includes a plurality of wires electrically connected to the first and second connectors, the wires being adapted to connect to the aftermarket audio device.

Abstract: A textile-based plate implant (and related methods) that supports tissue ingrowth within the implanted implant structure and is suitable for use in a variety of surgical applications, including but not limited to anterior, posterior and lateral surgical approaches directed towards the lumbar, thoracic and cervical regions of the spine.

Abstract: A textile prosthesis comprising a unitary body of predetermined shape having structural integrity, the body including at least one anchorage body portion for attachment to an anatomical body part, the body being composed of a combination of binding yarns and tensile load bearing filaments, the binding yarns being located at least in the or in each of said anchorage body portions and being interconnected to one another by sewn stitches, the tensile load bearing filaments being located inbetween said stitches so as to be constrained to extend through said unitary body along predetermined pathways extending in one or more predetermined directions so as to render the body resistance to stretch when a tensile load is applied in said one or more predetermined directions.

Abstract: An embroidery process allowing for extra lengths of stitched thread pairs to be laid down in a zigzag pattern while embroidering on a dissolvable substrate such that when the substrate is removed, the extra length allows the two-dimensional embroidered structure to relax into a three-dimensional shape.

Abstract: An embroidery process allowing for a three-dimensional shape to be embroidered in two dimensions, allowing for the cost effective and repeatable manufacturing required for use in surgically implanted medical devices.