Abstract: Compounds of the following formula and their acid addition salts ##STR1## Z is ##STR2## A is straight or branched chain alkylene of 2 to 6 carbons; B is straight chain alkylene of 2 to 4 carbons; X is straight or branched chain alkyl of 1 to 8 carbons, phenyl, benzyl, phenethyl, substituted phenyl, substituted benzyl, or substituted phenethyl, R.sub.1 and R.sub.2 are located at the 7 or 8 and 5 or 6 position respectively and are independently selected from the group consisting of hydrogen, straight or branched chain alkyl of 1 to 4 carbons, straight or branched chain alkoxy of 1 to 4 carbons, Cl, Br, F, amino, nitro, CF.sub.3, and cyano; are disclosed. These compounds possess antiprotozoal activity.

Abstract: Compounds of the following formula and their acid addition salts ##STR1## A is straight or branched chain alkylene of 2 to 6 carbons; R.sub.1 and R.sub.2 are located at the 7 or 8 and 5 or 6 position respectively and are independently selected from the group consisting of hydrogen, straight or branched chain alkyl of 1 to 4 carbons, straight or branched chain alkoxy of 1 to 4 carbons, Cl, Br, F, amino, nitro, cyano, and CF.sub.3 ; R.sub.3 and R.sub.4 are independently selected from the group consisting of hydrogen and straight or branched chain alkyl of 1 to 4 carbons; and n is 1, 2, or 3; m is 1 or 2; are disclosed. These compounds possess anti-protozoal activity.

Abstract: Compounds of the following formula ##STR1## wherein R.sup.1 and R.sup.2 are independently selected from hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio, nitro, cyano, and trifluoromethyl, and R is selected from a triacetyl substituted pentose, pentose, a tetraacetyl substituted hexose, hexose, a hydroxy substituted cycloalkyl of 5 to 7 carbons, ##STR2## wherein n is 1 or 2 and R.sup.3 is hydrogen, an alkali metal or alkaline earth metal ion; are disclosed. These compounds possess useful anti-inflammatory activity.

Abstract: Compounds having the formula ##STR1## wherein A is a straight or branched chain alkylene group; R is hydrogen, halogen, alkyl, alkoxy, alkylthio, trifluoromethyl, nitro, amino, or cyano; and m is 2, 3 or 4; are useful in the treatment of allergic conditions in mammals.

Abstract: Compounds having the structure ##STR1## wherein R.sub.1 is hydrogen, alkyl, phenyl, or benzyl; R.sub.2 is hydrogen or alkyl; R.sub.3 is hydrogen, alkyl, haloalkyl, cyanoalkyl, trifluoromethyl, phenyl, benzyl, ##STR2## OR --(CH.sub.2).sub.n --NR.sub.5 R.sub.6 ; R.sub.4 is hydrogen, halogen, nitro, cyano, trifluoromethyl, alkyl, alkoxy, or alkylthio; R.sub.5 and R.sub.6 are the same or different and are hydrogen or alkyl or R.sub.5 and R.sub.6 together with the nitrogen atom to which they are attached form a five or six membered heterocyclic ring; and n is 1, 2, 3 or 4; are useful as anti-inflammatory agents.

Abstract: Compounds of the following formula and their pharmaceutically acceptable salts ##STR1## wherein R.sub.1 and R.sub.4 are the same or different and are each a five or six membered N containing heterocycle attached at an available N atom; R.sub.2 is hydrogen, alkyl, trifluoromethyl, phenyl, benzyl, --(CH.sub.2).sub.n --R.sub.4 or --(CH.sub.2).sub.n --N(alkyl).sub.2 ; R.sub.3 is hydrogen, halogen, nitro, trifluoromethyl, alkyl, alkoxy, or alkylthio; and n is an integer from 1 to 4; are disclosed. These compounds are useful as anti-inflammatory agents.

Abstract: Compounds having the formula ##STR1## wherein A is a straight or branched chain alkylene group; R.sub.1 is hydrogen, halogen, alkyl, alkoxy, alkylthio, trifluoromethyl, nitro, amino, or cyano; and n is 0, 1, or 2; are useful central nervous system depressants.

Abstract: Compounds of the following formula ##STR1## wherein R.sup.1 and R.sup.2 are selected from hydrogen, lower alkyl, lower alkoxy, lower alkylthio, halogen, trifluoromethyl, nitro, amino and cyano; Z is selected from ##STR2## R.sup.3 is selected from phenyl, phenyl-lower alkyl, substituted phenyl, and substituted phenyl-lower alkyl; R.sup.4 is selected from R.sup.3 and a 6-membered unsaturated substituted or unsubstituted heterocyclic ring selected from pyridine, diazine and triazine; and A is a straight or branched chain alkylene of 2 to 8 carbons are disclosed. These compounds exhibit antidepressant activity.

Abstract: Method of treating allergies with a pharmaceutical composition containing as the active ingredient a compound or mixture of compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 are independently selected from hydrogen, halogen, trifluoromethyl, lower alkyl, lower alkoxy, lower alkylthio, nitro, amino, or cyano; and A is a straight or branched chain alkylene of 1 to 8 carbons.

Abstract: Compounds of the following formula and their acid addition salts ##STR1## wherein R.sup.1 and R.sup.2 are selected from hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio, nitro, amino, trifluoromethyl, or cyano; R.sup.3 is hydrogen or lower alkyl; R.sup.4 and R.sup.5 are selected from hydrogen, halogen, lower alkyl, or lower alkoxy; the dashed line indicates the optional presence of a double bond; and A is straight or branched chain alkylene of 1-8 carbons; are disclosed. These compounds exhibit antidepressant activity. In addition, these compounds are useful as antiinflammatory agents.

Abstract: Compounds of the following formula and their acid addition salts ##STR1## wherein R.sup.1 and R.sup.2 are selected from hydrogen, lower alkyl, lower alkoxy, lower alkylthio, halogen, trifluoromethyl, amino, nitro and cyano; R.sup.3 is hydrogen, lower alkyl or lower alkenyl; R.sup.4 is hydrogen, halogen, or lower alkyl; and A is straight or branched chain alkylene are disclosed. These compounds exhibit antidepressant activity. In addition, these compounds are useful as antiinflammatory agents.

Abstract: Compounds which are useful as anti-inflammatory agents have the formula ##SPC1##Wherein X, Y, Y' and Z are as defined herein.

Abstract: Compounds having the formula ##SPC1##Wherein A is a straight or branched chain alkylene group; R.sub.1 is hydrogen, halogen, alkyl, alkoxy, alkylthio, nitro, amino, or cyano; and R.sub.2 is hydrogen, halogen, alkyl, alkoxy, trifluoromethyl, nitro, amino, or cyano; and n is 1 or 2, with the proviso that when n is 2, R.sub.1 is alkyl, alkoxy, or halogen; are useful central nervous system depressants.

Abstract: Triazolo[4,3-d][1,4]benzodiazepine-3,6-diones having in the 2-position an alkyl, phenyl or arylalkyl substituent are useful anti-inflammatory agents.

Abstract: Compounds of the following formula and their pharmaceutically acceptable salts ##SPC1##Wherein R.sub.1 and R.sub.4 are the same or different and are each a five or six membered N containing heterocycle attached at an available N atom; R.sub.2 is hydrogen, alkyl, trifluoromethyl, phenyl, benzyl, --(CH.sub.2).sub.n --R.sub.4 or --(CH.sub.2).sub.n --N(alkyl).sub.2 ; R.sub.3 is hydrogen, halogen, nitro, trifluoromethyl, alkyl, alkoxy, or alkylthio; and n is an integer from 1 to 4; are disclosed. These compounds are useful as anti-inflammatory agents.

Abstract: Compounds of the following formula and their acid addition salts ##SPC1##Wherein R.sup.1 and R.sup.2 are independently selected from hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio, nitro, cyano, amino and trifluoromethyl; A is a straight or branched chain alkylene of 1 to 8 carbons; R.sup.3 is phenyl or substituted phenyl; and R is lower alkyl or cycloalkyl of 3 to 7 carbons are disclosed. These compounds exhibit antidepressant activity. In addition these compounds are useful as antiinflammatory agents.

Abstract: Compounds of the following formula and their acid addition salts ##SPC1##Wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are independently selected from hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio, nitro, cyano, amino and trifluoromethyl; A is a straight or branched chain alkylene of 1 to 8 carbons; and m is 1 or 2 are disclosed. These compounds exhibit antidepressant and anti-anxiety activity. In addition these compounds are useful as antiinflammatory agents.

Abstract: Compounds of the structure ##SPC1##Are provided which are useful as anti-inflammatory agents.Compounds having the structure ##SPC2##Wherein R is lower alkyl, phenyl, or benzyl and X is hydrogen, halogen, nitro, trifluoromethyl, alkyl, alkoxy or alkylthio, are useful as anti-inflammatory agents.The term "alkyl", as used throughout the specification, either by itself or as part of a larger group, refers to both straight and branched chain alkyl groups containing 1, 2, 3 or 4 carbon atoms.The term "alkoxy", as used throughout the specification, refers to a group of the formula Y--O--, wherein Y is alkyl as defined above.The term "halogen", as used throughout the specification, refers to fluorine, chlorine, bromine, and iodine.Preferred are those compounds wherein R is alkyl and X is hydrogen or halogen; most preferred are those compounds wherein R is methyl and X is 5-Cl.The compounds of formula I are useful in the treatment of inflammatory conditions in mammalian speices, e.g., rats, dogs, cats, monkeys, etc.

Abstract: Compounds of the following formula and their acid addition salts ##SPC1##Wherein R.sup.1 and R.sup.2 are independently selected from hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio, nitro, cyano, amino and trifluoromethyl; A is a straight or branched chain alkylene of 1 to 8 carbons; and Z is ##SPC2##Wherein R.sup.3 is selected from phenyl, phenyl-lower alkyl, and substituted phenyl and phenyl-lower alkyl are disclosed. These compounds exhibit antidepressant activity. In addition these compounds are useful as antiinflammatory agents.

Abstract: Compounds of the following formula and their acid addition salts ##SPC1##Wherein R.sup.1 and R.sup.2 are independently selected from hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio, nitro, cyano, amino and trifluoromethyl; A is a straight or branched chain alkylene of 1 to 8 carbons; and R is a 6-membered unsaturated substituted or unsubstituted heterocyclic ring selected from pyridine, diazine and triazine are disclosed. These compounds exhibit antidepressant activity. In addition these compounds are also useful as antiinflammatory agents.