Patents by Inventor Peter Castric

Peter Castric has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for eliciting an immune response to gram-negative bacterial infections
    Patent number: 7132101
    Abstract: Compositions for eliciting an immune response against Gram-negative bacterial infections and methods of making such compositions are provided. The composition comprises glycosylated pilin, the pilin being glycosylated with the O-antigen of a target Gram-negative bacteria of interest. Methods of eliciting an immune response by administration of such compositions are also provided.
    Type: Grant
    Filed: February 27, 2002
    Date of Patent: November 7, 2006
    Assignee: Duquesne University of the Holy Ghost
    Inventor: Peter A. Castric
  • Compositions and methods for eliciting an immune response to gram-negative bacterial infections
    Publication number: 20060057700
    Abstract: Compositions for eliciting an immune response against Gram-negative bacterial infections and methods of making such compositions are provided. The composition comprises glycosylated pilin, the pilin being glycosylated with the O-antigen of a target Gram-negative bacteria of interest. Methods of eliciting an immune response by administration of such compositions are also provided.
    Type: Application
    Filed: July 29, 2005
    Publication date: March 16, 2006
    Inventor: Peter Castric
  • Conjugate vaccine against gram-negative bacterial infections
    Patent number: 6872398
    Abstract: The present invention relates to a broadly reactive vaccine against Gram-negative bacteria which is composed of a biological glycan-pilus conjugate. The conjugate core is a common pilus type to which is attached the glycan of choice in vivo. Pooling of these bioconjugates produces a multivalent vaccine. These pili give high bronchial titers when delivered by the intranasal route. Mice vaccinated with pure glycosylated P. aeruginosa strain 1244 pili in this manner are protected against respiratory challenge with P. aeruginosa strain 1244. The present invention further relates to a DNA and amino acid sequence of a new gene, pilO, which is capable of glycosylating pilin of Gram-negative bacteria and uses thereof.
    Type: Grant
    Filed: June 23, 1999
    Date of Patent: March 29, 2005
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Peter Castric, Alan S. Cross, Jerald C. Sadoff
  • Compositions and methods for eliciting an immune response to Gram-negative bacterial infections
    Publication number: 20040248241
    Abstract: Compositions for eliciting an immune response against Gram-negative bacterial infections and methods of making such compositions are provided. The composition comprises glycosylated pilin, the pilin being glycosylated with the O-antigen of a target Gram-negative bacteria of interest. Methods of eliciting an immune response by administration of such compositions are also provided.
    Type: Application
    Filed: February 27, 2002
    Publication date: December 9, 2004
    Inventor: Peter A. Castric
  • CONJUGATE VACCINE AGAINST GRAM-NEGATIVE BACTERIAL INFECTIONS
    Publication number: 20020039755
    Abstract: The present invention relates to a broadly reactive vaccine against Gram-negative bacteria which is composed of a biological glycan-pilus conjugate. The conjugate core is a common pilus type to which is attached the glycan of choice in vivo. Pooling of these bioconjugates produces a multivalent vaccine. These pili give high bronchial titers when delivered by the intranasal route. Mice vaccinated with pure glycosylated P. aeruginosa strain 1244 pili in this manner are protected against respiratory challenge with P. aeruginosa strain 1244. The present invention further relates to a DNA and amino acid sequence of a new gene, pilO, which is capable of glycosylating pilin of Gram-negative bacteria and uses thereof.
    Type: Application
    Filed: June 23, 1999
    Publication date: April 4, 2002
    Applicant: VENABLE BAETJER HOWARD & CIVILETTI, LLP
    Inventors: PETER CASTRIC, ALAN S. CROSS, JERALD C. SADOFF