Abstract: A composition includes Purified Exosome Product (PEP) and a pharmaceutically acceptable carrier that includes a surgical glue or tissue adhesive. In some embodiments, the PEP includes spherical or spheroid exosomes having a diameter no greater than 300 nm. In some embodiments, the PEP includes from 1% to 20% CD63? exosomes and from 80% to 99% CD63+ exosomes. In some embodiments, the PEP includes at least 50% CD63? exosomes. The composition may be applied to injured peripheral nervous tissue to promote growth of peripheral nervous tissue and/or treat the injured peripheral nervous tissue. The peripheral nervous tissue may be autologous or may be allogeneic.

Abstract: Method and system for non-invasive determination of a pressure characteristic associated with carpal tunnel (CT) region of a subject. Speed of a shear wave induced in the tissue of the subject and propagating through the CT region is measured at least once. The pressure characteristic is substantially proportional to determined speed.

Abstract: This document relates to methods and materials involved in tendon or ligament tissue engineering. For example, methods and materials for generating a composite of acellular tendon or ligament allograft slices seeded with cells and bundled into a graft for tissue repair are provided.

Abstract: A system and method is provided for using dynamic ultrasonic imaging to analyze a subject's carpal tunnel and generate risk factors indicative of the health of the subject's subsynovial connective tissue and the subject's risk of developing carpal tunnel syndrome. The system and method uses speckle imaging techniques to track dynamic structures within the carpal tunnel and statistical analysis techniques to compare the properties of these dynamic structures of the subject to those of normal subjects and subjects having carpal tunnel syndrome.

Abstract: Method and system for non-invasive determination of a pressure characteristic associated with carpal tunnel (CT) region of a subject. Speed of a shear wave induced in the tissue of the subject and propagating through the CT region is measured at least once. The pressure characteristic is substantially proportional to determined speed.

Abstract: This disclosure describes methods for detecting early stages of disease, in particular carpal tunnel syndrome, by using cooperative ultrasound techniques. In a particular embodiment, a grayscale ultrasonogram may be used to detect local anatomical features within the carpal tunnel by physically moving a tendon and identifying the corresponding feature on the ultrasonogram display device. A high-resolution color Doppler ultrasound device may then be used to interrogate features of anatomy surrounding the tendon for disease. In a particular embodiment, the color Doppler ultrasound device may be used to measure the velocities of the tendon and surrounding anatomy, in particular the sub-synovial connective tissue; the resultant data may be used to quantify certain anatomical anomalies, indicative or non-indicative of carpal tunnel syndrome.

Abstract: This document relates to methods and materials for treating tendon injury. Specifically, methods and materials for preventing adhesion formation and promoting tissue healing following tendon injury and surgical repair are provided.

Abstract: This document relates to methods and materials involved in tendon or ligament tissue engineering. For example, methods and materials for generating a composite of acellular tendon or ligament allograft slices seeded with cells and bundled into a graft for tissue repair are provided.

Abstract: A system and method is provided for using dynamic ultrasonic imaging to analyze a subject's carpal tunnel and generate risk factors indicative of the health of the subject's subsynovial connective tissue and the subject's risk of developing carpal tunnel syndrome. The system and method uses speckle imaging techniques to track dynamic structures within the carpal tunnel and statistical analysis techniques to compare the properties of these dynamic structures of the subject to those of normal subjects and subjects having carpal tunnel syndrome.

Abstract: The invention relates to a method of strengthening a tissue against the force of a suture by forming a reinforced eyelet in the tissue. Such an eyelet can be formed by any means that results in strengthening or reinforcement of a tissue against the tensile force of a suture. A reinforced eyelet can be formed via the physical attachment of a strengthening means to a tissue or by contacting a tissue with an eyelet-forming agent. Also described are sutures and kits for use with the method of reinforcing a tissue by forming a reinforced eyelet.