Abstract: A microfluidic test system is disclosed. The system includes a test substrate including parallel channels and reaction chambers. The reaction chambers are adapted to accommodate optical transmittance, absorbance and reflectance testing. The movement of the fluid within the system is controlled and synchronized in real time with the optical measurements of the reagents and analytes within each individual reaction chamber. The optical testing of each reaction chamber is customized regarding the color and intensity of the source light. The system includes an easy-to-use applicator for the capture of the test fluid and a fully automated measurement and test system. The microfluidic test system may be incorporated into clothing or apparel such as in a diaper. A device and method are also disclosed.

Abstract: A method is described for the certification by a control unit of map elements for safety-critical driving functions. At least one observation variable of at least one mapping step of at least one map element is ascertained after an implementation of the mapping step via a monitoring function and is compared with a setpoint value of the observation variable. At least one result value is calculated based on a comparison of the observation variable with the setpoint value of the observation variable for the at least one mapping step via the monitoring function. The at least one result value is stored as a certificate and is linked to the at least one map element. A control unit, a computer program and a machine-readable memory medium are also described.

Abstract: Provided herein are antisense oligonucleotides (AONs) that induce skipping of exon 51 of human dystrophin pre-mRNA, and pharmaceutically acceptable derivatives thereof. Also provided are pharmaceutical compositions containing the AONs and methods of using the AONs and compositions for treating a subject with Duchenne muscular dystrophy.

Abstract: The current invention provides antisense splice-switching oligonucleotides with improved characteristics that enhance clinical applicability for treating, ameliorating, preventing, and/or delaying neuromuscular disorders, such as DMD.

Abstract: The embodiments disclose a method including capturing video footage of a youth sports event using at least one video camera with a mobile application installed, transmitting to at least one network server with internet and WI-FI connectivity mobile application multi-camera live-streaming video camera captured game footage, recording on at least one database coupled to the network server at least one video camera mobile application multi-camera live-streaming video camera captured game footage, using at least one network computer coupled to at least one network server configured for processing and displaying multi-camera live-streaming video camera captured game footage for live video streaming game broadcast on a plurality of subscribed viewer digital devices, and mixing advertising into the processed multi-camera live-streaming video camera captured game footage broadcast using the at least one network computer.

Abstract: A system for executing software, wherein a computing device stores first software instructions for a code execution module such that, when the first software instructions are executed, the computing device will: receive, for execution by the code execution module, second software instructions; create one or more immutable software nodes described in the second software instructions; determine that the second software instructions comprise an instruction to begin a simulated change at runtime of the one or more immutable software nodes; store the simulated change in a simulated change apparatus; using the simulated change apparatus, perform one or more operations of the second software instructions as if the one or more immutable software nodes had been changed in memory, during a period of time where each of the one or more immutable software nodes is guaranteed to retain logical immutability; and output results of the one or more operations.

Abstract: A microfluidic test system is disclosed. The system includes a test substrate including parallel channels and reaction chambers. The reaction chambers are adapted to accommodate optical transmittance, absorbance and reflectance testing. The movement of the fluid within the system is controlled and synchronized in real time with the optical measurements of the reagents and analytes within each individual reaction chamber. The optical testing of each reaction chamber is customized regarding the color and intensity of the source light. The system includes an easy-to-use applicator for the capture of the test fluid and a fully automated measurement and test system. The microfluidic test system may be incorporated into clothing or apparel such as in a diaper. A device and method are also disclosed.

Abstract: The embodiments disclose a method including capturing video footage of a youth sports event using at least one video camera with a mobile application installed, transmitting to at least one network server with internet and WI-FI connectivity mobile application multi-camera live-streaming video camera captured game footage, recording on at least one database coupled to the network server at least one video camera mobile application multi-camera live-streaming video camera captured game footage, using at least one network computer coupled to at least one network server configured for processing and displaying multi-camera live-streaming video camera captured game footage for live video streaming game broadcast on a plurality of subscribed viewer digital devices, and mixing advertising into the processed multi-camera live-streaming video camera captured game footage broadcast using the at least one network computer.

Abstract: According to aspects of the present disclosure, there are provided methods and apparatus for providing a user characteristics determination module for use with a head-mountable display device, comprising: a biological characteristics handler to determine whether biological sensor data is indicative of a predefined biological characteristic of the user; and determination logic to determine and output a predefined response to the determined biological characteristic of the user.

Abstract: An enclosure or housing for an air monitoring instrument package for mounting on the roof or other surface on the outside of vehicles such as cars, trucks, buses, trams, trains and ships. By measuring air pollutants from moving vehicles, it is possible to explore the distribution of air pollutants throughout a city or rural area for the identification of sources of different pollutants, estimating human exposures to air pollutants, and mapping air pollutants with high resolution. The disclosed device provides continuous sampling of outside air while simultaneously protecting the delicate instruments from weather elements such as high wind, rain, snow, sleet and hail. The design also allows a nearly constant flow rate of sampled air independent of vehicle velocity. An optional impaction region further reduces transmission of mist and large particles to the chamber containing the measurement package.

Abstract: The invention regards a method for electrochemical ammonia synthesis, comprising the steps of: providing at least one electrolysis cell; contacting the cathode with a source of lithium cations, nitrogen, and protons; and subjecting the cathode to a continuous pulsed cathode potential, including a pulsed cathodic current load, wherein the cathode potential is pulsed between the lithium reduction potential and a less negative cathode potential, whereby ammonia is synthesized.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer-storage media, for selective heating. In some implementations, a cooking device for selective heating includes a cavity, one or more waveguides coupled to the cavity, a power generation means coupled to the one or more waveguides and configured to generate an incident power, one or more apertures between the cavity and the one or more waveguides, and a controller configured to control one or more of the power generation means, the apertures, or a cavity geometry. A cooking device cavity geometry can be dynamically configurable. The cooking device can include one or more sensors coupled to the cavity.

Abstract: The embodiments disclose a method including capturing video footage of a youth sports event using at least one video camera with a mobile application installed, transmitting to at least one network server with internet and WI-FI connectivity mobile application multi-camera live-streaming video camera captured game footage, recording on at least one database coupled to the network server at least one video camera mobile application multi-camera live-streaming video camera captured game footage, using at least one network computer coupled to at least one network server configured for processing and displaying multi-camera live-streaming video camera captured game footage for live video streaming game broadcast on a plurality of subscribed viewer digital devices, and mixing advertising into the processed multi-camera live-streaming video camera captured game footage broadcast using the at least one network computer.

Abstract: The current invention provides an improved oligonucleotide and its use for treating, ameliorating, preventing, delaying and/or treating a human cis-element repeat instability associated genetic neuromuscular or neurodegenerative disorder.

Abstract: A playground apparatus has a first platform assembly, a second platform assembly, and a pole structure. The first platform assembly includes a first platform structure disposed at a distance from the surface. The second platform assembly is disposed spaced apart from the first platform assembly. The second platform assembly includes a second platform structure disposed at a distance from the surface. Further, the pole structure is disposed between the first platform assembly and the second platform assembly, and includes a lever portion having at least one support structure for supporting one or more child.

Abstract: Walkers capable of adapting to surrounding environments, including stairs, curbs, sidewalks, and other surface or ground obstacles that have adjacent uneven surfaces. The walkers include a frame assembly having back legs, front legs, and a handlebar fixedly coupled to the back legs. Intermediate members respectively couple the front legs to the back legs and are configured for selective vertical adjustment of vertical positions of the front legs relative to the back legs and relative to at least a first surface engaged by lower ends of the back legs. After selective vertical adjustment of the vertical positions of the front legs, the front and back legs of the walker are capable of engaging and supporting the walker on the first surface engaged by the lower ends of the back legs and engaging and supporting the walker on at least a second surface engaged by lower ends of the front legs.

Abstract: Apparatus for cutting off extrudate produced with an extruder having a die with at least one opening includes a knife which is mounted rotatably about an axis of rotation and which can be driven by a drive, in particular an electric motor, in that a torque is transmitted from the drive to the knife. A bearing element is provided which can be rigidly connected to the extruder and via which the knife can be rotatably connected to the extruder around the axis of rotation, whereby the drive can be placed separately from the bearing element and a magnetic coupling is provided between the bearing element and the drive in order to transmit the torque from the drive to the knife via magnetic forces.

Abstract: A method and a system for mapping a surroundings of at least one vehicle and for locating the at least one vehicle. Measurement data of the vehicle's surroundings are ascertained by at least one radar sensor of the at least one vehicle, the measurement data of the at least one radar sensor being aggregated. The aggregated measurement data are compared with already existing aggregated measurement data. The aggregated measurement data are optimized by reducing measurement errors based on the comparison between the aggregated measurement data and the already existing aggregated measurement data. A map is generated or updated on the basis of the optimized aggregated measurement data, and the at least one vehicle being located on the generated or updated map by comparing the ascertained measurement data with the generated map.

Abstract: The embodiments disclose a method including capturing video footage of a youth sports event using at least one video camera with a mobile application installed, transmitting to at least one network server with internet and WI-FI connectivity mobile application multi-camera live-streaming video camera captured game footage, recording on at least one database coupled to the network server at least one video camera mobile application multi-camera live-streaming video camera captured game footage, using at least one network computer coupled to at least one network server configured for processing and displaying multi-camera live-streaming video camera captured game footage for live video streaming game broadcast on a plurality of subscribed viewer digital devices, and mixing advertising into the processed multi-camera live-streaming video camera captured game footage broadcast using the at least one network computer.

Abstract: A new cultivar of Forsythia plant named ‘UMNFOR01’ that is characterized by its heavy flower production in spring, its moderate growth rate and short internodes resulting in a dense, compact, and rounded plant shape, its small stature; reaching a mature height of about 1.52 m and a mature spread of about 1.82 m, and its flower buds that are hardy to U.S.D.A. Zone 5a and plant hardiness to U.S.D.A. Zone 4a.