Abstract: A well plate stimulator includes a lid configured to be coupled to a well plate comprising a plurality of wells. The well plate stimulator also includes a plurality of pairs of well conductors. Each of the pairs is configured to be inserted into a different one of the wells in the well plate when the well plate stimulator is coupled to the well plate. Each of the pairs includes a first well conductor that is coupled to a first wire and a second well conductor that is coupled to a second wire. Positive and negative portions of a signal generate an electrical current between the first and second well conductors in each pair to stimulate cells within the wells. The well conductors have an electrical conductivity that is greater than about 8×106 S/m.

Abstract: One aspect of the invention provides a sample chamber for use in the dynamic imaging of cells. In one embodiment, the chamber includes a holding mechanism for positioning the cells against a viewing window in the chamber. A housing is positioned against the viewing window to define the closed chamber. The housing may include access ports allowing for the perfusion of fluid through the chamber, the control of the internal temperature of the chamber and the micromanipulation and electrical stimulation of the cells.

Abstract: One aspect of the invention provides a sample chamber for use in the dynamic imaging of cells. In one embodiment, the chamber includes a holding mechanism for positioning the cells against a viewing window in the chamber. A housing is positioned against the viewing window to define the closed chamber. The housing may include access ports allowing for the perfusion of fluid through the chamber, the control of the internal temperature of the chamber and the micromanipulation and electrical stimulation of the cells.