Patents by Inventor Peter C. Meltzer
Peter C. Meltzer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10399994Abstract: Disclosed herein are compounds, and pharmaceutical compositions that include such compounds, for preventing or treating hearing loss. The compounds and pharmaceutical compositions described herein prevent or treat hair cell death. In addition, the compounds and pharmaceutical compositions described herein protect against kidney damage in an individual receiving an aminoglycoside antibiotic. Methods of using the compounds, alone or in combination with other therapeutic agents, are also disclosed.Type: GrantFiled: February 5, 2016Date of Patent: September 3, 2019Assignees: University of Washington, Oricula Therapeutics LLC, Fred Hutchinson Cancer Research CenterInventors: Julian Simon, Graham Johnson, Edwin W. Rubel, David W. Raible, Mario D. Gonzalez, Peter C. Meltzer, Weishi Miao
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Publication number: 20180022756Abstract: Disclosed herein are compounds, and pharmaceutical compositions that include such compounds, for preventing or treating hearing loss. The compounds and pharmaceutical compositions described herein prevent or treat hair cell death. In addition, the compounds and pharmaceutical compositions described herein protect against kidney damage in an individual receiving an aminoglycoside antibiotic. Methods of using the compounds, alone or in combination with other therapeutic agents, are also disclosed.Type: ApplicationFiled: February 5, 2016Publication date: January 25, 2018Inventors: Julian Simon, Graham Johnson, Edwin W. Rubel, David W. Raible, Mario D. Gonzalez, Peter C. Meltzer, Weishi Miao
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Patent number: 9493482Abstract: Disclosed herein are compounds, and pharmaceutical compositions that include such compounds, for preventing or treating hearing loss. The compounds and pharmaceutical compositions described herein prevent or treat hair cell death. In addition, the compounds and pharmaceutical compositions described herein protect against kidney damage in an individual receiving an aminoglycoside antibiotic. Methods of using the compounds, alone or in combination with other therapeutic agents, are also disclosed.Type: GrantFiled: February 5, 2016Date of Patent: November 15, 2016Assignees: University of Washington, Oricula Therapeutics LLC, Fred Hutchinson Cancer Research CenterInventors: Julian Simon, Graham Johnson, Edwin Rubel, David Raible, Mario D. Gonzalez, Peter C. Meltzer, Weishi Miao
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Publication number: 20160229869Abstract: Disclosed herein are compounds, and pharmaceutical compositions that include such compounds, for preventing or treating hearing loss. The compounds and pharmaceutical compositions described herein prevent or treat hair cell death. In addition, the compounds and pharmaceutical compositions described herein protect against kidney damage in an individual receiving an aminoglycoside antibiotic. Methods of using the compounds, alone or in combination with other therapeutic agents, are also disclosed.Type: ApplicationFiled: February 5, 2016Publication date: August 11, 2016Inventors: Julian SIMON, Graham JOHNSON, Edwin RUBEL, David RAIBLE, Mario D. GONZALEZ, Peter C. MELTZER, Weishi MIAO
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Publication number: 20100143248Abstract: A method of diagnosing attention deficient-hyperactivity disorder (ADHD) in a human patient by assessing the level of dopamine transporter in at least one region of the patient's central nervous system, where an elevated level of dopamine transporter in the patient is indicative of ADHD. In embodiments of the invention, assessment of dopamine transporter levels includes assessing binding of a dopamine transporter ligand to the dopamine transporters using PET or SPECT.Type: ApplicationFiled: June 23, 2009Publication date: June 10, 2010Applicants: President and Fellows of Harvard College, Organix, Inc., The General Hospital CorporationInventors: Bertha K. Madras, Alan J. Fischman, Peter C. Meltzer
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Publication number: 20090270626Abstract: The invention provides compounds and methods for preparing radiopharmaceutical compounds useful as therapeutic and diagnostic agents.Type: ApplicationFiled: March 12, 2009Publication date: October 29, 2009Applicant: Organix, Inc.Inventor: Peter C. Meltzer
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Publication number: 20090208415Abstract: The present invention provides novel tropane compounds and methods for their use.Type: ApplicationFiled: December 11, 2008Publication date: August 20, 2009Applicants: President and Fellows of Harvard College, Organix, Inc.Inventors: Paul Blundell, Peter C. Meltzer, Bertha K. Madras
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Patent number: 7553478Abstract: A method of diagnosing attention deficient-hyperactivity disorder (ADHD) in a human patient by assessing the level of dopamine transporter in at least one region of the patient's central nervous system, where an elevated level of dopamine transporter in the patient is indicative of ADHD. In embodiments of the invention, assessment of dopamine transporter levels includes assessing binding of a dopamine transporter ligand to the dopamine transporters using PET or SPECT.Type: GrantFiled: July 18, 2006Date of Patent: June 30, 2009Assignees: President and Fellows of Harvard College, Organix, Inc.Inventors: Bertha K. Madras, Alan J. Fischman, Peter C. Meltzer
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Publication number: 20090048284Abstract: This invention to antagonists that inhibit transporters and receptors. The invention also relates to partial inhibitors of transporters and receptors that allow partial transport or partial binding of a compound to the transporter or receptor. The invention also relates to compounds that differentially prevent transport or binding through a transporter or to a receptor. The invention also relates to the use of these compounds for treating certain diseases and disorders.Type: ApplicationFiled: October 21, 2008Publication date: February 19, 2009Inventors: Peter C. Meltzer, Bertha K. Madras, Paul Blundell, Shanghao Liu
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Patent number: 7476740Abstract: The present invention provides novel tropane compounds and methods for their use.Type: GrantFiled: March 27, 2003Date of Patent: January 13, 2009Assignees: President and Fellows of Harvard College, Organix, Inc.Inventors: Paul Blundell, Peter C. Meltzer, Bertha K. Madras
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Patent number: 7439264Abstract: This invention to antagonists that inhibit transporters and receptors. The invention also relates to partial inhibitors of transporters and receptors that allow partial transport or partial binding of a compound to the transporter or receptor. The invention also relates to compounds that differentially prevent transport or binding through a transporter or to a receptor. The invention also relates to the use of these compounds for treating certain diseases and disorders.Type: GrantFiled: February 10, 2003Date of Patent: October 21, 2008Assignees: President and Fellows of Harvard College, Organix, Inc.Inventors: Peter C. Meltzer, Bertha K. Madras, Paul Blundell, Shanghao Liu
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Publication number: 20080234498Abstract: New compounds that bind to monoamine transporters are described. The compounds of the present invention can be racemic or pure R— or S-enantiomers. Certain preferred compounds of the present invention have a high selectively dopamine transporter versus the serotonin transporter. Preferred monoamine transporters for the practice of the present invention include the dopamine transporter, the serotonin transporter and the norepinephrine transporter.Type: ApplicationFiled: October 8, 2004Publication date: September 25, 2008Applicants: PRESIDENT AND FELLOW OF HARVARD COLLEGE, ORGANIX, INC.Inventors: David Butler, Bertha K. Madras, Peter C. Meltzer
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Patent number: 7199132Abstract: New tropane analogs that bind to monoamine transporters are described, particularly, 8-aza, 8carbo and 8-oxo tropanes having 6- or 7-hydroxyl or ketone substituents. The compounds of the present invention can be racemic, pure R-enantiomers, or pure S-enantiomers. Certain preferred compounds of the present invention have a high selectivity for the DAT versus the SERT. Also described are pharmaceutical therapeutic compositions comprising the compounds formulated in a pharmaceutically acceptable carrier and a method for inhibiting 5-hydroxy-tryptamine reuptake of a monoamine transporter by contacting the monoamine transporter with a 5-hydroxytryptamine reuptake inhibiting amount of a compound of the present invention. Preferred monoamine transporters for the practice of the present invention include the dopamine transporter, the serotonin transporter and the norepinephrine transporter.Type: GrantFiled: December 27, 2001Date of Patent: April 3, 2007Assignees: Organix, Inc., President and Fellows of Harvard CollegeInventors: Peter C. Meltzer, Bertha K. Madras, Paul Blundell
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Patent number: 7105678Abstract: Radiopharmaceutical compounds are disclosed. A tropane compound is linked through the N atom at the 8-position to a chelating ligand capable of complexing technetium or rhenium to produce a neutral labeled complex that selectively binds to the dopamine transporter over the serotonin transporter with a ratio of 10 or more. These compounds can be prepared as separate diastereoisomers as well as a mixture of diastereoisomers. Also disclosed are radiopharmaceutical kits for preparing the labeled radiopharmaceutical compounds.Type: GrantFiled: October 11, 2001Date of Patent: September 12, 2006Assignees: Organix, Inc., President and Fellows of Harvard College, The General Hospital CorporationInventors: Peter C. Meltzer, Paul Blundell, Bertha C. Madras
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Patent number: 7081238Abstract: A method of diagnosing attention deficient-hyperactivity disorder (ADHD) in a human patient by assessing the level of dopamine transporter in at least one region of the patient's central nervous system, where an elevated level of dopamine transporter in the patient is indicative of ADHD. In embodiments of the invention, assessment of dopamine transporter levels includes assessing binding of a dopamine transporter ligand to the dopamine transporters using PET or SPECT.Type: GrantFiled: August 17, 2001Date of Patent: July 25, 2006Assignees: The President and Fellows of Harvard College, The General Hospital Corporation, Organix, Inc.Inventors: Bertha K. Madras, Alan J. Fischman, Peter C. Meltzer
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Patent number: 7026516Abstract: Featured compounds have high monoamine transport affinity and are characterized by one of the following two general formulas set out above. The compounds bind selectively or non-selectively to monoamine transporters. The compounds are useful to treat various medical indications including attention deficit hyperactivity disorder (ADHD), Parkinson's disease, cocaine addiction, smoking cessation, weight reduction, obsessive-compulsive disorder, various forms of depression, traumatic brain injury, stroke, and narcolepsy.Type: GrantFiled: February 24, 2003Date of Patent: April 11, 2006Assignees: President and Fellows of Harvard College, Organix, Inc.Inventors: Peter C. Meltzer, Paul Blundell, Pinglang Wang, Bertha K. Madras
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Publication number: 20040014992Abstract: Featured compounds have high monoamine transport affinity and are characterized by one of the following two general formulas set out above. The compounds bind selectively or non-selectively to monoamine transporters. The compounds are useful to treat various medical indications including attention deficit hyperactivity disorder (ADHD), Parkinson's disease, cocaine addiction, smoking cessation, weight reduction, obsessive-compulsive disorder, various forms of depression, traumatic brain injury, stroke, and narcolepsy.Type: ApplicationFiled: February 24, 2003Publication date: January 22, 2004Inventors: Peter C. Meltzer, Paul Blundell, Pinglang Wang, Bertha K. Madras
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Patent number: 6677338Abstract: The present invention relates to the therapeutic use of non-amine tropane analogues that bind to the SERT to treat neuropsychiatric disorders.Type: GrantFiled: February 28, 2002Date of Patent: January 13, 2004Assignees: President and Fellows of Harvard College, Organix, Inc.Inventors: Bertha K. Madras, Peter C. Meltzer
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Patent number: 6670375Abstract: New tropane analogs that bind to monoamine transporters are described, particularly, 8-aza, 8carbo and 8-oxo tropanes having 6- or 7-substituents. The compounds of the present invention can be racemic, pure R-enantiomers, or pure S-enantiomers. Certain preferred compounds of the present invention have a high selectivity for the DAT versus the SERT. Also described are pharmaceutical therapeutic compositions comprising the compounds formulated in a pharmaceutically acceptable carrier and a method for inhibiting 5-hydroxy-tryptamine reuptake of a monoamine transporter by contacting the monoamine transporter with a 5-hydroxytryptamine reuptake inhibiting amount of a compound of the present invention. Preferred monoamine transporters for the practice of the present invention include the dopamine transporter, the serotonin transporter and the norepinephrine transporter.Type: GrantFiled: June 6, 2001Date of Patent: December 30, 2003Assignees: Organix, Inc., President and Fellows of Harvard CollegeInventors: Peter C. Meltzer, Bertha K. Madras, Paul Blundell, Zhengming Chen
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Publication number: 20030232827Abstract: This invention to antagonists that inhibit transporters and receptors. The invention also relates to partial inhibitors of transporters and receptors that allow partial transport or partial binding of a compound to the transporter or receptor. The invention also relates to compounds that differentially prevent transport or binding through a transporter or to a receptor. The invention also relates to the use of these compounds for treating certain diseases and disorders.Type: ApplicationFiled: February 10, 2003Publication date: December 18, 2003Inventors: Peter C. Meltzer, Bertha K. Madras, Paul Blundell, Shanghao Lui