Patents by Inventor Peter Cicala

Peter Cicala has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMIDAZO [2,1-B] QUINAZOLIN-2-ONE DERIVATIVES AND THEIR USE AS PLATELET ANTI-AGGREGATIVE AGENTS
    Publication number: 20110152298
    Abstract: This invention relates to the discovery of substituted analogues of the selective platelet lowering agent anagrelide with reduced potential for cardiovascular side-effects which should lead to improved patient compliance and safety in the treatment of myeloproliferative diseases. More specifically, the present invention relates to certain imidazoquinazoline derivatives which have the general formula shown below where the substituents have the meanings defined in claim (I) and which have utility as platelet lowering agents in humans. The compounds of the present invention function by inhibiting megakaryocytopoeisis and hence the formation of blood platelets.
    Type: Application
    Filed: May 13, 2009
    Publication date: June 23, 2011
    Applicant: SHIRE LLC
    Inventors: Bernard T. Golding, Richard Franklin, Angus Macleod, Peter Cicala
  • SUBSTITUTED QUINAZOLINES
    Publication number: 20110130413
    Abstract: This invention relates to the discovery of prodrugs of substituted analogues of the selective platelet lowering agent anagrelide which have reduced potential for cardiovascular side-effects and which should therefore lead to improved patient compliance and safety in the treatment of myeloproliferative diseases. More specifically, the present invention relates to prodrugs of certain imidazoquinazoline derivatives which have the general formula (I) shown below wherein the substituents have the meanings defined in claim 1 and which have utility as platelet lowering agents in humans. The compounds of the present invention function by inhibiting the formation of blood platelets.
    Type: Application
    Filed: May 13, 2009
    Publication date: June 2, 2011
    Applicant: Shire LLC
    Inventors: Bernard Golding, Peter Cicala, Richard Franklin, Angus Macleod
  • SUBSTITUTED QUINAZOLINES
    Publication number: 20110065714
    Abstract: This invention relates to the discovery of 3-and 5-substituted analogues of the selective platelet lowering agent anagrelide with reduced potential for cardiovascular side-effects which should lead to improved patient compliance and safety in the treatment of myeloproliferative diseases. More specifically, the present invention relates to certain imidazoquinazoline derivatives which have the general formula shown below wherein the substituents have the meanings defined in claim 1: and which have utility as platelet lowering agents in humans. The compounds of the present invention function by inhibiting megakaryocytopoeisis and hence the formation of blood platelets.
    Type: Application
    Filed: May 13, 2009
    Publication date: March 17, 2011
    Applicant: Shire LLC
    Inventors: Bernard Golding, Peter Cicala, Richard Franklin, Kim Hirst
  • SUBSTITUTED QUINAZOLINES
    Publication number: 20110065735
    Abstract: This invention relates to the discovery of substituted analogues of the selective platelet lowering agent anagrelide with reduced potential for cardiovascular side-effects which should lead to improved patient compliance and safety in the treatment of myeloproliferative diseases. More specifically, the present invention relates to certain imidazoquinazoline derivatives which have the general formula shown below wherein the substituents have the meanings defined in claim 1: and which have utility as platelet lowering agents in humans. The compounds of the present invention function by inhibiting megakaryocytopoeisis and hence the formation of blood platelets.
    Type: Application
    Filed: May 13, 2009
    Publication date: March 17, 2011
    Applicant: Shire LLC
    Inventors: Bernard Golding, Richard Franklin, Peter Cicala