Patents by Inventor Peter C. Chua

Peter C. Chua has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • KRAS INHIBITORS
    Publication number: 20260224589
    Abstract: The present embodiments provide compounds of Formula (I), compositions of the compounds, and methods for treating diseases such as cancer.
    Type: Application
    Filed: February 16, 2024
    Publication date: August 6, 2026
    Inventors: Nicholas A. Isley, Jun Feng, Jean-Michel Vernier, Marcos Gonzalez-Lopez, Peter C. Chua, Ping Chen, Adriana Irimia, Hengmiao Cheng, Takasuke Mukaiyama, Lucas Nguyen
  • PYRROLIDINE-FUSED HETEROCYCLES
    Publication number: 20210292330
    Abstract: A compound of Formula (I) is provided: where the variables are defined herein.
    Type: Application
    Filed: February 26, 2021
    Publication date: September 23, 2021
    Inventors: Takasuke Mukaiyama, Peter C. Chua, Jean-Michel Vernier
  • Fused tricyclic compounds as serine-threonine protein kinase and PARP modulators
    Patent number: 9062043
    Abstract: The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, modulating protein kinase activity and modulating polymerase activity. Molecules of the invention can modulate casein kinase (CK) activity and/or poly(ADP-ribose)polymerase (PARP) activity. The invention also relates in part to methods for using such molecules.
    Type: Grant
    Filed: February 25, 2011
    Date of Patent: June 23, 2015
    Assignee: SENHWA BIOSCIENCES, INC.
    Inventors: Peter C. Chua, Fabrice Pierre, Jeffrey P. Whitten
  • PROTEIN KINASE MODULATORS
    Publication number: 20120208792
    Abstract: The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, modulating protein kinase activity and modulating polymerase activity. Molecules of the invention can modulate Pim kinase activity and/or FMS-like tyrosine kinase (Flt) activity. The invention also relates in part to methods for using such molecules.
    Type: Application
    Filed: December 8, 2011
    Publication date: August 16, 2012
    Applicant: CYLENE PHARMACEUTICALS, INC.
    Inventors: Peter C. Chua, Mustapha Haddach, Johnny Y. Nagasawa, Fabrice Pierre, Jeffrey P. Whitten
  • Protein kinase modulators
    Patent number: 8168651
    Abstract: The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, modulating protein kinase activity and modulating polymerase activity. Molecules of the invention can modulate Pim kinase activity and/or FMS-like tyrosine kinase (Flt) activity. The invention also relates in part to methods for using such molecules.
    Type: Grant
    Filed: March 2, 2009
    Date of Patent: May 1, 2012
    Assignee: Cylene Pharmaceuticals, Inc.
    Inventors: Peter C. Chua, Mustapha Haddach, Johnny Y. Nagasawa, Fabrice Pierre, Jeffrey P. Whitten
  • FUSED TRICYCLIC COMPOUNDS AS SERINE-THREONINE PROTEIN KINASE AND PARP MODULATORS
    Publication number: 20110263581
    Abstract: The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, modulating protein kinase activity and modulating polymerase activity. Molecules of the invention can modulate casein kinase (CK) activity and/or poly(ADP-ribose)polymerase (PARP) activity. The invention also relates in part to methods for using such molecules.
    Type: Application
    Filed: February 25, 2011
    Publication date: October 27, 2011
    Applicant: CYLENE PHARMACEUTICALS, INC.
    Inventors: Peter C. CHUA, Fabrice Pierre, Jeffrey P. Whitten
  • Inhibitors of Akt activity
    Patent number: 8003643
    Abstract: The present invention is directed to compounds which contain substituted pyridazines and pyrimidines moieties which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.
    Type: Grant
    Filed: November 18, 2009
    Date of Patent: August 23, 2011
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Mark T. Bilodeau, Peter C. Chua, Nicholas D. P. Cosford, Jacob M. Hoffman, Johnny Yasuo Nagasawa
  • Fused tricyclic compounds as serine-threonine protein kinase and PARP modulators
    Patent number: 7956064
    Abstract: The invention relates in part to fused tricyclic compounds having certain biological activities that include, but are not limited to, inhibiting cell proliferation, modulating protein kinase activity and modulating polymerase activity. The fused tricyclic compounds of the invention can modulate casein kinase (CK) activity and/or poly(ADP-ribose)polymerase (PARP) activity. The invention also relates in part to methods for using such fused tricyclic compounds.
    Type: Grant
    Filed: August 31, 2007
    Date of Patent: June 7, 2011
    Assignee: Cylene Pharmaceuticals, Inc.
    Inventors: Peter C. Chua, Jeffrey P. Whitten
  • NOVEL PROTEIN KINASE MODULATORS
    Publication number: 20100298302
    Abstract: The invention provides compounds that inhibit selected kinases (Pim, Flt and/or CK2 kinases) and compositions containing such compounds. These compounds and compositions are useful for treating proliferative disorders such as cancer, as well as other kinase-associated conditions including inflammation, pain, and certain infections and immunological disorders.
    Type: Application
    Filed: May 20, 2010
    Publication date: November 25, 2010
    Inventors: Fabrice PIERRE, Mustapha Haddach, Peter C. Chua
  • Methods of preparing quinolone analogs
    Patent number: 7834180
    Abstract: Compounds having formula 1: are produced by contacting a compound having formula (6A) with a compound having formula (7), or tautomers thereof, in the presence of a non-nucleophilic base, wherein V, A, Z, L, L1, W, X, B?, R and n are as defined herein.
    Type: Grant
    Filed: November 19, 2008
    Date of Patent: November 16, 2010
    Assignee: Cylene Pharmaceuticals, Inc.
    Inventors: Peter C. Chua, Johnny Y. Nagasawa, Michael Schwaebe, Fabrice Pierre
  • Methods of preparing quinolone analogs
    Patent number: 7816524
    Abstract: Compounds having formula 1 are produced by contacting a compound having formula(6A) with a compound having formula (7), or tautomers thereof, in the presence of a non-nucleophilic base, wherein V, A, Z, L, L1,W, X, B?, R and N are as defined herein.
    Type: Grant
    Filed: August 4, 2006
    Date of Patent: October 19, 2010
    Assignee: Cylene Pharmaceuticals, Inc.
    Inventors: Peter C. Chua, Johnny Y. Nagasawa, Michael Schwaebe, Fabrice Pierre
  • INHIBITORS OF AKT ACTIVITY
    Publication number: 20100075970
    Abstract: The present invention is directed to compounds which contain substituted pyridazines and pyrimidines moieties which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.
    Type: Application
    Filed: November 18, 2009
    Publication date: March 25, 2010
    Inventors: Mark T. Bilodeau, Peter C. Chua, Nicholas D.P. Cosford, Jacob M. Hoffman, Johnny Yasou Nagasawa
  • Inhibitors of Akt activity
    Patent number: 7655649
    Abstract: The present invention is directed to compounds which contain substituted pyridazines and pyrimidines moieties which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.
    Type: Grant
    Filed: April 5, 2005
    Date of Patent: February 2, 2010
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Mark T. Bilodeau, Peter C. Chua, Nicholas D. P. Cosford, Jacob M. Hoffman, Johnny Yasuo Nagasawa
  • PROTEIN KINASE MODULATORS
    Publication number: 20090239859
    Abstract: The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, modulating protein kinase activity and modulating polymerase activity. Molecules of the invention can modulate Pim kinase activity and/or FMS-like tyrosine kinase (Flt) activity. The invention also relates in part to methods for using such molecules.
    Type: Application
    Filed: March 2, 2009
    Publication date: September 24, 2009
    Inventors: Peter C. CHUA, Mustapha Haddach, Johnny Y. Nagasawa, Fabrice Pierre, Jeffrey P. Whitten
  • SERINE-THREONINE PROTEIN KINASE AND PARP MODULATORS
    Publication number: 20090105233
    Abstract: The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, modulating protein kinase activity and modulating polymerase activity. Molecules of the invention can modulate casein kinase (CK) activity and/or poly(ADP-ribose)polymerase (PARP) activity. The invention also relates in part to methods for using such molecules.
    Type: Application
    Filed: August 31, 2007
    Publication date: April 23, 2009
    Inventors: Peter C. CHUA, Fabrice Pierre, Jeffrey P. Whitten
  • METHODS OF PREPARING QUINOLONE ANALOGS
    Publication number: 20090082565
    Abstract: The present invention relates to the preparation of compounds which are capable of inducing cell death such as apoptotic cell death (apoptosis), and/or for reducing a cell proliferative disorder.
    Type: Application
    Filed: November 19, 2008
    Publication date: March 26, 2009
    Applicant: Cylene Pharmaceuticals, Inc.
    Inventors: Peter C. CHUA, Johnny Y. Nagasawa, Michael Schwaebe, Fabrice Pierre
  • Inhibitors of Akt Activity
    Publication number: 20080280889
    Abstract: The present invention is directed to compounds which contain substituted pyridazines and pyrimidines moieties which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration (if the compounds of the invention.
    Type: Application
    Filed: April 5, 2005
    Publication date: November 13, 2008
    Inventors: Mark T. Bilodeau, Peter C. Chua, Nicholas D.P. Cosford, Jacob M. Hoffman, Johnny Yasuo Nagasawa