Abstract: One embodiment provides a neurorestoration compound or composition implementing multiple neuroplasticity inducing mechanisms of action including a mixture of pharmacologically effective amounts of Cilostazol and Metformin and Telmisartan. A second embodiment provides a neurorestoration compound or composition implementing multiple neuroplasticity inducing mechanisms of action including a mixture of pharmacologically effective amounts of Cilostazol and Metformin and Duloxetine. The neurorestoration compound implementing multiple neuroplasticity inducing mechanisms of action is believed to be particularly well suited for stroke rehabilitation.

Abstract: A pharmacotherapeutic protocol enhancing neuro-restoration in the human brain for patients suffering with brain injuries and diseases, wherein the protocol comprises treating the patient with a combinatorial pharmacological composition comprising a pharmacologically effective amount of a first Neuroplasticity PA therapeutic agent exhibiting a mechanism of plasticity in at least one of Neurogenesis, Synaptogenesis, Remyelination, Angiogenesis, Bioenergetics, Inflammation and Apoptosis, and a pharmacologically effective amount of a second Neuroplasticity PA therapeutic agent exhibiting a mechanism of plasticity in at least one of Neurogenesis, Synaptogenesis, Remyelination, Angiogenesis, Bioenergetics, Inflammation and Apoptosis; wherein the mechanism of plasticity of the first Neuroplasticity PA therapeutic agent differs from the mechanism of plasticity of the second Neuroplasticity PA therapeutic agent. Combinatorial pharmacological composition are also disclosed.

Abstract: A stroke rehabilitation protocol comprising the steps of: providing a subject with medicaments including at least one of Cilostazol, Metformin, Telmisartan and Duloxetine; and implementing robotic assisted rehabilitation in the subject with pharmacologically induced neuroplasticity, wherein the medicaments are supplied in effective amounts and timing whereby the medicaments induce neuroplasticity during the robotic assisted rehabilitation. The stroke rehabilitation protocol includes multiple robotic assisted rehabilitation sessions and the medicaments are orally administered to the patient within 4 hours implementing of each robotic assisted rehabilitation session. The multiple robotic assisted rehabilitation sessions may be on an upper limb robot with 500-700 repetitions per session which sessions total at least 10 hours.