Patents by Inventor Peter C Isakson

Peter C Isakson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Therapeutic combinations for cardiovascular and inflammatory indications
    Publication number: 20040186154
    Abstract: The present invention provides therapeutic combinations and methods for treating or preventing a hypercholesterolemia-related or an inflammation-related condition in a subject in need of such treatment or prevention. One therapeutic combination comprises an ASBT inhibitor combined with COX-2 inhibitor. A further therapeutic combination comprises an ASBT inhibitor, a COX-2 inhibitor and an HMG Co-A reductase inhibitor. Another therapeutic combination comprises a chromene COX-2 inhibitor and an HMG Co-A reductase inhibitor.
    Type: Application
    Filed: May 6, 2004
    Publication date: September 23, 2004
    Inventors: Karen Seibert, Bradley T Keller, Peter C Isakson
  • Immunosuppressive effects of administration of a cyclooxygenase-2 inhibitor, a leukotriene B4 receptor inhibitor and a cyclosporin
    Patent number: 6617345
    Abstract: Treatment with a cyclooxygenase-2 inhibitor and a leukotriene B4 receptor antagonist is described as being useful in reducing recipient rejection of transplanted organs and for treatment of autoimmune diseases.
    Type: Grant
    Filed: September 12, 2000
    Date of Patent: September 9, 2003
    Assignee: G.D. Searle & Co.
    Inventors: Susan A Gregory, Peter C Isakson, Gary Anderson
  • Immunosuppressive effects of administration of a cyclooxygenase-2 inhibitor and a leukotriene A4 hydrolase inhibitor
    Patent number: 6407140
    Abstract: Treatment with a cyclooxygenase-2 inhibitor and a leukotriene A4 hydrolase inhibitor is described as being useful in reducing recipient rejection of transplanted organs and for treatment of autoimmnune diseases.
    Type: Grant
    Filed: January 21, 2000
    Date of Patent: June 18, 2002
    Assignee: G.D. Searle & Co.
    Inventors: Susan A Gregory, Peter C Isakson, Gary Anderson
  • Immunosuppressive effects of administration of a cyclooxygenase-2 inhibitor and a 5-lipoxygenase inhibitor
    Patent number: 6376528
    Abstract: A method to suppress immune, acute or delayed-type hypersensitivity by treatment with a combination of a therapeutically-effective amount of a 5-lipoxygenase inhibitor and a cyclooxygenase-2 inhibitor is reported. The method may be used, for example, to suppress the immune response associated with organ transplantation, graft versus host disease, and conditions with underlying autoimmune or inflammatory reactivities or responses.
    Type: Grant
    Filed: October 18, 1999
    Date of Patent: April 23, 2002
    Assignee: G. D. Searle & Co.
    Inventors: Susan A Gregory, Peter C Isakson, Gary Anderson
  • Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitors and a leukotriene B4 receptor antagonist
    Patent number: 6342510
    Abstract: Combinations of a cyclooxygenase-2 inhibitor and a leukotriene B4 receptor antagonist are described for treatment of inflammation and inflammation-related disorders.
    Type: Grant
    Filed: June 11, 1996
    Date of Patent: January 29, 2002
    Assignee: G. D. Searle & Co.
    Inventors: Peter C Isakson, Gary D Anderson, Susan A Gregory
  • Immunosuppressive effects of administration of a cyclooxygenase-2 inhibitor and a leukotriene B4 receptor antagonist
    Patent number: 6172096
    Abstract: Treatment with a cyclooxygenase-2 inhibitor and a leukotriene B4 receptor antagonist is described as being useful in reducing recipient rejection of transplanted organs and for treatment of autoimmune diseases.
    Type: Grant
    Filed: May 11, 1998
    Date of Patent: January 9, 2001
    Assignee: G. D. Searle & Co.
    Inventors: Susan A Gregory, Peter C Isakson, Gary Anderson
  • Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitor and a 5-lipoxygenase inhibitor
    Patent number: 6136839
    Abstract: Combinations of a cyclooxygenase-2 inhibitor and a 5-lipoxygenase inhibitor are described for treatment of inflammation and inflammation-related disorders.
    Type: Grant
    Filed: June 11, 1996
    Date of Patent: October 24, 2000
    Assignee: G. D. Searle & Co.
    Inventors: Peter C Isakson, Gary D Anderson, Susan A Gregory
  • Method of detecting cyclooxygenase-2
    Patent number: 6045773
    Abstract: The invention relates to a method of detecting concentrations of cyclooxygenase-2 in a mammal, the method comprising: administering to the mammal a diagnostically effective amount of a cyclooxygenase-2 selective agent, which is capable of being detected in vivo; and b) detecting the agent so the concentration of cyclooxygenase-2 is detected.
    Type: Grant
    Filed: February 24, 1999
    Date of Patent: April 4, 2000
    Assignee: G.D. Searle & Co.
    Inventors: Peter C Isakson, Karen Seibert, John J Talley