Abstract: A mass spectrometer comprising: a vacuum housing comprising a first vacuum chamber having a first gas exhaust port; a gas pump (1700) having a first gas inlet port connected to the first gas exhaust port (H1) by a first gas conduit for evacuating the first vacuum chamber, and a first apertured cover (2010) arranged over the first gas exhaust port (H1) or first gas inlet port, or in the first gas conduit therebetween.

Abstract: A mass spectrometer comprising: a vacuum housing comprising a first vacuum chamber having a first gas exhaust port; a gas pump (1700) having a first gas inlet port connected to the first gas exhaust port (H1) by a first gas conduit for evacuating the first vacuum chamber; and a first apertured cover (2010) arranged over the first gas exhaust port (H1) or first gas inlet port, or in the first gas conduit therebetween.

Abstract: A mass spectrometer comprising: a vacuum chamber; and an ion inlet assembly for transmitting analyte ions into the vacuum chamber; wherein the spectrometer is configured to operate in a cooling mode in which it selectively controls one or more gas flow to the ion inlet assembly for actively cooling the ion inlet assembly.

Abstract: A mass spectrometer is disclosed comprising an ion optics device housing having one or more external electrical connectors (1719) provided thereon. An ion optics device (301) is arranged inside the ion optics device housing, the ion optics device (301) comprising one or more electrodes for manipulating ions, the one or more electrodes being electrically connected to the one or more external electrical connectors (1719) provided on the ion optics device housing. A voltage supply housing (1717) is provided having one or more external electrical connectors provided thereon. One or more voltage supplies are arranged inside the voltage supply housing (1717), the one or more voltage supplies being in electrical communication with the one or more external electrical connectors provided on the voltage supply housing.

Abstract: A mass spectrometer includes a control system arranged to assess an operational state of the mass spectrometer. When a fault is detected, the control system assigns the fault to one of a plurality of categories, including a first category of faults which may be attempted to be rectified automatically by the mass spectrometer, a second category of faults which may be attempted to be rectified by the user, and a third category of faults which may only be attempted to be rectified by a service engineer. When a fault is assigned to the first category of faults, the control system initiates an attempt to automatically rectify the fault. When a fault is assigned to the second category of faults, the control system causes information relating to the fault to be displayed to the user, including data indicative of the fault and data one or more steps to be taken by the user to attempt to rectify the fault (2000).

Abstract: An assembly for a mass spectrometer, comprising a housing (106) and a Time of Flight analyser (110), wherein the housing (106) is configured to enclose at least the Time of Flight analyser (110), and the Time of Flight analyser comprises a pusher assembly (120) and a flight tube (160), wherein the Time of Flight mass analyser (110) is cantilevered from the housing.

Abstract: A mass spectrometer is disclosed comprising an ion optics device housing having one or more external electrical connectors (1719) provided thereon. An ion optics device (301) is arranged inside the ion optics device housing, the ion optics device (301) comprising one or more electrodes for manipulating ions, the one or more electrodes being electrically connected to the one or more external electrical connectors (1719) provided on the ion optics device housing. A voltage supply housing (1717) is provided having one or more external electrical connectors provided thereon. One or more voltage supplies are arranged inside the voltage supply housing (1717), the one or more voltage supplies being in electrical communication with the one or more external electrical connectors provided on the voltage supply housing.

Abstract: A mass spectrometer includes a control system arranged to assess an operational state of the mass spectrometer. When a fault is detected, the control system assigns the fault to one of a plurality of categories, including a first category of faults which may be attempted to be rectified automatically by the mass spectrometer, a second category of faults which may be attempted to be rectified by the user, and a third category of faults which may only be attempted to be rectified by a service engineer. When a fault is assigned to the first category of faults, the control system initiates an attempt to automatically rectify the fault. When a fault is assigned to the second category of faults, the control system causes information relating to the fault to be displayed to the user, including data indicative of the fault and data one or more steps to be taken by the user to attempt to rectify the fault (2000).

Abstract: A mass spectrometer comprising: a vacuum chamber; and an ion inlet assembly for transmitting analyte ions into the vacuum chamber; wherein the spectrometer is configured to operate in a cooling mode in which it selectively controls one or more gas flow to the ion inlet assembly for actively cooling the ion inlet assembly.

Abstract: A mass spectrometer comprising: a vacuum housing comprising a first vacuum chamber having a first gas exhaust port; a gas pump (1700) having a first gas inlet port connected to the first gas exhaust port (H1) by a first gas conduit for evacuating the first vacuum chamber; and a first apertured cover (2010) arranged over the first gas exhaust port (H1) or first gas inlet port, or in the first gas conduit therebetween.

Abstract: An assembly for a mass spectrometer, comprising a housing (106) and a Time of Flight analyser (110), wherein the housing (106) is configured to enclose at least the Time of Flight analyser (110), and the Time of Flight analyser comprises a pusher assembly (120) and a flight tube (160), wherein the Time of Flight mass analyser (110) is cantilevered from the housing.

Abstract: A Time of Flight analyser comprising a flight tube (160) and a reflectron (170), wherein the reflectron comprises a stack of electrodes (172) that are compressed against the flight tube such that they remain parallel to each other under compression.

Abstract: Disclosed herein is a bench-top time of flight mass spectrometer. In embodiments, there is provided a solvent bottle mounting assembly configured so that a user can press a solvent bottle onto the solvent bottle mounting assembly in order to mount the solvent bottle to the mass spectrometer. Other embodiments relate to a vacuum arrangement comprising first and second vacuum chambers with respective first and second vacuum pumps wherein a backing line for the second vacuum pump is connected to the first vacuum chamber such that the second vacuum pump is backed to the first vacuum chamber. Also disclosed in a method of manufacturing a lens plate or electrode wherein a substrate is chemically etched to reduce a sharp cusp to provide a smoother edge profile.

Abstract: A purification column is provided in which fluid is purified by flow through a purifying component. The column includes an annular wall defining a bore which, in use, contains the purifying component. The column further includes an inlet port to the bore comprising a first aperture through the annular wall, the inlet port being adjacent one end of the column. The column further includes an outlet port from the bore comprising a second aperture through the annular wall, the outlet port being adjacent the same end of the column as the inlet port. The column further includes a flow guidance device within the bore and removably connected to the inlet and outlet ports for guiding the fluid to the purifying component from the inlet port and for guiding the fluid from the purifying component to the outlet port. The flow guidance device maintains separation of the fluid flows to and from the purifying component.

Abstract: A purification column is provided in which fluid is purified by flow through a purifying component. The column includes an annular wall defining a bore which, in use, contains the purifying component. The column further includes an inlet port to the bore comprising a first aperture through the annular wall, the inlet port being adjacent one end of the column. The column further includes an outlet port from the bore comprising a second aperture through the annular wall, the outlet port being adjacent the same end of the column as the inlet port. The column further includes a flow guidance device within the bore and removably connected to the inlet and outlet ports for guiding the fluid to the purifying component from the inlet port and for guiding the fluid from the purifying component to the outlet port. The flow guidance device maintains separation of the fluid flows to and from the purifying component.

Abstract: A filter assembly for collecting material entrained in a fluid stream includes a filter element having a tubular filter and an end cap providing a flow conduit which extends between first and second conduit openings communicating with the internal void of the tubular filter. A housing for the filter element has inlet and outlet ports for the fluid stream, a housing bowl in which the tubular filter is located, and a housing head which provides at least one of the ports as a docking port for the first conduit opening. The housing head and end cap are arranged such that the end cap is inserted into the housing head, and then rotated relative to the housing head about an axis perpendicular to the axis of the tubular filter and to the axis of the first conduit.